Modular proteins from the Drosophila sallimus (sls) gene and their expression in muscles with different extensibility [PDF]
, 2007 The passive elasticity of the sarcomere in striated muscle is determined by large modular proteins, such as titin in vertebrates. In insects, the function of titin is divided between two shorter proteins, projectin and sallimus (Sls), which are the ...
Ayme-Southgate +53 more
core +1 more source
Plasma membrane association by N-acylation governs PKG function in Toxoplasma gondii [PDF]
, 2017 Cyclic GMP (cGMP)-dependent protein kinase (protein kinase G [PKG]) is essential for microneme secretion, motility, invasion, and egress in apicomplexan parasites, However, the separate roles of two isoforms of the kinase that are expressed by some ...
Brown, Kevin M +2 more
core +2 more sources
Large-scale analysis of human alternative protein isoforms: pattern classification and correlation with subcellular localization signals [PDF]
, 2005 We investigated human alternative protein isoforms of >2600 genes based on full-length cDNA clones and SwissProt. We classified the isoforms and examined their co-occurrence for each gene.
Barrero, R.A. +5 more
core +3 more sources
Netrin Family: Role for Protein Isoforms in Cancer [PDF]
Journal of Nucleic Acids, 2019 Netrins form a family of secreted and membrane-associated proteins. Netrins are involved in processes for axonal guidance, morphogenesis, and angiogenesis by regulating cell migration and survival. These processes are of special interest in tumor biology. From the netrin genes various isoforms are translated and regulated by alternative splicing.
Caroline Suzanne Bruikman +3 more
openaire +4 more sources
Crosstalk between G-protein and Ca2+ pathways switches intracellular cAMP levels [PDF]
, 2001 Cyclic adenosine monophosphate and cyclic guanosine monophosphate are universal intracellular messengers whose concentrations are regulated by molecular networks comprised of different isoforms of the synthases adenylate cyclase or guanylate cyclase and ...
A Dietz +22 more
core +2 more sources
In vivo imaging of the tonoplast intrinsic protein family in Arabidopsis roots [PDF]
, 2009 Background: Tonoplast intrinsic proteins (TIPs) are widely used as markers for vacuolar compartments in higher plants. Ten TIP isoforms are encoded by the Arabidopsis genome.
Frigerio, Lorenzo +4 more
core +4 more sources
Expression of connexins in human preimplantation embryos in vitro [PDF]
, 2004 Intercellular communication via gap junctions is required to coordinate developmental processes in the mammalian embryo. We have investigated if the connexin (Cx) isoforms known to form gap junctions in rodent preimplantation embryos are also expressed ...
Bloor, D.J. +6 more
core +4 more sources
Nuclear protein kinase C isoforms and apoptosis
European Journal of Histochemistry, 2009 The process of apoptosis is regulated at multiple levels through phosphorylation by several different protein kinases. The protein kinase C (PKC) family of isozymes have been shown to exert both inhibitory and stimulatory influences on apoptosis. During the apoptotic process phosphorylative events are known to occur also at the nuclear level.
MARTELLI, ALBERTO MARIA +2 more
openaire +9 more sources
Specific isoforms of translation initiation factor 4GI show differences in translational activity [PDF]
, 2006 The eukaryotic initiation factor (eIF) 4GI gene locus (eIF4GI) contains three identified promoters, generating alternately spliced mRNAs, yielding a total of five eIF4GI protein isoforms.
Coldwell, Mark J, Morley, Simon J
core +2 more sources
Backbone chemical shift assignments of human 14-3-3$\sigma$ [PDF]
, 2019 14-3-3 proteins are a group of seven dimeric adapter proteins that exert their biological function by interacting with hundreds of phosphorylated proteins, thus influencing their sub-cellular localization, activity or stability in the cell.
Boll, Emmanuelle +5 more
core +3 more sources