Results 101 to 110 of about 3,788 (176)

ASPP2 inhibits hepatocellular carcinoma growth by regulating cuproptosis via mitochondrial protein lipoylation

Cell Death & Disease
Abstract Hepatocellular carcinoma (HCC) is a metabolically active malignancy. Cuproptosis, a copper-dependent programmed cell death pathway, has been found to be closely associated with tumor progression. Cells with strong oxidative phosphorylation (OXPHOS) capacity exhibit heightened susceptibility to cuproptosis. We demonstrate that
Lu Yang, Xuhui Li, Yutong Jiang, Mingzhu Zhang, Tiantian Wu, Peixian Pi, Zhuozhuo Han, Zhiyu Zhang, Fangyuan Kong, Xiuhong Lu, Hao Yang, Chaohui Zuo, Gang Huang, Jian Zhao, Beibei Liang   +14 more
openaire   +1 more source

When copper turns killer: Decoding copper dyshomeostasis and cuproptosis in neurodegenerative pathogenesis and precision metal interventions

Neural Regeneration Research
Copper is an essential cofactor for neuronal metabolism, enzymatic functions, and neurotransmission. However, copper dyshomeostasis-induced redox activity makes the brain vulnerable to oxidative and proteostatic stress.
Wei Du, Tingyao Wu, Yonggang Fan, Min Zhao   +3 more
doaj   +1 more source

Cuproptosis: lipoylated TCA cycle proteins-mediated novel cell death pathway

Signal Transduction and Targeted Therapy, 2022
Su-Ran Li, Lin-Lin Bu, Lulu Cai
openaire   +3 more sources

Redox Network Dysfunction: Integrating Ferroptosis and Cuproptosis Across Human Diseases

Antioxidants
Oxidative stress (OS) is increasingly recognized as a dynamic disturbance of cellular redox networks rather than a simple imbalance between oxidants and antioxidants. In this context, ferroptosis and cuproptosis—two regulated and metal-dependent forms of
Federica Li Pomi, Guglielmo Di Leo, Sara Genovese, Francesco Borgia, Sebastiano Gangemi   +4 more
doaj   +1 more source

p53 enhances elesclomol-Cu-induced cuproptosis in hepatocellular carcinoma via FDXR-mediated FDX1 upregulation

Frontiers in Oncology
BackgroundCuproptosis, a novel cell death pathway mediated by ferredoxin 1 (FDX1) and protein lipoylation, has emerged as a valuable target in cancer therapy.
Xiao Liu, Honglin Qu, Jingmin Li, Xuhong Sun, Zhenlin Wang, Dong Wang, Xianyong Bai, Xiaoyan Li   +7 more
doaj   +1 more source

Sirtuin-regulated lipoylation is an evolutionarily conserved mediator of metabolic health and disease

, 2018
Lipoylation is a rare, but highly conserved lysine posttranslational modification. To date, it is known to occur on only four multimeric metabolic enzymes in mammals, yet these proteins are staples in the core metabolic landscape.
Rowland, Elizabeth
core  

Cuproptosis in stroke: Molecular mechanisms and therapeutic targeting of copper-mediated cell death

Brain Research Bulletin
The recent identification of cuproptosis, a regulated cell death pathway dependent on copper, has reshaped our understanding of post-stroke neurodegeneration.
Pengpeng Li, Yangyang Gao, Wei Liu
doaj   +1 more source

Comprehensive analysis of cuproptosis-related genes in diabetic cardiomyopathy.

PLoS ONE
BackgroundDiabetic cardiomyopathy (DCM) represents a distinct myocardial pathology arising from chronic diabetic metabolic disturbances, characterized by progressive structural and functional abnormalities that frequently culminate in heart failure ...
Jun Li, Hua Zhang, Xinyue Duan, Meina Zhang, Xin Li, Chunyan Hao   +5 more
doaj   +1 more source

Identification of SLC31A1 as a prognostic biomarker and a target for therapeutics in breast cancer

Scientific Reports
Copper-induced cell death is regulated through protein lipoylation, which is critical for gene expression and phenotypic regulation. Neverless, the role of Cuproptosis-related genes in breast cancer (BC) remains unknown.
Hongtao Fu, Shanshan Dong, Kun Li
doaj   +1 more source

Characterization of tumor prognosis and sensitive chemotherapy drugs based on cuproptosis-related gene signature in ovarian cancer

BMC Women's Health
Background Cuproptosis is a novel form of cell death, acting on the tricarboxylic acid cycle in mitochondrial respiration and mediated by protein lipoylation.
Wei Tan, Fangfang Dai, Qinyu Ci, Zhimin Deng, Hua Liu, Yanxiang Cheng   +5 more
doaj   +1 more source