Results 81 to 90 of about 3,788 (176)

Diversity of FAAL enzymes and prediction of their substrate specificity using FAALPred

Protein Science, Volume 35, Issue 2, February 2026.
Abstract FAALs (fatty acyl‐AMP ligases) recruit and incorporate fatty acids during the biosynthesis of secondary metabolites. Their diversity, distribution, and substrate specificity remain poorly understood, which limits functional predictions from sequence data.
Anne Liong, Leandro de Mattos Pereira, Pedro N. Leão   +2 more
wiley   +1 more source

Growth and lipoylation of Lpa constructs containing only the amidase domain.

, 2013
(A) Growth assay of E. coli cells expressing Lpat471 (closed triangles) and Lpat521 (open squares) compared to expression of Lpa (open triangles) and vector alone (open circles).
Sean T. Prigge (370088), Maroya D. Spalding (370087)   +1 more
core   +1 more source

Plasmodium falciparum glutamate dehydrogenase a is dispensable and not a drug target during erythrocytic development [PDF]

, 2011
<p>Background: Plasmodium falciparum contains three genes encoding potential glutamate dehydrogenases. The protein encoded by gdha has previously been biochemically and structurally characterized.
Sylke Müller, Aparicio, I., Eva-Maria Patzewitz, Perner Jan, Isabela Aparicio, Patzewitz, E.-M., Llinas, M., Storm, J., Llinas Manuel, Engel Paul C, Olszewski Kellen, Janet Storm, Perner, J., Storm Janet, Paul C Engel, Kellen Olszewski, Engel, P.C., Manuel Llinas, Olszewski, K., Muller, S., Müller Sylke, Aparicio Isabela, Patzewitz Eva-Maria, Jan Perner   +23 more
core   +1 more source

Lipoylation and assembly of a 2-oxoacid dehydrogenase multienzyme complex from thermoplasma acidophilum [PDF]

, 2009
Energy generating processes like the citric acid cycle are a pivotal part of metabolism. Members of the 2-oxoacid dehydrogenase multienzyme complex (OADHC) superfamily feed into and act within the citric acid cycle.
Posner, Mareike
core  

A response to iron involving carbon metabolism in the opportunistic fungal pathogen Candida albicans

mSphere
Iron (Fe) is an essential micronutrient, and during infection, the host attempts to starve pathogens of this vital element through a process known as nutritional immunity.
Ritu Garg, Zhengkai Zhu, Francisco G. Hernandez, Yiran Wang, Marika S. David, Vincent M. Bruno, Valeria C. Culotta   +6 more
doaj   +1 more source

Growth, lipoylation, and biotinylation of cells expressing Lpa and Lpa active site mutants.

, 2013
(A) Growth assay of E. coli BL21 cells expressing Lpa (open triangles) compared to vector alone (open circles) and the three active site mutants: Lpa K159A (open squares), Lpa S235A (closed circles), and Lpa S259A (closed triangles).
Sean T. Prigge (370088), Maroya D. Spalding (370087)   +1 more
core   +1 more source

Protein-protein interactions within the 2-oxoacid dehydrogenase complexes [PDF]

, 1999
The 2-oxoacid dehydrogenase complexes; pyruvate dehydrogenase (PDC), 2- oxoglutarate dehydrogenase (OGDC) and branch-chain 2-oxoacid dehydrogenase (BCOADC), are mitochondrial multienzyme complexes which comprise of multiple copies of three different ...
Richards, Susan Diane
core   +1 more source

A globular protein exhibits rare phase behavior and forms chemically regulated orthogonal condensates in cells

Nature Communications
Proteins with chemically regulatable phase separation are of great interest in the fields of biomolecular condensates and synthetic biology. Intrinsically disordered proteins (IDPs) are the dominating building blocks of biomolecular condensates which ...
Jinglei Nie, Xinyi Zhang, Zhijuan Hu, Wei Wang, Martin A. Schroer, Jie Ren, Dmitri Svergun, Anyang Chen, Peiguo Yang, An-Ping Zeng   +9 more
doaj   +1 more source

Understanding the Dynamics of Protein Lipoylation in Staphylococcus Aureus

, 2018
Staphylococcus aureus is a commensal bacterium that also acts as an opportunistic pathogen. The pathogenicity of S. aureus has often been attributed to the wide range of virulence factors that the bacterium produces. While virulence factors do contribute
Flury, Sarah C
core  

Biallelic Mutations in LIPT2 Cause a Mitochondrial Lipoylation Defect Associated with Severe Neonatal Encephalopathy

, 2017
Item does not contain fulltextLipoate serves as a cofactor for the glycine cleavage system (GCS) and four 2-oxoacid dehydrogenases functioning in energy metabolism (alpha-oxoglutarate dehydrogenase [alpha-KGDHc] and pyruvate dehydrogenase [PDHc]), or ...
Laroche, Cécile, Chadefaux-Vekemans, Bernadette, Nicolas Goudin, Lebigot, E., Patrick Nitschke, Stefan Kölker, Ottolenghi, Chris, de Lonlay, P., Delahodde, Agnès, Rotig, Agnes, Pontoizeau, Clément, Nitschke, P., Goudin, N., Tobias B. Haack, Busiah, Kanetee, Haack, T.B., Audrey Boutron, Marquardt, Iris, Lebigot, Elise, Johannes A. Mayr, Delahodde, A., Eisermann, M., Prokisch, H., Boutron, Audrey, Chris Ottolenghi, Bole-Feysot, C., Chretien, D., Hamel, Yamina, Agnès Delahodde, Mayr, J.A., Nathalie Boddaert, Rodenburg, R.J., Yamina Hamel, René G. Feichtinger, Lonlay, Pascale,, Bole-Feysot, Christine, Cécile Laroche, Elise Lebigot, Madrange, M., Grisel, C., Rodenburg, R.J.T., Christine Bole-Feysot, Lonlay, P. de, Meitinger, T., Clément Pontoizeau, Marquardt, I., Coraline Grisel, Habarou, Florence, Laroche, C., Kölker, Stefan, Nemazanyy, I., Kolker, S., Nemazanyy, Ivan, Florence Habarou, Iris Marquardt, Mayr, Johannes A., Monika Eisermann, Eisermann, Monika, Agnes Rotig, Marine Madrange, Pascale de Lonlay, Tim M. Strom, Chrétien, Dominique, Boddaert, Nathalie, G. Christoph Korenke, Boddaert, N., Feichtinger, René G., Strom, T.M., Pontoizeau, C., Kanetee Busiah, Boutron, A., Busiah, K., Korenke, G.C., Haack, Tobias B., Barouki, Robert, Prokisch, Holger, Feichtinger, R.G., Goudin, Nicolas, Meitinger, Thomas, Dominique Chrétien, Richard J. Rodenburg, Strom, Tim M., Barouki, R., Lonlay, Pascale, De, Ottolenghi, C., Rotig, A., Ivan Nemazanyy, Bernadette Chadefaux-Vekemans, Thomas Meitinger, Korenke, G. Christoph, Madrange, Marine, Grisel, Coraline, Rodenburg, Richard J., Chadefaux-Vekemans, B., Nitschke, Patrick, Robert Barouki, Habarou, F., Hamel, Y., Holger Prokisch   +98 more
core   +1 more source