Results 91 to 100 of about 3,788 (176)

Identification of cuproptosis-related subtypes, construction of a prognosis model, and tumor microenvironment landscape in multiple myeloma

Translational Oncology
Multiple myeloma (MM) is a challenging hematologic malignancy with increasing incidence. Cuproptosis, a copper-dependent form of cell death associated with mitochondrial metabolism and protein lipoylation, remains unexplored in MM.
Li Xu, Hui Zhang, Kai Wang, Xuejie Gao, Wenxuan Bu, Dandan Yu, Ke Hu, Qikai Zhang, Guanli Wang, Xiaosong Wu, Xinyan Jia, Yu Peng, Dongliang Song, Hongfei Yi, Haiyan Cai, Jumei Shi, Qilin Feng   +16 more
doaj   +1 more source

Cloning, expression and lipoylation of the rabbit H-protein of the glycine cleavage system

, 2002
The H-protein is one of four essential subunits of the glycine cleavage system (GCS). The H-protein requires the addition of a lipoic acid prosthetic group for full biochemical activity, and with this prosthetic group the H-protein dunctions to shuttle ...
Sharp, Lisa Louise
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Identification of a Class of Protein ADP-Ribosylating Sirtuins in Microbial Pathogens

, 2015
Sirtuins are an ancient family of NAD(+)-dependent deacylases connected with the regulation of fundamental cellular processes including metabolic homeostasis and genome integrity.
Matić, I., Leidecker, Orsolya, Traven, A, Qu, Yue, Qu, Y, Peleg, Anton Y, Kraehenbuehl, R., Qu, Y., Ariza, Antonio, Leidecker, O, Morra, R., Morra, Rosa, Rack, Johannes, Rack, Johannes G M, Peleg, A., Kraehenbuehl, R, Ahel, I., Rack, Johannes Gregor Matthias, Ahel, Ivan, Ortmayer, M, Peleg, Anton, Cameron, D.R., Traven, A., Leys, D., Leidecker, O., Cameron, DR, Ahel, I, Rack, J., Ariza, A, Cameron, David, Ariza, A., Morra, R, Cameron, D., Matic, I, Rack, JG, Leys, D, Rack, J.G.M., Peleg, A.Y., Barkauskaite, Eva, Barkauskaite, E., Kraehenbuehl, Rolf, Barkauskaite, E, Peleg, AY, Matic, Ivan, Traven, Ana, Leys, David, Ortmayer, M., Cameron, David R, Ortmayer, Mary   +48 more
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Research progress on the regulation of cuproptosis-related genes by non-coding RNAs in tumors

Oncologie
Cuproptosis represents a mechanistically distinct programmed cell death pathway divergent from canonical apoptosis, necrosis, and ferroptosis. This copper-dependent process critically modulates tumorigenesis, malignant progression, and clinical outcomes ...
Du Yuxin, Zhang Zhendong, Cao Mingyuan, Hou Xinrui, Wang Xiaoping   +4 more
doaj   +1 more source

Mutations in the lipoyltransferase LIPT1 gene cause a fatal disease associated with a specific lipoylation defect of the 2-ketoacid dehydrogenase complexes

, 2014
International audienceCofactor disorders of mitochondrial energy metabolism are a heterogeneous group of diseases with a wide variety of clinical symptoms, particular metabolic profiles and variable enzymatic defects.
Quintana, E., Thio, M., Arias, A., Garcia-Villoria, J., Tort, F., Garcia-Cazorla, A., Matalonga, L., Acquaviva, C., Bujan, N., Navarro-Sastre, A., Briones, P., Ribes, A., Artuch, R., Ferrer-Cortes, X., Vianey-Saban, Christine   +14 more
core   +1 more source

Analysis of lipoylation of Lat1p, Kgd2p and Gcv3p.

, 2014
(A) Regions I–III (framed in figure 3) from the 2D gels of wild type (WT) and Tet-Sat4 are shown. Arrowheads indicate spots that are discussed in the text. Spots marked with open arrows represent the respective lipoylated protein form.
Udo Krause (613750), Gerhard Rödel (326147), Cornelia Czupalla (613749), Bernard Hoflack (164600), Uta Gey (613748)   +4 more
core   +1 more source

Targeting SERPINB3–MAPK axis-mediated cuproptosis resistance enhances the response to antitumor immunotherapy

Molecular Cancer
Cuproptosis, a newly identified form of cell death, is closely linked to copper homeostasis and protein lipoylation. Using a multi-omics approach, we firstly reveal that SERPINB3 confers cuproptosis resistance in pancreatic cancer and functions as a ...
Xiao-Xiao Huang, Cheng-Ke Xie, Yi-Chao Mo, Wei Li, Yong-Ding Wu, Zhi-Yuan Li, Hao-Xiang Zhang, Ge Li, Long Jin, Xin-Quan Lin, Jian-Fei Hu, Yin-Hao Chen, Hong-Yi Lin, Shun-Cang Zhu, Jin-Peng Lu, Hou-Juan Zhu, Wan-Wan Wang, Yi Huang, Zu-Wei Wang, Long Huang, Dan-Feng Wang, Yi-Feng Tian, Cheng-Yu Liao, Shi Chen   +23 more
doaj   +1 more source

A novel role of tRNA-derived fragments in porcine granulosa-oocyte cell communication and cuproptosis.

PLoS Genetics
Copper is essential for reproductive function, yet its accumulation can lead to cytotoxicity and cuproptosis. However, the specific molecular mechanisms underlying granulosa cell cuproptosis and follicular atresia remain unclear.
Linyuan Shen, Xue Zhao, Shuang Wu, Yuhang Lei, Shuang Liang, Saihao Wang, Haodong Dai, Yan Wang, Lei Chen, Ye Zhao, Mailin Gan, Shijun Xiao, Guangbin Zhou, Li Zhu   +13 more
doaj   +1 more source

GCS-H2 is essential for growth as it acts as the main relay for mitochondrial lipoylation in heterotrophic tissues of Arabidopsis thaliana

International audienceH-protein is part of the multi-protein glycine cleavage system found in both prokaryotes and eukaryotes. The Arabidopsis thaliana genome contains three loci for genes encoding H-protein.
Keech, Olivier, Alseekh, Saleh, Boussardon, Clément, Stenlund, Hans, Modde, Katharina, Przybyla-Toscano, Jonathan, Bauwe, Hermann, Juvany, Marta, Valentin, Aurélien, Fernie, Alisdair, R   +9 more
core   +1 more source

The Mechanism of Binding Between the Plasmodium falciparum H-protein and Lipoate Ligase 1 [PDF]

, 2016
Malaria is a devastating tropical disease, accounting for 2 million infections and 440,000 deaths in 2015. The most effective treatment for malaria is chemotherapy to kill the blood stage parasite.
Rodriguez, Ryan E.
core