Results 121 to 130 of about 4,093 (168)

Dysregulation of Different Modes of Programmed Cell Death in Rheumatoid Arthritis Fibroblast-Like Synoviocyte. [PDF]

Int J Rheum Dis
Zhi X, Zhu H, Sun X, Wang Z, Wang L, Song G.   +5 more
europepmc   +1 more source

Innovative cross-intervention: copper ions and metabolic pathways in cancer therapy. [PDF]

Cancer Biol Med
Niu L, Su W, Ju L, Xiang J, Yang Z, Yao B.   +5 more
europepmc   +1 more source

ZFT is the major iron and zinc transporter in <i>Toxoplasma gondii</i>. [PDF]

Elife
Aghabi D, Gallego Rubio C, Cortijo Martinez M, Pouzache A, Gibson EJ, Pagura L, Fairweather SJ, van Dooren GG, Harding CR.   +8 more
europepmc   +1 more source

Cuproptosis as a Potential Therapeutic Target for Steatotic Liver Disease. [PDF]

Biomolecules
Pan Y, Luo C, Guo Q, Duan Q, Wu Z, Li Y.
europepmc   +1 more source

Copper, Cuproptosis, and Neurodegenerative Diseases. [PDF]

Int J Mol Sci
Genchi G, Catalano A, Carocci A, Sinicropi MS, Lauria G.   +4 more
europepmc   +1 more source

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Quantitative Site-Specific Chemoproteomic Profiling of Protein Lipoylation

Journal of the American Chemical Society, 2022
Protein lipoylation is an evolutionarily conserved post-translational modification from prokaryotes to eukaryotes. Lipoylation is implicated with several human diseases, including metabolic disorders, cancer, and Alzheimer's disease. While individual lipoylated proteins have been biochemically studied, a strategy for globally quantifying lipoylation ...
Shuchang Lai, Ying Chen, Fan Yang, Weidi Xiao, Yuan Liu, Chu Wang   +5 more
openaire   +2 more sources

Chemical Tagging of Protein Lipoylation

Angewandte Chemie, 2020
AbstractProtein lipoylation is a post‐translational modification of emerging importance in both prokaryotes and eukaryotes. However, labeling and large‐scale profiling of protein lipoylation remain challenging. Here, we report the development of iLCL (iodoacetamide‐assisted lipoate‐cyclooctyne ligation), a chemoselective reaction that enables chemical ...
Qi Tang, Yilan Guo, Liying Meng, Xing Chen   +3 more
openaire   +2 more sources

Copper induces cell death by targeting lipoylated TCA cycle proteins

Science, 2022
Copper is an essential cofactor for all organisms, and yet it becomes toxic if concentrations exceed a threshold maintained by evolutionarily conserved homeostatic mechanisms. How excess copper induces cell death, however, is unknown. Here, we show in human cells that copper-dependent, regulated cell death is distinct from known death mechanisms and is
Peter Tsvetkov, Shannon Coy, Boryana Petrova, Margaret Dreishpoon, Ana Verma, Mai Abdusamad, Jordan Rossen, Lena Joesch-Cohen, Ranad Humeidi, Ryan D. Spangler, John K. Eaton, Evgeni Frenkel, Mustafa Kocak, Steven M. Corsello, Svetlana Lutsenko, Naama Kanarek, Sandro Santagata, Todd R. Golub   +17 more
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Two redundant octanoyltransferases and one obligatory lipoyl synthase provide protein‐lipoylation autonomy to plastids of Arabidopsis

Plant Biology, 2013
AbstractOctanoyltransferases (LIP2) are important for the lipoylation of several α‐ketoacid decarboxylases and glycine decarboxylase, all of which are essential multienzyme complexes of central metabolism, by attaching de novo‐synthesised octanoyl moieties to the respective target subunits.
R, Ewald, C, Hoffmann, E, Neuhaus, H, Bauwe   +3 more
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Lipoylated Peptides and Proteins

2015
Lipoic acid is a heterocyclic sulfur-containing derivative of octanoic acid that is characterized by a 1,2-dithiolane ring. Found in nature as an essential protein cofactor, lipoic acid is implicated in cellular metabolic reactions. In particular, lipoylation is an essential posttranslational modification involved in cellular energetic metabolism ...
Rentier, Cédric, Pacini, Giulia, NUTI, FRANCESCA, ROVERO, PAOLO, PAPINI, ANNA MARIA   +4 more
openaire   +1 more source