Results 11 to 20 of about 32,649 (220)
Regulatory effects of protein S-acylation on insulin secretion and insulin action [PDF]
Open Biology, 2021 Post-translational modifications (PTMs) such as phosphorylation and ubiquitination are well-studied events with a recognized importance in all aspects of cellular function.
Luke H. Chamberlain +2 more
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Frontiers in Plant Science, 2022 Protein S-acylation, also known as palmitoylation, is an important lipid post-translational modification of proteins in eukaryotes. S-acylation plays critical roles in a variety of protein functions involved in plant development and responses to abiotic ...
Jincheng Li, Manqi Zhang, Lijuan Zhou
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Regulation of Dynamic Protein S-Acylation
Frontiers in Molecular Biosciences, 2021 Protein S-acylation is the reversible addition of fatty acids to the cysteine residues of target proteins. It regulates multiple aspects of protein function, including the localization to membranes, intracellular trafficking, protein interactions ...
Jessica J. Chen +2 more
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Acyl–Acyl Carrier Protein Desaturases and Plant Biotic Interactions [PDF]
Cells, 2021 Interactions between land plants and other organisms such as pathogens, pollinators, or symbionts usually involve a variety of specialized effectors participating in complex cross-talks between organisms. Fatty acids and their lipid derivatives play important roles in these biological interactions. While the transcriptional regulation of genes encoding
Sami Kazaz +2 more
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FASN inhibitor TVB-3166 prevents S-acylation of the spike protein of human coronaviruses
Journal of Lipid Research, 2022 The spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and other coronaviruses mediates host cell entry and is S-acylated on multiple phylogenetically conserved cysteine residues.
Katrina Mekhail +13 more
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Regulation of T cell function by protein S-acylation
Frontiers in Physiology, 2022 S-acylation, the reversible lipidation of free cysteine residues with long-chain fatty acids, is a highly dynamic post-translational protein modification that has recently emerged as an important regulator of the T cell function. The reversible nature of
Savannah J. West +4 more
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Regulation of ERK2 activity by dynamic S-acylation
Cell Reports, 2023 Summary: Extracellular signal-regulated kinases (ERK1/2) are key effector proteins of the mitogen-activated protein kinase pathway, choreographing essential processes of cellular physiology.
Saara-Anne Azizi +3 more
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Pathways of Non-enzymatic Lysine Acylation
Frontiers in Cell and Developmental Biology, 2021 Posttranslational protein modification by lysine acylation is an emerging mechanism of cellular regulation and fine-tunes metabolic processes to environmental changes.
Tim Baldensperger, Marcus A. Glomb
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Lysine Fatty Acylation: Regulatory Enzymes, Research Tools, and Biological Function
Frontiers in Cell and Developmental Biology, 2021 Post-translational acylation of lysine side chains is a common mechanism of protein regulation. Modification by long-chain fatty acyl groups is an understudied form of lysine acylation that has gained increasing attention recently due to the ...
Garrison Komaniecki +4 more
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S-acylation of P2K1 mediates extracellular ATP-induced immune signaling in Arabidopsis
Nature Communications, 2021 S-acylation is a reversible protein post-translational modification that often regulates protein function at the plasma membrane. Here the authors show that an Arabidopsis extracellular ATP receptor P2K1 mediates phosphorylation of two S-acyltransferases
Dongqin Chen +5 more
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