Results 81 to 90 of about 1,466,359 (163)

Unraveling proteomic chaos by independent component analysis—ClpX proficiency promotes the iron and oxygen limitation responses of Staphylococcus aureus and affects the intracellular bacterial behavior

mSystems
In the opportunistic pathogen Staphylococcus aureus, protein homeostasis is largely mediated by the caseinolytic protease (Clp) system. The proteases ClpXP and ClpCP are crucial for general and targeted proteolysis, which rely on the unfoldases ClpX and ...
Larissa M. Busch, Hannes Wolfgramm, Supradipta De, Christian Hentschker, Manuela Gesell Salazar, Meike Kröber, Celina Hopp, Marie-Sofie Illenseher, Alexander Ganske, Stephan Michalik, Alexander Reder, Sven Hammerschmidt, Dorte Frees, Ulf Gerth, Kristin Surmann, Ulrike Mäder, Uwe Völker   +16 more
doaj   +1 more source

The role of ubiquitination in health and disease

MedComm
Ubiquitination is an enzymatic process characterized by the covalent attachment of ubiquitin to target proteins, thereby modulating their degradation, transportation, and signal transduction.
Yan Liao, Wangzheqi Zhang, Yang Liu, Chenglong Zhu, Zui Zou   +4 more
doaj   +1 more source

Putative Roles and Therapeutic Potential of the Chaperone System in Amyotrophic Lateral Sclerosis and Multiple Sclerosis

Cells
The putative pathogenic roles and therapeutic potential of the chaperone system (CS) in amyotrophic lateral sclerosis (ALS) and multiple sclerosis (MS) are reviewed to provide a bibliographic and conceptual platform for launching research on the ...
Leila Noori, Vahid Saqagandomabadi, Valentina Di Felice, Sabrina David, Celeste Caruso Bavisotto, Fabio Bucchieri, Francesco Cappello, Everly Conway de Macario, Alberto J. L. Macario, Federica Scalia   +9 more
doaj   +1 more source

Loss of popdc3 Impairs Mitochondrial Function and Causes Skeletal Muscle Atrophy and Reduced Swimming Ability in Zebrafish

Journal of Cachexia, Sarcopenia and Muscle
Background The Popeye domain containing 3 (POPDC3) protein is essential for the maintenance of skeletal muscle homeostasis. POPDC3 is a pathogenic variant gene of limb‐girdle muscular dystrophy (LGMD), and its variants lead to LGMDR26.
Chen‐Chen Sun, Zhang‐Lin Chen, Dong Yang, Jiang‐Ling Xiao, Xiang‐Tao Chen, Xi‐Yang Peng, Xiu‐Shan Wu, Chang‐Fa Tang   +7 more
doaj   +1 more source

Phenylhydrazone-based endoplasmic reticulum proteostasis regulator compounds with enhanced biological activity

eLife
Pharmacological enhancement of endoplasmic reticulum (ER) proteostasis is an attractive strategy to mitigate pathology linked to etiologically diverse protein misfolding diseases.
Gabriel M Kline, Lisa Boinon, Adrian Guerrero, Sergei Kutseikin, Gabrielle Cruz, Marnie P Williams, Ryan J Paxman, William E Balch, Jeffery W Kelly, Tingwei Mu, R Luke Wiseman   +10 more
doaj   +1 more source

Rescuing protein homeostasis [PDF]

Nature Reviews Drug Discovery, 2012
openaire   +1 more source

Disrupting protein homeostasis [PDF]

Nature Reviews Drug Discovery, 2015
openaire   +1 more source

Exploring the origins of neurodevelopmental proteasomopathies associated with cardiac malformations: are neural crest cells central to certain pathological mechanisms?

Frontiers in Cell and Developmental Biology
Neurodevelopmental proteasomopathies constitute a recently defined class of rare Mendelian disorders, arising from genomic alterations in proteasome-related genes.
Virginie Vignard, Alban-Elouen Baruteau, Alban-Elouen Baruteau, Alban-Elouen Baruteau, Bérénice Toutain, Sandra Mercier, Sandra Mercier, Bertrand Isidor, Bertrand Isidor, Richard Redon, Jean-Jacques Schott, Sébastien Küry, Sébastien Küry, Stéphane Bézieau, Stéphane Bézieau, Anne H. Monsoro-Burq, Anne H. Monsoro-Burq, Anne H. Monsoro-Burq, Frédéric Ebstein   +18 more
doaj   +1 more source

Structural Variations of Prions and Prion-like Proteins Associated with Neurodegeneration

Current Issues in Molecular Biology
Neurodegeneration is becoming one of the leading causes of death worldwide as the population expands and grows older. There is a growing desire to understand the mechanisms behind prion proteins as well as the prion-like proteins that make up ...
Carter Sky Christensen, Sean Wang, Wenshu Li, Danyang Yu, Henry James Li   +4 more
doaj   +1 more source

Editorial: Protein homeostasis in host-pathogen interactions

Frontiers in Microbiology, 2023
Jinki Yeom, Jinki Yeom, Jinki Yeom, Donghyuk Shin, Yuan Qiao, Yuan Qiao   +5 more
doaj   +1 more source