Results 41 to 50 of about 4,957,023 (387)

Coevolutionary Analysis of Protein Subfamilies by Sequence Reweighting

Entropy, 2019
Extracting structural information from sequence co-variation has become a common computational biology practice in the recent years, mainly due to the availability of large sequence alignments of protein families.
Duccio Malinverni, Alessandro Barducci
doaj   +1 more source

Real or fake? Measuring the impact of protein annotation errors on estimates of domain gain and loss events

Frontiers in Bioinformatics, 2023
Protein annotation errors can have significant consequences in a wide range of fields, ranging from protein structure and function prediction to biomedical research, drug discovery, and biotechnology.
Arnaud Kress, Olivier Poch, Odile Lecompte, Julie D. Thompson   +3 more
doaj   +1 more source

Analysis of protein chameleon sequence characteristics [PDF]

Bioinformation, 2009
Conversion of local structural state of a protein from an alpha-helix to a beta-strand is usually associated with a major change in the tertiary structure. Similar changes were observed during the self assembly of amyloidogenic proteins to form fibrils, which are implicated in severe diseases conditions, e.g., Alzheimer disease. Studies have emphasized
Ghozlane, Amine, Joseph, Agnel, Bornot, Aurélie, de Brevern, Alexandre   +3 more
openaire   +3 more sources

BMC Caller: a webtool to identify and analyze bacterial microcompartment types in sequence data

Biology Direct, 2022
Bacterial microcompartments (BMCs) are protein-based organelles found across the bacterial tree of life. They consist of a shell, made of proteins that oligomerize into hexagonally and pentagonally shaped building blocks, that surrounds enzymes ...
Markus Sutter, Cheryl A. Kerfeld
doaj   +1 more source

A Receptor Component of the Chloroplast Protein Translocation Machinery [PDF]

, 1994
The chloroplast outer envelope protein OEP86 functions as a receptor in precursor protein translocation into chloroplasts. Sequence analysis suggests that the precursor of OEP86 is directed to the chloroplast outer envelope by a cleavable, negatively ...
Heemeyer, Frank, Heijne, Gunnar von, Hirsch, Stephan, Muckel, Eva, Soll, Jürgen   +4 more
core   +1 more source

PhosHSGN: Deep Neural Networks Combining Sequence and Protein Spatial Information to Improve Protein Phosphorylation Site Prediction

IEEE Access
Phosphorylation site prediction is one of the key processes in protein post-transcriptional modification. It is an important research direction in the field of bioinformatics and is of great significance for understanding protein function and signal ...
Jiale Lu, Haibin Chen, Ji Qiu
doaj   +1 more source

iSeqSearch: incremental protein search for iBlast/iMMSeqs2/iDiamond [PDF]

PeerJ
Background The advancement of sequencing technology has led to a rapid increase in the amount of DNA and protein sequence data; consequently, the size of genomic and proteomic databases is constantly growing.
Hyunwoo Yoo, Mohammadsaleh Refahi, Robi Polikar, Bahrad A. Sokhansanj, James R. Brown, Gail L. Rosen   +5 more
doaj   +2 more sources

Computational curation and analysis of publicly available protein sequence data from a single protein family

MethodsX, 2022
The wealth of sequence data available on public databases is increasing at an exponential rate, and while tremendous efforts are being made to make access to these resources easier, these data can be challenging for researchers to reuse because ...
Kyra Dougherty, Katalin A. Hudak
doaj   +1 more source

Predicting diverse M-best protein contact maps

, 2015
Protein contacts contain important information for protein structure and functional study, but contact prediction from sequence information remains very challenging.
Ma, Jianzhu, Sun, Siqi, Wang, Sheng, Xu, Jinbo   +3 more
core   +1 more source

AlignScape, displaying sequence similarity using self-organizing maps

Frontiers in Bioinformatics
The current richness of sequence data needs efficient methodologies to display and analyze the complexity of the information in a compact and readable manner.
Isaac Filella-Merce, Isaac Filella-Merce, Vincent Mallet, Eric Durand, Michael Nilges, Guillaume Bouvier, Riccardo Pellarin, Riccardo Pellarin   +7 more
doaj   +1 more source