Results 71 to 80 of about 3,788 (176)

Epigenetic regulation of cuproptosis in cancer: mechanisms, microenvironment, and therapeutic implications

Frontiers in Cell and Developmental Biology
Cuproptosis is a regulated form of cell death triggered by copper overload and dependent on mitochondrial metabolism, particularly through FDX1-mediated protein lipoylation and TCA cycle disruption. Recent studies have revealed that epigenetic mechanisms,
Xin Zhang, Yixiao Yuan, Lin Tang, Juan Wang, Lincan Duan, Xiulin Jiang, Jia Zhang   +6 more
doaj   +1 more source

FOXC1‐ATP7A Axis Activates PI3K/AKT Signaling to Suppress Cuproptosis and Drive Fibroblast Pathogenesis in Rheumatoid Arthritis

The FASEB Journal, Volume 40, Issue 8, 30 April 2026.
This graphical abstract illustrates the regulatory mechanism of the FOXC1‐ATP7A axis in Rheumatoid Arthritis (RA). Bioinformatics analysis identifies FOXC1 as a hub transcription factor that is significantly upregulated in RA synovial tissues and fibroblast‐like synoviocytes (FLSs).
Daomin Lu, Fang Tang, Zong Jiang, Wukai Ma, Changming Chen, Lei Hou, Qianwei Lu, Xueming Yao, Danyang Li, Weiya Lan   +9 more
wiley   +1 more source

Mitochondrial Protein Lipoylation Does Not Exclusively Depend on the mtKAS Pathway of de Novo Fatty Acid Synthesis in Arabidopsis [PDF]

Plant Physiology, 2007
Abstract The photorespiratory Arabidopsis (Arabidopsis thaliana) mutant gld1 (now designated mtkas-1) is deficient in glycine decarboxylase (GDC) activity, but the exact nature of the genetic defect was not known. We have identified the mtkas-1 locus as gene At2g04540, which encodes β-ketoacyl-[acyl carrier protein (ACP)] synthase (mtKAS)
Ralph, Ewald, Uner, Kolukisaoglu, Ursula, Bauwe, Stefan, Mikkat, Hermann, Bauwe   +4 more
openaire   +2 more sources

Cuproptosis and prostate cancer: from molecular mechanisms and microenvironment remodeling to precision therapy

Frontiers in Oncology
Prostate cancer (PCa) is a leading malignancy, and progression to castration-resistant prostate cancer (CRPC) remains a central therapeutic challenge.
Zhonghao Tang, Zhonghao Tang, Si Shen, Si Shen, Chen Guo, Chen Guo, Anjie Chen, Anjie Chen, Dongjie Yang, Jian Sun, Yuanyuan Mi   +10 more
doaj   +1 more source

Asymmetric Cu─N─Ru Bridgedsite Nanozyme‐Loaded Injectable Thermogel Boosts Cuproptosis‐Like Death for Multidrug‐Resistant Urinary Tract Infections

Advanced Science, Volume 13, Issue 19, 2 April 2026.
To address multidrug‐resistant urinary tract infections (MDR‐UTIs), we developed Cu‐ZIF8‐Ru nanozyme featuring an asymmetric Cu─N─Ru catalytic site. This unique structure enhances multienzyme‐mimetic activity, eradicating resistant bacteria by inducing a cuproptosis‐like death pathway through intracellular Cu2+ accumulation and energy depletion.
Guanlin Li, Shike Zhang, Jinggong Liu, Xin Wang, Heng Wang, Hongcan Yang, Yuhao Zhou, Wen Liu, Hongxing Liu, Wenqi Wu   +9 more
wiley   +1 more source

Crystal structure of lipoate‐bound lipoate ligase 1, LipL1, from Plasmodium falciparum [PDF]

, 2017
Plasmodium falciparum lipoate protein ligase 1 (PfLipL1) is an ATP‐dependent ligase that belongs to the biotin/lipoate A/B protein ligase family (PFAM PF03099).
Prigge, Sean T., Gustavo A. Afanador, Alfredo J. Guerra, Sean T. Prigge, Guerra, Alfredo J., Afanador, Gustavo A.   +5 more
core   +1 more source

Investigating the Role of Metabolic Reprogramming in the Pathogenesis of Diabetic Kidney Disease Using Novel Metabolic Mouse Models

, 2023
Metabolic disorders are involved in the pathogenesis of diabetic kidney disease (DKD), and protein lipoylation may regulate metabolic disorders and energy reprogramming in DKD.
Wallace, E (via Mendeley Data)
core   +1 more source

PIK‐III‐Mediated Elevation of Thiamine Re‐Sensitises Renal Cell Carcinoma to Cuproptosis via Activating PDHA1

Cell Proliferation, Volume 59, Issue 3, March 2026.
PIK‐III enhancing the efficacy of cuproptosis to kill renal cancer cells through dysregulating thiamine metabolism and dephosphorylation of pyruvate dehydrogenase complex E1 (PDHA1), providing a potential option for treatment of cuproptosis‐resistant renal cancer by the combination of PIK‐III and elesclomol.
Dongdong Xie, Yu Wang, Wenjie Cheng, Minbo Yan, Kunyu Li, Xiang Wu, Jiaqing Wu, Zhuangzhuang Zhang, Yingbo Dai   +8 more
wiley   +1 more source

cDNA sequence, in vitro synthesis, and intramitochondrial lipoylation of H-protein of the glycine cleavage system.

Journal of Biological Chemistry, 1990
H-protein is a component of the glycine cleavage system loosely associated with the mitochondrial inner membrane and has lipoic acid as a prosthetic group. cDNA clones encoding H-protein were isolated from a bovine liver cDNA library with an oligonucleotide probe from the amino acid sequence of the NH2-terminal region. DNA sequence analysis and deduced
K, Fujiwara, K, Okamura-Ikeda, Y, Motokawa   +2 more
openaire   +2 more sources

NADH‐Reductive Stress Induced by Dihydrolipoamide Dehydrogenase Activation Contributes to Cuproptosis

Advanced Science, Volume 13, Issue 9, 13 February 2026.
This study demonstrates a cuproptosis mechanism involving nicotinamide adenine dinucleotide (NADH)‐reductive stress in neural cells. Copper activates dihydrolipoamide dehydrogenase under mitochondrial pH, accumulating NADH. Copper also induces mitochondrial permeability transition pore opening, facilitating NADH translocation to the cytosol and ...
Si‐Yi Zhang, Xing‐Hua Ren, Cheng‐Hong Zhang, Zhan‐You Wang   +3 more
wiley   +1 more source