Results 1 to 10 of about 242,407 (95)
Characteristics of Human OAS1 Isoform Proteins [PDF]
Viruses, 2020 The human OAS1 (hOAS1) gene produces multiple possible isoforms due to alternative splicing events and sequence variation among individuals, some of which affect splicing. The unique C-terminal sequences of the hOAS1 isoforms could differentially affect synthetase activity, protein stability, protein partner interactions and/or cellular localization ...
Han Di +3 more
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The Isoforms of the p53 Protein [PDF]
Cold Spring Harbor Perspectives in Biology, 2009 p53 is a transcription factor with a key role in the maintenance of genetic stability and therefore preventing cancer formation. It belongs to a family of genes composed of p53, p63, and p73. The p63 and p73 genes have a dual gene structure with an internal promoter in intron-3 and together with alternative splicing, can express 6 and 29 mRNA variants,
Khoury, Marie P. +1 more
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Isoforms of the class II transactivator protein [PDF]
International Immunology, 2002 The class II transactivator (CIITA) controls both the constitutive and IFN-gamma inducible expression of HLA-D genes. In addition, through the squelching of another transactivator CREB-binding protein, CIITA was more recently shown to have a wider cellular function, including cell cycle control or cellular response to IFN-gamma and IL-4.
Barbieri G +10 more
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Isoform Divergence of the Filamin Family of Proteins [PDF]
Molecular Biology and Evolution, 2009 The vertebrate filamin family (A, B, and C) is part of the spectrin family of actin cross-linking proteins. Family members share high sequence similarity (>64%) and have both common and isoform-distinct functionalities. To identify the basis for isoform-specific functionality, we perform an evolutionary trace of chordate filamin at the granularity of ...
Barry Kesner +3 more
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Abundance and localization of human UBE3A protein isoforms [PDF]
Human Molecular Genetics, 2020 AbstractLoss ofUBE3A expression,a gene regulated by genomic imprinting, causes Angelman Syndrome (AS), a rare neurodevelopmental disorder. TheUBE3Agene encodes an E3 ubiquitin ligase with three known protein isoforms in humans. Studies in mouse suggest that the human isoforms may have differences in localization and neuronal function.
Carissa L. Sirois +8 more
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Heterogeneity of presynaptic proteins: do not forget isoforms [PDF]
Frontiers in Cellular Neuroscience, 2013 Analysis of presynaptic protein expression in glutamatergic and GABAergic central synapses performed in several laboratories and with different techniques is unveiling a complex scenario, largely because each presynaptic protein exists in several isoforms.
Luca eBragina +10 more
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Retinitis Pigmentosa GTPase Regulator (RPGR) protein isoforms in mammalian retina:insights into X-linked Retinitis Pigmentosa and associated ciliopathies [PDF]
, 2008 Mutations in the cilia-centrosomal protein Retinitis Pigmentosa GTPase Regulator (RPGR) are a frequent cause of retinal degeneration. The RPGR gene undergoes complex alternative splicing and encodes multiple protein isoforms. To elucidate the function of
Akimoto +80 more
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IsoSVM – Distinguishing isoforms and paralogs on the protein level [PDF]
BMC Bioinformatics, 2006 AbstractBackgroundRecent progress in cDNA and EST sequencing is yielding a deluge of sequence data. Like database search results and proteome databases, this data gives rise to inferred protein sequences without ready access to the underlying genomic data. Analysis of this information (e.g.
Spitzer, M +4 more
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Prediction of regulatory targets of alternative isoforms of the epidermal growth factor receptor in a glioblastoma cell line. [PDF]
, 2019 BackgroundThe epidermal growth factor receptor (EGFR) is a major regulator of proliferation in tumor cells. Elevated expression levels of EGFR are associated with prognosis and clinical outcomes of patients in a variety of tumor types. There are at least
Ardell, David H +7 more
core +3 more sources
The FU gene and its possible protein isoforms [PDF]
BMC Genomics, 2004 Abstract Background FU is the human homologue of the Drosophila gene fused whose product fused is a positive regulator of the transcription factor Cubitus interruptus (Ci). Thus, FU may act as a regulator of the human counterparts of Ci, the GLI transcription factors.
Charles E. Schwartz +9 more
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