Advanced Science, Volume 12, Issue 37, October 6, 2025.This study provides a volumetric engineered 3D drug reservoir to combat diabetic implant infection. Cu‐doped quantum dots induce cuproptosis‐like bacterial death via metabolic collapse, while glucose oxidase triggers hunger‐triggered mitochondrial protection in host cells.
Dize Li +8 more
wiley +1 more source
Immunological and biosynthetic studies of the human pyruvate dehydrogenase complex [PDF]
, 2007 The human pyruvate dehydrogenase multi-enzyme complex (PDC) catalyses the oxidative decarboxylation of pyruvate, transferring the resultant acetyl group to coenzyme A.
Al-Amodi, Hiba Saeed Bagader
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Impaired Mitochondrial Fatty Acid Synthesis Leads to Neurodegeneration in Mice [PDF]
, 2018 There has been a growing interest toward mitochondrial fatty acid synthesis (mtFAS) since the recent discovery of a neurodegenerative human disorder termed MEPAN (mitochondrial enoyl reductase protein associated neurodegeneration), which is caused by ...
Autio, Kaija J. +9 more
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Acute Myocardial Infarction: Molecular Pathogenesis, Diagnosis, and Clinical Management
MedComm, Volume 6, Issue 10, October 2025.Key pathogenic mechanisms in AMI. Oxidative stress and mitochondrial dysfunction induce ROS accumulation, while DAMPs‐PRRs interaction triggers inflammatory cascades. Programmed cell death pathways and epigenetic regulation collectively constitute the core components of AMI pathogenesis.
Mengmeng Zhu +5 more
wiley +1 more source
Journal of Biological Chemistry, 1990 H-protein is a component of the glycine cleavage system loosely associated with the mitochondrial inner membrane and has lipoic acid as a prosthetic group. cDNA clones encoding H-protein were isolated from a bovine liver cDNA library with an oligonucleotide probe from the amino acid sequence of the NH2-terminal region. DNA sequence analysis and deduced
K, Fujiwara +2 more
openaire +2 more sources
Glycine Cleavage System H Protein Is Essential for Embryonic Viability, Implying Additional Function Beyond the Glycine Cleavage System [PDF]
, 2021 Glycine cleavage system H protein (GCSH) is a component of the glycine cleavage system (GCS), a conserved protein complex that acts to decarboxylate glycine.
Copp, AJ +4 more
core
Cuproptosis: lipoylated TCA cycle proteins-mediated novel cell death pathway
Signal Transduction and Targeted Therapy, 2022 Su-Ran Li, Lin-Lin Bu, Lulu Cai
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The 3-hydroxyacyl-ACP dehydratase component of the plant mitochondrial fatty acid synthase system [PDF]
, 2017 We report the characterization of the Arabidopsis 3-hydroxyacyl-acyl carrier protein (ACP) dehydratase (mtHD) component of the mitochondrial fatty acid synthase (mtFAS) system, encoded by AT5G60335. The mitochondrial localization and catalytic capability
Guan, Xin +11 more
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Mitochondria as a primary determinant of angiogenic modality in pulmonary arterial hypertension. [PDF]
Impaired pulmonary angiogenesis plays a pivotal role in the progression of pulmonary arterial hypertension (PAH) and patient mortality, yet the molecular mechanisms driving this process remain enigmatic.
Baggett, Brenda +11 more
core +1 more source
Lipoylating and biotinylating enzymes contain a homologous catalytic module [PDF]
, 2000 Biotin and lipoic acid moieties are the covalently attached coenzyme cofactors of several multicomponent enzyme complexes that catalyze key metabolic reactions.
Reche Gallardo, Pedro Antonio
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