Results 111 to 120 of about 3,349,944 (177)

Targeting SERPINB3–MAPK axis-mediated cuproptosis resistance enhances the response to antitumor immunotherapy

Molecular Cancer
Cuproptosis, a newly identified form of cell death, is closely linked to copper homeostasis and protein lipoylation. Using a multi-omics approach, we firstly reveal that SERPINB3 confers cuproptosis resistance in pancreatic cancer and functions as a ...
Xiao-Xiao Huang, Cheng-Ke Xie, Yi-Chao Mo, Wei Li, Yong-Ding Wu, Zhi-Yuan Li, Hao-Xiang Zhang, Ge Li, Long Jin, Xin-Quan Lin, Jian-Fei Hu, Yin-Hao Chen, Hong-Yi Lin, Shun-Cang Zhu, Jin-Peng Lu, Hou-Juan Zhu, Wan-Wan Wang, Yi Huang, Zu-Wei Wang, Long Huang, Dan-Feng Wang, Yi-Feng Tian, Cheng-Yu Liao, Shi Chen   +23 more
doaj   +1 more source

Copper-regulated cell death after spinal cord injury: evidence boundaries for non-coding RNA, epigenetics and cuproptosis

Frontiers in Molecular Neuroscience
BackgroundSpinal cord injury (SCI) initiates a secondary-injury cascade involving mitochondrial dysfunction, metal dyshomeostasis, neuroinflammation, and regulated cell death.
Jun Tao, Jun Tao, Jun Tao, Guobing Wang, Guobing Wang, Guobing Wang, Guoying Jiang, Guoying Jiang, Guoying Jiang, Wenqi Feng, Wenqi Feng, Wenqi Feng   +11 more
doaj   +1 more source

A novel role of tRNA-derived fragments in porcine granulosa-oocyte cell communication and cuproptosis.

PLoS Genetics
Copper is essential for reproductive function, yet its accumulation can lead to cytotoxicity and cuproptosis. However, the specific molecular mechanisms underlying granulosa cell cuproptosis and follicular atresia remain unclear.
Linyuan Shen, Xue Zhao, Shuang Wu, Yuhang Lei, Shuang Liang, Saihao Wang, Haodong Dai, Yan Wang, Lei Chen, Ye Zhao, Mailin Gan, Shijun Xiao, Guangbin Zhou, Li Zhu   +13 more
doaj   +1 more source

Enhancing protein-protein docking by new approaches to protein flexibility and scoring of docking hypotheses [PDF]

, 2004
Zöllner FG. Enhancing protein-protein docking by new approaches to protein flexibility and scoring of docking hypotheses. Bielefeld (Germany): Bielefeld University; 2004.Für das Verständnis von biologischen Funktionen können Proteindockingverfahren ...
Frank G. Zöllner, Zöllner, Frank Gerrit   +1 more
core  

Impairment of lipoylation mediated by bromooctanoate targets eukaryotic amidotransferases

Lipoylation is a post-translational modification in which lipoic acid is attached to specific apoproteins of enzyme complexes, like E2 subunits of dehydrogenases or GcvH of the glycine cleavage system.
Costa, Joaquin, Scattolini, Albertina, Pianessi, Tulio L., Mansilla, Maria Cecilia, Uttaro, Antonio Domingo   +4 more
core   +1 more source

Protein Docking mit weichen Volumenmodellen [PDF]

, 2003
Neumann S. Soft volume models for protein-protein docking. Bielefeld (Germany): Bielefeld University; 2003.Der Begriff "Protein Docking" beschreibt die Frage, ob und wie zwei gegebene Proteine interagieren, ausgehend von der 3D Struktur.
Neumann, Steffen
core  

GCS-H2 is essential for growth as it acts as the main relay for mitochondrial lipoylation in heterotrophic tissues of Arabidopsis thaliana

International audienceH-protein is part of the multi-protein glycine cleavage system found in both prokaryotes and eukaryotes. The Arabidopsis thaliana genome contains three loci for genes encoding H-protein.
Keech, Olivier, Alseekh, Saleh, Boussardon, Clément, Stenlund, Hans, Modde, Katharina, Przybyla-Toscano, Jonathan, Bauwe, Hermann, Juvany, Marta, Valentin, Aurélien, Fernie, Alisdair, R   +9 more
core   +1 more source

Sirtuin-regulated lipoylation is an evolutionarily conserved mediator of metabolic health and disease

, 2018
Lipoylation is a rare, but highly conserved lysine posttranslational modification. To date, it is known to occur on only four multimeric metabolic enzymes in mammals, yet these proteins are staples in the core metabolic landscape.
Rowland, Elizabeth
core  

Copper Metabolism-Related Cell Death in Kidney Diseases: Molecular Mechanisms, Disease-Specific Evidence, and Translational Implications. [PDF]

Int J Mol Sci
Shao W, Wang Q, Liu Y, Li L, Li X, Wang X, Cheng F.   +6 more
europepmc   +1 more source

A bacterial enzyme enhances both energy metabolism and health across the life span of <i>C. elegans</i> and mice. [PDF]

Sci Adv
Liu Y, Hu Z, Duan D, Wu L, Zeng AP.
europepmc   +1 more source