The Isoforms of the p53 Protein [PDF]
Cold Spring Harbor Perspectives in Biology, 2009 p53 is a transcription factor with a key role in the maintenance of genetic stability and therefore preventing cancer formation. It belongs to a family of genes composed of p53, p63, and p73. The p63 and p73 genes have a dual gene structure with an internal promoter in intron-3 and together with alternative splicing, can express 6 and 29 mRNA variants,
Khoury, Marie P. +1 more
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Frontiers in Microbiology, 2023 The largest family of transmembrane receptors are G-protein-coupled receptors (GPCRs). These receptors respond to perceived environmental signals and infect their host plants. Family A of the GPCR includes opsin.
Marzieh Mohri +3 more
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Global detection of human variants and isoforms by deep proteome sequencing
Nature Biotechnology, 2023 Deep proteome sequencing achieves ~80% coverage of the human proteome. An average shotgun proteomics experiment detects approximately 10,000 human proteins from a single sample.
Pavel Sinitcyn +11 more
semanticscholar +1 more source
Crosstalk between G-protein and Ca2+ pathways switches intracellular cAMP levels [PDF]
, 2001 Cyclic adenosine monophosphate and cyclic guanosine monophosphate are universal intracellular messengers whose concentrations are regulated by molecular networks comprised of different isoforms of the synthases adenylate cyclase or guanylate cyclase and ...
A Dietz +22 more
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Isoforms of the class II transactivator protein [PDF]
International Immunology, 2002 The class II transactivator (CIITA) controls both the constitutive and IFN-gamma inducible expression of HLA-D genes. In addition, through the squelching of another transactivator CREB-binding protein, CIITA was more recently shown to have a wider cellular function, including cell cycle control or cellular response to IFN-gamma and IL-4.
Barbieri G +10 more
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Enhanced protein isoform characterization through long-read proteogenomics
Genome Biology, 2022 Background The detection of physiologically relevant protein isoforms encoded by the human genome is critical to biomedicine. Mass spectrometry (MS)-based proteomics is the preeminent method for protein detection, but isoform-resolved proteomic analysis ...
Rachel M. Miller +15 more
doaj +1 more source
Tau Protein Hyperphosphorylation and Aggregation in Alzheimer’s Disease and Other Tauopathies, and Possible Neuroprotective Strategies [PDF]
, 2016 Acknowledgments This work was supported by The Croatian Science Foundation grant No. IP-2014-09-9730 (“Tau protein hyperphosphorylation, aggregation, and trans-synaptic transfer in Alzheimer’s disease: cerebrospinal fluid analysis and assessment of ...
Babić Leko, Mirjana +11 more
core +5 more sources
Identification and functional comparison of novel alternatively spliced isoforms of human YAP
FEBS Open Bio, 2023 As a key effector of the Hippo pathway, yes‐associated protein (YAP) is a major regulator of cell proliferation and apoptosis. In this study, 23 hYAP isoforms were identified in HEK293 cells, with 14 isoforms being reported for the first time.
Lianlian Liu +17 more
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Plasma membrane association by N-acylation governs PKG function in Toxoplasma gondii [PDF]
, 2017 Cyclic GMP (cGMP)-dependent protein kinase (protein kinase G [PKG]) is essential for microneme secretion, motility, invasion, and egress in apicomplexan parasites, However, the separate roles of two isoforms of the kinase that are expressed by some ...
Brown, Kevin M +2 more
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Functional diversity of human basic helix-loop-helix transcription factor TCF4 isoforms generated by alternative 5' exon usage and splicing. [PDF]
PLoS ONE, 2011 BackgroundTranscription factor 4 (TCF4 alias ITF2, E2-2, ME2 or SEF2) is a ubiquitous class A basic helix-loop-helix protein that binds to E-box DNA sequences (CANNTG).
Mari Sepp +4 more
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