Protein Palmitoylation Modification During Viral Infection and Detection Methods of Palmitoylated Proteins [PDF]
Frontiers in Cellular and Infection Microbiology, 2022 Protein palmitoylation—a lipid modification in which one or more cysteine thiols on a substrate protein are modified to form a thioester with a palmitoyl group—is a significant post-translational biological process. This process regulates the trafficking,
Xiaoling Li +5 more
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Protein palmitoylation in cancer: molecular functions and therapeutic potential [PDF]
Molecular Oncology, 2023 Protein S‐palmitoylation (hereinafter referred to as protein palmitoylation) is a reversible lipid posttranslational modification catalyzed by the zinc finger DHHC‐type containing (ZDHHC) protein family.
Binhui Zhou +3 more
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Diverse Roles of Protein Palmitoylation in Cancer Progression, Immunity, Stemness, and Beyond [PDF]
Cells, 2023 Protein S-palmitoylation, a type of post-translational modification, refers to the reversible process of attachment of a fatty acyl chain—a 16-carbon palmitate acid—to the specific cysteine residues on target proteins.
Mingli Li, Leisi Zhang, Chun-Wei Chen
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Global, site-specific analysis of neuronal protein S-acylation [PDF]
Scientific Reports, 2017 Protein S-acylation (palmitoylation) is a reversible lipid modification that is an important regulator of dynamic membrane-protein interactions. Proteomic approaches have uncovered many putative palmitoylated proteins however, methods for comprehensive ...
Mark O. Collins +2 more
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Protein palmitoylation: an emerging regulator of inflammatory signaling and diseases [PDF]
Frontiers in ImmunologyProtein palmitoylation is a reversible lipid modification in which palmitoyl esters are covalently attached to cysteine residues of proteins. It controls various cellular physiological processes and alters protein stability, conformation, localization ...
Rong Chen +6 more
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Protein Palmitoylation Regulates Cell Survival by Modulating XBP1 Activity in Glioblastoma Multiforme [PDF]
Molecular Therapy: Oncolytics, 2020 Glioblastoma multiforme (GBM) almost invariably acquires an invasive phenotype, resulting in limited therapeutic options. Protein palmitoylation markedly affects tumorigenesis and malignant progression in GBM.
Xueran Chen +9 more
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Protein Palmitoylation in Bovine Ovarian Follicle. [PDF]
Int J Mol Sci, 2021 Protein palmitoylation is a reversible post-translational modification by fatty acids (FA), mainly a palmitate (C16:0). Palmitoylation allows protein shuttling between the plasma membrane and cytosol to regulate protein stability, sorting and signaling activity and its deficiency leads to diseases.
Uzbekova S +8 more
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Protein palmitoylation is involved in regulating mouse sperm motility via the signals of calcium, protein tyrosine phosphorylation and reactive oxygen species [PDF]
Biological ResearchBackground Protein palmitoylation, a critical posttranslational modification, plays an indispensable role in various cellular processes, including the regulation of protein stability, mediation of membrane fusion, facilitation of intracellular protein ...
Yuping Xiong +5 more
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Protein palmitoylation: biological functions, disease, and therapeutic targets [PDF]
MedCommProtein palmitoylation, a reversible post‐translational lipid modification, is catalyzed by the ZDHHC family of palmitoyltransferases and reversed by several acyl protein thioesterases, regulating protein localization, accumulation, secretion, and ...
Yan‐Ran Qian +2 more
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Protein palmitoylation and cancer. [PDF]
EMBO Rep, 2018 Protein S-palmitoylation is a reversible post-translational modification that alters the localization, stability, and function of hundreds of proteins in the cell. S-palmitoylation is essential for the function of both oncogenes (e.g., NRAS and EGFR) and tumor suppressors (e.g., SCRIB, melanocortin 1 receptor).
Ko PJ, Dixon SJ.
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