Results 1 to 10 of about 322,759 (220)

In silico evidence that protein unfolding is as a precursor of the protein aggregation [PDF]

ChemPhysChem 2020, 21, 377, 2019
We present a computational study on the folding and aggregation of proteins in aqueous environment, as function of its concentration. We show how the increase of the concentration of individual protein species can induce a partial unfolding of the native conformation without the occurrence of aggregates. A further increment of the protein concentration
Valentino Bianco, Giancarlo Franzese, Ivan Coluzza   +2 more
arxiv   +9 more sources

Precursor Protein for Newcastle Disease Virus [PDF]

Journal of Virology, 1973
The course of viral protein synthesis during infection of chicken embryo fibroblasts with Newcastle disease virus (NDV) L. Kansas has been followed by using sodium dodecyl sulfate polyacrylamide gel electrophoresis. Of the three major virion polypeptide molecular weight classes, I (78,400 daltons), II (53,500 daltons), and III (37,600 daltons), only II,
A. C. R. Samson, Colin Fox
openalex   +5 more sources

Protocol for assessing the clogging of the mitochondrial translocase of the outer membrane by precursor proteins in human cells [PDF]

STAR Protocols
Summary: Protein import into the mitochondria is required for organellar function. Inefficient import can result in the stalling of mitochondrial precursors inside the translocase of the outer membrane (TOM) and blockage of the mitochondrial entry gate ...
John Kim, Hilla Weidberg
doaj   +2 more sources

Endoplasmic reticulum stress and rhodopsin accumulation in an organoid model of Retinitis Pigmentosa carrying a RHO pathogenic variant [PDF]

Stem Cell Research & Therapy
Background Retinitis Pigmentosa (RP) is the most prevalent inherited retinal dystrophy, with more than 120 causative genes. Among them, RHO was the first photoreceptor gene described to harbor mutations responsible for RP. RHO pathogenic variants usually
Arnau Navinés-Ferrer, Esther Pomares
doaj   +2 more sources

Understanding the Effects of Trenbolone Acetate, Polyamine Precursors, and Polyamines on Proliferation, Protein Synthesis Rates, and the Abundance of Genes Involved in Myoblast Growth, Polyamine Biosynthesis, and Protein Synthesis in Murine Myoblasts

Biology, 2023
Research suggests that androgens increase skeletal muscle growth by modulating polyamine biosynthesis. As such, the objective of this study was to investigate effects of anabolic hormones, polyamine precursors, and polyamines relative to proliferation ...
Laura A. Motsinger, Lillian L. Okamoto, Nikole E. Ineck, Brynne A. Udy, Christopher L. Erickson, Youssef Harraq, Caleb C. Reichhardt, Gordon K. Murdoch, Kara Jean Thornton   +8 more
doaj   +1 more source

Chloroplast precursor protein translocon [PDF]

FEBS Letters, 1999
Chloroplasts are believed to have originated from a photosynthetic, prokaryotic ancestor. As the result of endosymbiotic evolution, most of the genes of the endocytobiont were displaced to the host nucleus. Today's chloroplasts must import most of their proteins from the cytosol as precursors.
Jürgen Soll, Timo May
openaire   +3 more sources

Enzymes in the Cholesterol Synthesis Pathway: Interactomics in the Cancer Context

Biomedicines, 2021
A global protein interactome ensures the maintenance of regulatory, signaling and structural processes in cells, but at the same time, aberrations in the repertoire of protein–protein interactions usually cause a disease onset.
Pavel Ershov, Leonid Kaluzhskiy, Yuri Mezentsev, Evgeniy Yablokov, Oksana Gnedenko, Alexis Ivanov   +5 more
doaj   +1 more source

Functional requirements for a Samd14-capping protein complex in stress erythropoiesis

eLife, 2022
Acute anemia induces rapid expansion of erythroid precursors and accelerated differentiation to replenish erythrocytes. Paracrine signals—involving cooperation between stem cell factor (SCF)/Kit signaling and other signaling inputs—are required for the ...
Suhita Ray, Linda Chee, Yichao Zhou, Meg A Schaefer, Michael J Naldrett, Sophie Alvarez, Nicholas T Woods, Kyle J Hewitt   +7 more
doaj   +1 more source

Nucleation precursors in protein crystallization [PDF]

Acta Crystallographica Section F Structural Biology Communications, 2014
Protein crystal nucleation is a central problem in biological crystallography and other areas of science, technology and medicine. Recent studies have demonstrated that protein crystal nuclei form within crucial precursors. Here, methods of detection and characterization of the precursors are reviewed: dynamic light scattering, atomic force microscopy ...
Peter G. Vekilov, Maria A. Vorontsova
openaire   +3 more sources

Recent Advances in Chemical Biology Using Benzophenones and Diazirines as Radical Precursors

Molecules, 2020
The use of light-activated chemical probes to study biological interactions was first discovered in the 1960s, and has since found many applications in studying diseases and gaining deeper insight into various cellular mechanisms involving protein ...
Muhammad Murtaza Hassan, Olasunkanmi O. Olaoye   +1 more
doaj   +1 more source