Results 101 to 110 of about 3,349,944 (177)

Growth and lipoylation of Lpa constructs containing only the amidase domain.

, 2013
(A) Growth assay of E. coli cells expressing Lpat471 (closed triangles) and Lpat521 (open squares) compared to expression of Lpa (open triangles) and vector alone (open circles).
Sean T. Prigge (370088), Maroya D. Spalding (370087)   +1 more
core   +1 more source

Identification of cuproptosis-related subtypes, construction of a prognosis model, and tumor microenvironment landscape in multiple myeloma

Translational Oncology
Multiple myeloma (MM) is a challenging hematologic malignancy with increasing incidence. Cuproptosis, a copper-dependent form of cell death associated with mitochondrial metabolism and protein lipoylation, remains unexplored in MM.
Li Xu, Hui Zhang, Kai Wang, Xuejie Gao, Wenxuan Bu, Dandan Yu, Ke Hu, Qikai Zhang, Guanli Wang, Xiaosong Wu, Xinyan Jia, Yu Peng, Dongliang Song, Hongfei Yi, Haiyan Cai, Jumei Shi, Qilin Feng   +16 more
doaj   +1 more source

Cloning, expression and lipoylation of the rabbit H-protein of the glycine cleavage system

, 2002
The H-protein is one of four essential subunits of the glycine cleavage system (GCS). The H-protein requires the addition of a lipoic acid prosthetic group for full biochemical activity, and with this prosthetic group the H-protein dunctions to shuttle ...
Sharp, Lisa Louise
core  

Research progress on the regulation of cuproptosis-related genes by non-coding RNAs in tumors

Oncologie
Cuproptosis represents a mechanistically distinct programmed cell death pathway divergent from canonical apoptosis, necrosis, and ferroptosis. This copper-dependent process critically modulates tumorigenesis, malignant progression, and clinical outcomes ...
Du Yuxin, Zhang Zhendong, Cao Mingyuan, Hou Xinrui, Wang Xiaoping   +4 more
doaj   +1 more source

Comparative genomic analysis of lipoylation pathways in archaea.

, 2014
The genomic presence of lipoylation enzymes LplA-N, LipM or LipB and their substrate OADHC E2 is indicated. Archaeal orders lacking lipoylation pathways are highlighted (grey shading). The broad metabolic environment of each archaeal order and the number
Abhishek Upadhyay (516068), Stefan Bagby (516070), Mareike G. Posner (516067), Michael J. Danson (516069), Steve Dorus (396113), Kirill Borziak (190779)   +5 more
core   +1 more source

Metabolic cell death networks in Alzheimer’s disease: mechanistic links and therapeutic perspectives of ferroptosis, cuproptosis, and disulfidptosis

Frontiers in Cell and Developmental Biology
Alzheimer’s disease (AD) is a neurodegenerative disorder characterized primarily by progressive cognitive impairment, whose pathogenesis involves multiple pathological processes including protein deposition, metal homeostasis dysregulation, oxidative ...
Shuyu Ding, Zihan Guo, Hengyu Ji, Jinting He   +3 more
doaj   +1 more source

Mitochondrial copper stabilizes lipoylated TCA cycle proteins to sustain metabolism and proliferation

Abstract Copper (Cu) is an essential cofactor for mitochondrial cytochrome c oxidase, yet whether it directly regulates mitochondrial metabolism beyond respiration remains unclear.
Santanu Ghosh, Andrew F. Jarvis, Jordi C.J. Hintzen, Nate R. McKnight, Pedro Costa-Pinheiro, Noelle H. Noughton, Yumi Kim, Alison Jaccard, Scot C. Leary, Paul A. Cobine, Caroline R. Bartman, Gina M. DeNicola, Nathaniel W. Snyder, Kathryn E. Wellen, George M. Burslem, Donita C. Brady   +15 more
openaire   +1 more source

Lipoylation and biotinylation sites.

, 2013
(A) Amino acid sequence alignments of lipoylation and biotinylation sites in E. coli. The lysine that is involved in lipoic acid or biotin attachment is marked in bold.
Sean T. Prigge (370088), Maroya D. Spalding (370087)   +1 more
core   +1 more source

Growth, lipoylation, and biotinylation of cells expressing Lpa and Lpa active site mutants.

, 2013
(A) Growth assay of E. coli BL21 cells expressing Lpa (open triangles) compared to vector alone (open circles) and the three active site mutants: Lpa K159A (open squares), Lpa S235A (closed circles), and Lpa S259A (closed triangles).
Sean T. Prigge (370088), Maroya D. Spalding (370087)   +1 more
core   +1 more source

Cuproptosis: lipoylated TCA cycle proteins-mediated novel cell death pathway

Signal Transduction and Targeted Therapy, 2022
Su-Ran Li, Lin-Lin Bu, Lulu Cai
openaire   +3 more sources