Results 71 to 80 of about 894,703 (310)

Protein Tyrosine Phosphatase SHP-2 (PTPN11) in Hematopoiesis and Leukemogenesis [PDF]

Journal of Signal Transduction, 2011
SHP-2 (PTPN11), a ubiquitously expressed protein tyrosine phosphatase, is critical for hematopoietic cell development and function owing to its essential role in growth factor/cytokine signaling. More importantly, germline and somatic mutations in this phosphatase are associated with Noonan syndrome, Leopard syndrome, and childhood hematologic ...
Liu, Xia, Qu, Cheng-Kui
openaire   +2 more sources

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Genome-wide identification and expression analysis of the PP2C gene family in Apocynum venetum and Apocynum hendersonii

BMC Plant Biology
Background Protein phosphatase class 2 C (PP2C) is the largest protein phosphatase family in plants. Members of the PP2C gene family are involved in a variety of physiological pathways in plants, including the abscisic acid signalling pathway, the ...
Jiayi Chen, Yue Wang, Yongmei Wu, Xiaoyu Huang, Xiaojun Qiu, Jikang Chen, Qian Lin, Haohan Zhao, Fengming Chen, Gang Gao   +9 more
doaj   +1 more source

SHIP2 inhibition alters redox‐induced PI3K/AKT and MAP kinase pathways via PTEN over‐activation in cervical cancer cells

FEBS Open Bio, 2020
Phosphatidylinositol (3,4,5)‐trisphosphate (PI(3,4,5)P3) is required for protein kinase B (AKT) activation. The level of PI(3,4,5)P3 is constantly regulated through balanced synthesis by phosphoinositide 3‐kinase (PI3K) and degradation by ...
Abdelhalim Azzi
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Expansive evolution of the TREHALOSE-6-PHOSPHATE PHOSPHATASE gene family in Arabidopsis [PDF]

, 2012
Trehalose is a nonreducing sugar used as a reserve carbohydrate and stress protectant in a variety of organisms. While higher plants typically do not accumulate high levels of trehalose, they encode large families of putative trehalose biosynthesis genes.
Avonce, Nelson, Beeckman, Tom, Feil, Regina, Lammens, Willem, Lopez Galvis, Lorena, Lunn, John E, Maere, Steven, Rolland, Filip, Van Dijck, Patrick, Vandesteene, Lies, Vanneste, Kevin   +10 more
core   +2 more sources

A RP-UFLC Assay for Protein Tyrosine Phosphatases: Focus on Protein Tyrosine Phosphatase Non-Receptor Type 2 (PTPN2) [PDF]

Scientific Reports, 2015
AbstractProtein tyrosine phosphatases (PTPs) are involved in numerous signaling pathways and dysfunctions of certain of these enzymes have been linked to several human diseases including cancer and autoimmune diseases. PTPN2 is a PTP mainly expressed in hematopoietic cells and involved in growth factor and JAK/STAT signaling pathways.
Duval, Romain, Bui, Linh-Chi, Berthelet, Jérémy, Dairou, Julien, Mathieu, Cécile, Guidez, Fabien, Dupret, Jean-Marie, Cools, Jan, Chomienne, Christine, Rodrigues-Lima, Fernando   +9 more
openaire   +3 more sources

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

Protein Kinases and Phosphatases of the Plastid and Their Potential Role in Starch Metabolism

Frontiers in Plant Science, 2018
Phospho-proteomic studies have confirmed that phosphorylation is a common mechanism to regulate protein function in the chloroplast, including the enzymes of starch metabolism.
Chris White-Gloria, Jayde J. Johnson, Kayla Marritt, Amr Kataya, Amr Kataya, Ahmad Vahab, Greg B. Moorhead   +6 more
doaj   +1 more source

Frequent mutation of receptor protein tyrosine phosphatases provides a mechanism for STAT3 hyperactivation in head and neck cancer [PDF]

, 2014
The underpinnings of STAT3 hyperphosphorylation resulting in enhanced signaling and cancer progression are incompletely understood. Loss-of-function mutations of enzymes that dephosphorylate STAT3, such as receptor protein tyrosine phosphatases, which ...
Bahar, Ivet, Du, Yu, Garraway, Levi A., General, Ignacio, Gilbert, Breean R., Grandis, Jennifer R., Hammerman, Peter S., Hritz, Jozef, Johnson, Daniel E., Ju, Zhenlin, Li, Hua, Lu, Yiling, Lui, Vivian Wai Yan, Mills, Gordon B., Ng, Patrick Kwok-Shing, Pendleton, Kelsey P., Peyser, Noah D., Vries, John K., Wang, Lin, Wang, Zhenghe, Xiao, Xiao, Zeng, Yan   +21 more
core   +1 more source