Results 91 to 100 of about 5,116,336 (302)

Protein homeostasis imprinting across evolution. [PDF]

NAR Genom Bioinform, 2020
Abstract Protein homeostasis (a.k.a. proteostasis) is associated with the primary functions of life, and therefore with evolution. However, it is unclear how cellular proteostasis machines have evolved to adjust protein biogenesis needs to environmental constraints. Herein, we describe a novel computational approach, based on semantic
Koutsandreas T, Felden B, Chevet E, Chatziioannou A.   +3 more
europepmc   +4 more sources

The role of 11β-hydroxysteroid dehydrogenase type 1 in bile acid homeostasis [PDF]

, 2013
Bile acids (BAs) are important modulators of metabolic functions such as lipid, triglyceride and glucose homeostasis. Intrahepatic accumulation of BAs is known to cause liver injury in cholestatic conditions, where normal trans-hepatic BA flow is ...
Penno, Carlos Alberto
core   +1 more source

Risk homeostasis theory - A study of intrinsic compensation [PDF]

, 1996
Risk homeostasis theory (RHT) suggests that changes made to the intrinsic risk of environments are negated in one of three ways: behavioural adjustments within the environment, mode migration, and avoidance of the physical risk.
Hoyes, TW, Stanton, Neville A., Taylor, R.G., Stanton, NA, Taylor, RG, Hoyes, Thomas W.   +5 more
core   +1 more source

Hepatocyte-specific deletion of peroxisomal protein PEX13 results in disrupted iron homeostasis

, 2020
Peroxisomes are organelles, abundant in the liver, involved in a variety of cellular functions, including fatty acid metabolism, plasmalogen synthesis and metabolism of reactive oxygen species.
Secondes, Eriza S., Subramaniam, V. Nathan, Melino, Michelle, Crane, Denis, Subramaniam, V Nathan, Secondes, Eriza S, Bhatia, Maneet, Rishi, Gautam   +7 more
core   +1 more source

Arabidopsis thaliana Nudix hydrolase AtNUDT7 forms complexes with the regulatory RACK1A protein and Ggamma subunits of the signal transducing heterotrimeric G protein. [PDF]

, 2011
Arabidopsis thaliana AtNUDT7 Nudix pyrophosphatase hydrolyzes NADH and ADP-ribose in vitro and is an important factor in the cellular response to diverse biotic and abiotic stresses.
Olejnik, Kamil, Kujawa, Martyna, Modzelan, Marta, Anielska-Mazur, Anna, Kraszewska, Elzbieta, Lipko, Agata, Bucholc, Maria, Augustyn, Agnieszka   +7 more
core   +2 more sources

Protein-RNA interactions: a structural analysis [PDF]

, 2001
A detailed computational analysis of 32 protein-RNA complexes is presented. A number of physical and chemical properties of the intermolecular interfaces are calculated and compared with those observed in protein-double-stranded DNA and protein-single ...
Daley, DT, Berman, HM, Luscombe, NM, Helen M Berman (10123868), Susan Jones (4079), Thornton, JM, David T A Daley (16115222), Janet M Thornton (16060073), Jones, S, Nicholas M Luscombe (8114756)   +9 more
core  

Proteostasis disruption under hypoxia: therapeutic targets in cancer and neurodegenerative diseases

Acta Biochimica Indonesiana
Proteostasis, the integrated network regulating protein synthesis, folding, trafficking, and degradation, is essential for cellular function and organismal health.
Susi Rahmiyati, Ani Retno Prijanti, Sri Widia A Jusman, Syarifah Dewi   +3 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Editorial: Protein posttranslational modifications in plant responses to abiotic stress - Women in plant science series

Frontiers in Plant Science, 2022
Agnieszka Sirko, Cecilia Gotor, Anna Wawrzyńska   +2 more
doaj   +1 more source

Integrated Time-Series Biochemical, Transcriptomic and Metabolomic Analyses Reveal Key Pathways and Concentration-Dependent Transitions in Chironomid Larvae (Propsilocerus akamusi) Under Chlorantraniliprole Stress

Animals
Chironomids are abundant aquatic macroinvertebrates with known pollutant tolerance, but the molecular effects of chlorantraniliprole (CAP) remain unclear. In this study, we exposed Propsilocerus akamusi larvae to LC10 and LC50 of CAP, sampled at 48 h and
Jiani Li, Wei Chen, Jian Mao, Runze Li, Chuncai Yan, Zeyang Sun   +5 more
doaj   +1 more source