Results 1 to 10 of about 894,703 (310)

Protein phosphatase 2 regulatory subunit B''Alpha silencing inhibits tumor cell proliferation in liver cancer [PDF]

Cancer Medicine, 2019
Aim To explore the effects of protein phosphatase 2 regulatory subunit B''Alpha (PPP2R3A) on the proliferation and migration of liver cancer cells. Methods Expression of PPP2R3A in tumor tissues of hepatocellular carcinoma (HCC) patients was detected by ...
Huijuan Chen, Jing Xu, Peixiao Wang, Qingming Shu, Lihong Huang, Jing Guo, Xuyi Zhang, Hongying Zhang, Ying Wang, Zhongyang Shen, Xinguo Chen, Qing Zhang   +11 more
doaj   +2 more sources

Adaptation to glucose starvation is associated with molecular reorganization of the circadian clock in Neurospora crassa

eLife, 2023
The circadian clock governs rhythmic cellular functions by driving the expression of a substantial fraction of the genome and thereby significantly contributes to the adaptation to changing environmental conditions.
Anita Szőke, Orsolya Sárkány, Géza Schermann, Orsolya Kapuy, Axel CR Diernfellner, Michael Brunner, Norbert Gyöngyösi, Krisztina Káldi   +7 more
doaj   +1 more source

Protein phosphatase 2A holoenzymes regulate leucine-rich repeat kinase 2 phosphorylation and accumulation

Neurobiology of Disease, 2021
LRRK2 is a highly phosphorylated multidomain protein and mutations in the gene encoding LRRK2 are a major genetic determinant of Parkinson's disease (PD).
Matthieu Drouyer, Marc F. Bolliger, Evy Lobbestael, Chris Van den Haute, Marco Emanuele, Réginald Lefebvre, William Sibran, Tina De Wit, Coline Leghay, Eugénie Mutez, Nicolas Dzamko, Glenda M. Halliday, Shigeo Murayama, Alain Martoriati, Katia Cailliau, Jean-François Bodart, Marie-Christine Chartier-Harlin, Veerle Baekelandt, R. Jeremy Nichols, Jean-Marc Taymans   +19 more
doaj   +1 more source

Identification of a protein phosphatase-1/phospholamban complex that is regulated by cAMP-dependent phosphorylation. [PDF]

PLoS ONE, 2013
In human and experimental heart failure, the activity of the type 1 phosphatase is significantly increased, associated with dephosphorylation of phospholamban, inhibition of the sarco(endo)plasmic reticulum Ca(2+) transport ATPase (SERCA2a) and depressed
Elizabeth Vafiadaki, Demetrios A Arvanitis, Despina Sanoudou, Evangelia G Kranias   +3 more
doaj   +1 more source

Microcystins: Potent xenobiotics [PDF]

Archive of Oncology, 2011
Having in mind that exposure to low levels of microcystin in drinking water represents the health risk for people, microcystins can be observed as potent xenobiotics.
Ilić Maja, Svirčev Zorica, Baltić Vladimir   +2 more
doaj   +1 more source

Protein tyrosine phosphatase nonreceptor type 2 controls colorectal cancer development [PDF]

Journal of Clinical Investigation, 2021
Protein tyrosine phosphatase nonreceptor type 2 (PTPN2) recently emerged as a promising cancer immunotherapy target. We set out to investigate the functional role of PTPN2 in the pathogenesis of human colorectal carcinoma (CRC), as its role in immune-silent solid tumors is poorly understood.
Katkeviciute, Egle, Hering, Larissa, Montalban-Arques, Ana, Busenhart, Philipp, Schwarzfischer, Marlene, Manzini, Roberto, Conde, Javier, Atrott, Kirstin, Lang, Silvia, Rogler, Gerhard, Naschberger, Elisabeth, Schellerer, Vera S, Stürzl, Michael, Rickenbacher, Andreas, Turina, Matthias, Weber, Achim, Leibl, Sebastian, Leventhal, Gabriel E, Levesque, Mitchell Paul, Boyman, Onur, Scharl, Michael, Spalinger, Marianne R   +21 more
openaire   +2 more sources

Protein phosphatase-1 inhibitor-2 promotes PP1γ positive regulation of synaptic transmission

Frontiers in Synaptic Neuroscience, 2022
Inhibitor-2 (I-2) is a prototypic inhibitor of protein phosphatase-1 (PP1), a major serine-threonine phosphatase that regulates synaptic plasticity and learning and memory.
Karl Foley, Karl Foley, Haider Altimimi, Hailong Hou, Yu Zhang, Cody McKee, Cody McKee, Makaía M. Papasergi-Scott, Hongtian Yang, Abigail Mayer, Nancy Ward, David M. MacLean, Angus C. Nairn, David Stellwagen, Houhui Xia, Houhui Xia   +15 more
doaj   +1 more source

Bone morphogenetic protein 2: heterologous expression and potential in bone regeneration

Actualidades Biológicas, 2021
Currently, bone morphogenetic protein 2 (BMP-2) is one of the two osteoinductive growth factors used in medical devices to promote bone formation. Typically, this protein is bought from commercial houses at high rates and in small quantities that are not
Andrea Mesa-Restrepo, Juan Fernando-Alzate, Edwin Bairon Patiño-Gonzalez   +2 more
doaj   +1 more source

PPM1D Knockdown Suppresses Cell Proliferation, Promotes Cell Apoptosis, and Activates p38 MAPK/p53 Signaling Pathway in Acute Myeloid Leukemia

Technology in Cancer Research & Treatment, 2020
Objectives: This study was to explore the effect of protein phosphatase, Mg 2+ /Mn 2+ dependent 1D knockdown on proliferation and apoptosis as well as p38 MAPK/p53 signaling pathway in acute myeloid leukemia.
Bin Li MD, Jie Hu MD, Di He BS, Qi Chen MD, Suna Liu BS, Xiaoling Zhu MD, Meijia Yu MD   +6 more
doaj   +1 more source

Establishment of a PPP2CA homozygous knockout human embryonic stem cell line via CRISPR/Cas9 system

Stem Cell Research, 2023
Protein phosphatase 2A (PPP2CA) is one of the four main Ser/Thr phosphatase enzymes, which involved in the negative control of cell growth and division. PPP2CA is the main protein phosphatase in the heart, which regulates Ca (2+) through a series of ion ...
Tongbin Ding, Zhe Gao, Hang Liu, Yuan Li, Shichao Liu, Liguo Jian   +5 more
doaj   +1 more source