Results 261 to 270 of about 894,703 (310)

Nurr1 Orchestrates Claustrum Development and Functionality

Advanced Science, EarlyView.
Nurr1 (Nr4a2) is the master transcription factor to control claustrum morphogenesis and cell fate decision postmitotically by inhibiting intracellular G‐protein signaling. Nurr1 deficiency alters the transcriptomic profiles of subcortical claustral neurons into neocortical insular neurons, resulting in defected claustrum development, impaired axonal ...
Kuo Yan, Andrew G. Newman, Pauline Lange, Susanne Müller, Marco Foddis, Stefan Paul Koch, Philipp Böhm‐Sturm, Maron Mantwill, Carsten Finke, Penghui Deng, Melissa Long, Dietmar Schmitz, Victor Tarabykin   +12 more
wiley   +1 more source

Lack of striatal-enriched protein tyrosine phosphatase affected the serotonin system, behavior, and brain morphology in mice. [PDF]

Front Psychiatry
Moskaliuk V, Komleva P, Khotskin N, Arefieva A, Shevelev O, Korablev A, Serova I, Battulin N, Kulikov A, Naumenko V, Bazovkina D, Kulikova E.   +11 more
europepmc   +1 more source

Hyperviscous Diabetic Bone Marrow Niche Impairs BMSCs Osteogenesis via TRPV2‐Mediated Cytoskeletal‐Nuclear Mechanotransduction

Advanced Science, EarlyView.
Diabetic bone marrow exhibits pathological ECM hyperviscosity that activates TRPV2‐mediated Ca2⁺ influx, leading to perinuclear F‐actin disassembly, nuclear deformation, and chromatin condensation. This cytoskeletal‐nuclear decoupling suppresses osteogenic differentiation of BMSCs.
Yao Wen, Xinhui Zheng, Jieliu Li, Minyu He, Dongqi Fan, Xingyu Zhu, Qiming Zhai, Liangjing Xin, Tao Chen   +8 more
wiley   +1 more source

DEL‐1 is an Endogenous Senolytic Protein that Inhibits Senescence‐Associated Bone Loss

Advanced Science, EarlyView.
Senescent bone marrow stromal cells accumulate in the aging bone microenvironment, promoting bone degeneration. DEL‐1, an endogenous secreted protein, acts as a natural senolytic that selectively eliminates these cells. By engaging a β3 integrin/CD73/adenosine/p38 MAPK/BCL‐2 pathway, DEL‐1 counters aging‐related bone loss, revealing promising ...
Jong‐Hyung Lim, Kridtapat Sirisereephap, Hui Wang, Giulia Trimaglio, Kyoung‐Jin Chung, Jonathan Korostoff, Tetsuhiro Kajikawa, Xiaofei Li, Meircurius D.C. Surboyo, Tomoki Maekawa, Triantafyllos Chavakis, George Hajishengallis   +11 more
wiley   +1 more source

Targeting PTPN22 at Nonorthosteric Binding SitesA Fragment Approach. [PDF]

ACS Omega
Di Lello P, Wells MM, Davis B, Daniels Z, Garner TP, Gazzard L, Harris R, Hubbard RE, Landry ML, Martin B, Morgan JLW, Patapoff A, Simmonite H, Skelton N, Ultsch M, Walters BT, Wu P, Dimitrova YN, Huard K.   +18 more
europepmc   +1 more source

Engineered Mesenchymal Stem Cell–NK Cell Complexes for Spatially Targeted and Functionally Revitalized Cancer Immunotherapy

Advanced Science, EarlyView.
IL‐15‐engineered stem cell–NK cell complexes, assembled via bioorthogonal chemistry, enable effective lung cancer immunotherapy. Abstract Natural killer (NK) cells represent a powerful immunotherapeutic strategy due to their intrinsic cytotoxicity and ability to target tumor cells independently of antigen presentation.
Qian Zhang, Bo Yin, Munaiwaier Sabier, Youlan Yang, Mengling Wu, Zhouping Zhao, Xuanzhi Luo, Yuehong Zhong, Xiuming Zhu, Jie Zhang, Jing Wang, Kai Chen, Fei Ruan, Wei Zhang, Zhimin Lu, Jiong Wang   +15 more
wiley   +1 more source

PTPN18 functions as a tumor suppressor in breast cancer by negatively regulating cyclin E. [PDF]

Int J Oncol
Zhang N, Wang T, Bai B, Zhang X, Xu W, Chen W, Yu Y, Wang B.   +7 more
europepmc   +1 more source

A truncated CDC14A retains catalytic structure and phosphatase activity preserving male fertility but causes nonsyndromic deafness. [PDF]

J Biol Chem
Shabbir K, Jackisch G, Belyantseva IA, Imran M, Naz S, Sele C, Murina V, Knecht W, Friedman TB, Logan DT, Imtiaz A.   +10 more
europepmc   +1 more source

PP2A activation targets MYCN in neuroblastoma. [PDF]

Cell Death Dis
Nazam N, Manzoor S, Shaikh M, Brown ML, Julson JR, Quinn CH, Butey S, Shirley SN, Aye JM, Yoon K, Leavenworth JW, Ohlmeyer M, Beierle EA.   +12 more
europepmc   +1 more source