Results 271 to 280 of about 894,703 (310)

HMBOX1 inhibits hepatocellular carcinoma progression via PTPN1 mediated AKT1 phosphorylation. [PDF]

Oncol Rep
Zhang C, Jiang Y, Liu J, Zhang W, Qi J, Wen Q, Zhao H.   +6 more
europepmc   +1 more source

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Anp32e (Cpd1) and related protein phosphatase 2 inhibitors

The Cerebellum, 2003
Mouse Anp32e (Acidic leucine-rich nuclear phosphoprotein 32 family, member e: NM_023210, P97822, formerly Cpd1), a protein identified in postnatal cerebellum by differential display, belongs to the superfamily of leucine rich repeat (LRR) proteins and to the Acidic Nuclear Phosphoprotein 32 (ANP32) family of protein phosphatase 2 (PPP2, formerly PP2A ...
openaire   +2 more sources

Inhibitor Binding Sites in the Protein Tyrosine Phosphatase SHP-2

Mini-Reviews in Medicinal Chemistry, 2020
Protein tyrosine phosphatase 2 (SHP-2) has long been proposed as a cancer drug target. Several small-molecule compounds with different mechanisms of SHP-2 inhibition have been reported, but none are commercially available. Pool selectivity over protein tyrosine phosphatase 1 (SHP-1) and a lack of cellular activity have hindered the development of ...
Haonan Zhang, Zhengquan Gao, Chunxiao Meng, Xiangqian Li, Dayong Shi   +4 more
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SHP-2, SH2-containing protein tyrosine phosphatase-2.

The international journal of biochemistry & cell biology, 1998
SHP-2 is an ubiquitously expressed cytosolic protein tyrosine phosphatase composed of two amino-terminal SH2 domains, a central phosphatase domain and a carboxy-terminal tail. Upon activation of cells with different stimuli, SHP-2 is recruited to the plasma membrane where it can associate with a number of tyrosine phosphorylated molecules, including ...
M, Stein-Gerlach, C, Wallasch, A, Ullrich   +2 more
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Specific dephosphorylation of Janus Kinase 2 by protein tyrosine phosphatases

PROTEOMICS, 2014
Many protein kinases are activated through phosphorylation of an activation loop thereby turning on downstream signaling pathways. Activation of JAK2, a nonreceptor tyrosine kinase with an important role in growth factor and cytokine signaling, requires phosphorylation of the 1007 and 1008 tyrosyl residues.
Jianzhuo, Li, Xidong, Liu, Huiying, Chu, Xueqi, Fu, Tianbao, Li, Lianghai, Hu, Shu, Xing, Guohui, Li, Jingkai, Gu, Zhizhuang Joe, Zhao   +9 more
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Protein tyrosine phosphatase-1B and T-cell protein tyrosine phosphatase regulate IGF-2-induced MCF-7 cell migration

Biochemical and Biophysical Research Communications, 2010
The protein tyrosine phosphatase-1B (PTP1B) and the T-cell protein tyrosine phosphatase (TC-PTP) have been implicated in down-regulation of tyrosine kinase receptors, conferring anti-oncogenic functions to these PTPases. However, recent work has shown that PTP1B is positively implicated in oncogenic properties of breast cancer cells by regulating the ...
Christophe, Blanquart, Salah-Eddine, Karouri, Tarik, Issad   +2 more
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