Brain clusterin protein isoforms and mitochondrial localization [PDF]
eLife, 2019 Clusterin (CLU), or apolipoprotein J (ApoJ), is the third most predominant genetic risk factor associated with late-onset Alzheimer’s disease (LOAD). In this study, we use multiple rodent and human brain tissue and neural cell models to demonstrate that ...
Sarah K Herring +4 more
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Expression of p53 protein isoforms predicts survival in patients with multiple myeloma. [PDF]
Am J Hematol, 2022 Loss and/or mutation of the TP53 gene are associated with short survival in multiple myeloma, but the p53 landscape goes far beyond. At least 12 p53 protein isoforms have been identified as a result of a combination of alternative splicing, alternative ...
Rojas EA +16 more
europepmc +4 more sources
DeepLPI: a multimodal deep learning method for predicting the interactions between lncRNAs and protein isoforms [PDF]
BMC Bioinformatics, 2021 Background Long non-coding RNAs (lncRNAs) regulate diverse biological processes via interactions with proteins. Since the experimental methods to identify these interactions are expensive and time-consuming, many computational methods have been proposed.
Dipan Shaw +3 more
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RNA Biology, 2022 Endothelial cells (ECs) comprise the lumenal lining of all blood vessels and are critical for the functioning of the cardiovascular system. Their phenotypes can be modulated by alternative splicing of RNA to produce distinct protein isoforms.
Madison M. Mehlferber +9 more
doaj +2 more sources
Exploring the functional impact of alternative splicing on human protein isoforms using available annotation sources [PDF]
Briefings Bioinform., 2018 In recent years, the emphasis of scientific inquiry has shifted from whole-genome analyses to an understanding of cellular responses specific to tissue, developmental stage or environmental conditions.
Dinanath Sulakhe +9 more
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Abundance and localization of human UBE3A protein isoforms. [PDF]
Hum Mol Genet, 2020 Loss of UBE3A expression, a gene regulated by genomic imprinting, causes Angelman Syndrome (AS), a rare neurodevelopmental disorder. The UBE3A gene encodes an E3 ubiquitin ligase with three known protein isoforms in humans.
Sirois CL +7 more
europepmc +2 more sources
Induced alternative splicing an opportunity to study PCSK9 protein isoforms at physiologically relevant concentrations [PDF]
Scientific Reports, 2023 Splice modulating antisense oligomers (AOs) are increasingly used to modulate RNA processing. While most are investigated for their use as therapeutics, AOs can also be used for basic research.
Jessica M. Cale +6 more
doaj +2 more sources
Full-length transcriptome reconstruction reveals a large diversity of RNA and protein isoforms in rat hippocampus [PDF]
Nature Communications, 2019 Gene annotation is a critical resource in genomics research. Many computational approaches have been developed to assemble transcriptomes based on high-throughput short-read sequencing, however, only with limited accuracy.
Xi Wang +15 more
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IsoSVM – Distinguishing isoforms and paralogs on the protein level [PDF]
BMC Bioinformatics, 2006 Background Recent progress in cDNA and EST sequencing is yielding a deluge of sequence data. Like database search results and proteome databases, this data gives rise to inferred protein sequences without ready access to the underlying genomic data ...
Sczyrba Alexander +4 more
doaj +2 more sources
Netrin Family: Role for Protein Isoforms in Cancer. [PDF]
J Nucleic Acids, 2019 Netrins form a family of secreted and membrane-associated proteins. Netrins are involved in processes for axonal guidance, morphogenesis, and angiogenesis by regulating cell migration and survival. These processes are of special interest in tumor biology.
Bruikman CS +3 more
europepmc +2 more sources