Results 21 to 30 of about 32,326 (169)
Single prenyl-binding site on protein prenyl transferases [PDF]
Proceedings of the National Academy of Sciences, 1998 Three distinct protein prenyl transferases, one protein farnesyl transferase (FTase) and two protein geranylgeranyl transferases (GGTase), catalyze prenylation of many cellular proteins. One group of protein substrates contains a C-terminal C AAX motif (C is Cys, A is aliphatic, and
L, Desnoyers, M C, Seabra
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Specific Disruption of Ras2 CAAX Proteolysis Alters Its Localization and Function
Microbiology Spectrum, 2023 Many CAAX proteins, such as Ras GTPase, undergo a series of posttranslational modifications at their carboxyl terminus (i.e., cysteine prenylation, endoproteolysis of AAX, and carboxylmethylation).
Rajani Ravishankar +6 more
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PLoS ONE, 2022 Protein prenylation by farnesyltransferase (FTase) is often described as the targeting of a cysteine-containing motif (CaaX) that is enriched for aliphatic amino acids at the a1 and a2 positions, while quite flexible at the X position.
Brittany M Berger +6 more
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PLoS Biology, 2023 The prenylated form of the human 2'-5'-oligoadenylate synthetase 1 (OAS1) protein has been shown to potently inhibit the replication of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the virus responsible for the Coronavirus Disease 2019 ...
Spyros Lytras +11 more
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Cloning and Characterization of Protein Prenyltransferase Alpha Subunit in Rice
Rice Science, 2021 Protein prenylation plays a crucial role in plant development and stress response. We report the function of prenyltransferase α-subunit in rice. Protein-protein interactions showed that the farnesyl- transferase (OsPFT)/geranylgeranyltransferase-I ...
Wang Tao +4 more
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Statin treatment increases lifespan and improves cardiac health in Drosophila by decreasing specific protein prenylation. [PDF]
PLoS ONE, 2012 Statins such as simvastatin are 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors and standard therapy for the prevention and treatment of cardiovascular diseases in mammals.
Stephen R Spindler +9 more
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Protein prenylation in spinach chloroplasts [PDF]
Proceedings of the National Academy of Sciences, 1999 Protein prenylation in plants was studied by in vivo metabolic 3 H-mevalonate labeling in combination with a range of protein synthesis inhibitors. In spinach cotyledons, this posttranslational protein modification was found to be divided into two categories, one representing the conventional
I, Parmryd, B, Andersson, G, Dallner
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Protein prenylation in Schizosaccharomyces pombe [PDF]
FEBS Letters, 1992 S. pombe is shown to be a powerful system for studies concerning attachment or polyisoprenoid moieties to proteins, due to its ability to take up exogenous mevalonic acid efficiently. The fission yeast can take up about 5% of the exogenously added mevalonic acid and incorporate ∼10% of this into protein.
Giannakouros, Thomas +2 more
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Rab GTPase prenylation hierarchy and its potential role in choroideremia disease. [PDF]
PLoS ONE, 2013 Protein prenylation is a widespread post-translational modification in eukaryotes that plays a crucial role in membrane targeting and signal transduction. RabGTPases is the largest group of post-translationally C-terminally geranylgeranylated.
Monika Köhnke +8 more
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Combinatorial Modulation of Protein Prenylation [PDF]
ACS Chemical Biology, 2007 The cell has >60 different farnesylated proteins. Many critically important signal transduction proteins are post-translationally modified with attachment of a farnesyl isoprenoid catalyzed by protein farnesyltransferase (FTase). Recently, it has been shown that farnesyl diphosphate (FPP) analogues can alter the peptide substrate specificity of FTase ...
Amanda J, Krzysiak +7 more
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