Results 1 to 10 of about 334,240 (268)
Amyloid precursor protein induces reactive astrogliosis
Acta Physiologica, 2023 AbstractAimAstrocytes respond to stressors by acquiring a reactive state characterized by changes in their morphology and function. Molecules underlying reactive astrogliosis, however, remain largely unknown. Given that several studies observed increase in the Amyloid Precursor Protein (APP) in reactive astrocytes, we here test whether APP plays a role
Gretsen Velezmoro Jauregui +20 more
openaire +6 more sources
Identification of General and Heart-Specific miRNAs in Sheep (Ovis aries).
PLoS ONE, 2015 MicroRNAs (miRNAs or miRs) are small regulatory RNAs crucial for modulation of signaling pathways in multiple organs. While the link between miRNAs and heart disease has grown more readily apparent over the past three years, these data are primarily ...
Alessandro Laganà +6 more
doaj +1 more source
Scientific Reports, 2021 The pro-homeostatic lipid mediators elovanoids (ELVs) attenuate cell binding and entrance of the SARS-CoV-2 receptor-binding domain (RBD) as well as of the SARS-CoV-2 virus in human primary alveoli cells in culture.
Jorgelina M. Calandria +10 more
doaj +1 more source
Amyloid Precursor Protein and Alzheimer’s Disease
International Journal of Molecular Sciences, 2023 Alzheimer’s disease (AD) is one of the most common neurodegenerative disorders associated with age or inherited mutations. It is characterized by severe dementia in the late stages that affect memory, cognitive functions, and daily life overall. AD progression is linked to the accumulation of cytotoxic amyloid beta (Aβ) and hyperphosphorylated tau ...
Kseniia S. Orobets, Andrey L. Karamyshev
openaire +2 more sources
Lactic acid promotes metastatic niche formation in bone metastasis of colorectal cancer
Cell Communication and Signaling, 2021 Background To investigate the effect of lactic acid (LA) on the progression of bone metastasis from colorectal cancer (CRC) and its regulatory effects on primary CD115 (+) osteoclast (OC) precursors.
Jin Qian +14 more
doaj +1 more source
Harčova Nauka ì Tehnologìâ, 2018 The article considers the possibility of obtaining purified fractions-precursors of bioactive peptides from milk proteins by the method of preparative electrophoresis.
V. Yukalo +3 more
doaj +1 more source
The aPKC-CBP Pathway Regulates Post-stroke Neurovascular Remodeling and Functional Recovery
Stem Cell Reports, 2017 Summary: Epigenetic modifications have emerged as attractive molecular substrates that integrate extrinsic changes into the determination of cell identity.
Ayden Gouveia +10 more
doaj +1 more source
Structural determinants of Arabidopsis thaliana Hyponastic leaves 1 function in vivo. [PDF]
PLoS ONE, 2014 MicroRNAs have turned out to be important regulators of gene expression. These molecules originate from longer transcripts that are processed by ribonuclease III (RNAse III) enzymes. Dicer proteins are essential RNAse III enzymes that are involved in the
Paula Burdisso +5 more
doaj +1 more source
Protein transduction from retroviral Gag precursors [PDF]
Proceedings of the National Academy of Sciences, 2010 Retroviral particles assemble a few thousand units of the Gag polyproteins. Proteolytic cleavage mediated by the retroviral protease forms the bioactive retroviral protein subunits before cell entry. We hypothesized that this process could be exploited for targeted, transient, and dose-controlled transduction of nonretroviral proteins into cultured ...
Voelkel, Christine +9 more
openaire +2 more sources
Food Science and Human WellnessTrimethylamine N-oxide (TMAO) is a risk factor of various chronic diseases, which was produced by metabolism from precursors to trimethylamine (TMA) in gut and the oxidation from TMA in liver.
Chengcheng Wang +7 more
doaj +1 more source