Results 181 to 190 of about 3,931,468 (303)

The very early evolution of protein translocation across membranes. [PDF]

PLoS Comput Biol, 2021
Harris AJ, Goldman AD.
europepmc   +1 more source

Mitochondria‐Targeted Nanotherapies in Aging Neurodegenerative Disorders: Emerging Prospects and Clinical Potential

Advanced Healthcare Materials, EarlyView.
Mitochondria‐targeted nanotherapies emerge as a promising strategy for combating aging‐associated neurodegenerative disorders (NDs) by restoring mitochondrial function, reducing oxidative stress, and improving neuronal survival. Recent advances in nanotechnology, therapeutic delivery, and translational research are highlighted, providing insights into ...
Dnyandev G. Gadhave, Ashish B. Jadhav, Nitin B. Waghamode, Shubham Khot, Rajiya Khan, Ravi Hole, Shankar M. Dhobale, Manoj Aswar, Keshav Raj Paudel   +8 more
wiley   +1 more source

Ammonia induces amyloidogenesis in astrocytes by promoting amyloid precursor protein translocation into the endoplasmic reticulum. [PDF]

J Biol Chem, 2022
Komatsu A, Iida I, Nasu Y, Ito G, Harada F, Kishikawa S, Moss SJ, Maeda T, Terunuma M.   +8 more
europepmc   +1 more source

From Cell‐Derived Vesicles to Hybrid Nanovectors: Biological Membranes as Functional Blueprints for Gene Delivery

Advanced Healthcare Materials, EarlyView.
Biologically derived and hybrid nonviral nanovectors are examined as distinct but convergent design approaches. Integrating synthetic components with biologically functionalized membranes allows efficient interactions with complex cellular environments.
Clara Baldari, Claudia Leone, Gabriella Leccese, Claudia De Stradis, Alessandra Invidia, Concetta Quintarelli, Biagio De Angelis, Franco Locatelli, Giuseppe Gigli, Gabriele Maiorano, Ilaria Elena Palamà   +10 more
wiley   +1 more source

The mechanism of Tat-dependent protein translocation. [PDF]

Microb Cell
Brüser T, Sanders C.
europepmc   +1 more source

Optical Detection of Cellular Signals at Material Interfaces

Advanced Healthcare Materials, EarlyView.
Emerging functional materials are transforming optical detection of cellular signals. This review highlights optical techniques that exploit the unique optical properties of diverse materials to detect and quantify cellular electrical, chemical, and mechanical signals, and discusses key opportunities and challenges.
Xuchen Ren, Jitong Ren, Zixin Zhang, Koney Eungkon Kim, Francis L. Hong, Yuecheng Peter Zhou   +5 more
wiley   +1 more source

α-Synuclein blocks endoplasmic reticulum co-translational protein translocation early in Parkinson's disease. [PDF]

Nat Commun
Lam CL, Gatford NJF, Aragón-González A, Tanudjojo B, Sahoo A, Castle AR, Agarwal D, Jainarayanan A, Hester SS, Sen N, Benesch JLP, Fischer R, Sims D, Tofaris GK.   +13 more
europepmc   +1 more source

Influence of the TorD signal peptide chaperone on Tat-dependent protein translocation. [PDF]

PLoS One, 2021
Bageshwar UK, DattaGupta A, Musser SM.
europepmc   +1 more source

An Engineered Biomimetic Nanoreactor With Cascade Functions for Targeted and Combinatorial Therapy of Ischemic Stroke

Advanced Healthcare Materials, EarlyView.
Preparation of RVG‐modified erythrocyte membrane‐coated HMPB nanocarriers loaded with L‐arginine and NBP (RM@HPAN) and its neuroprotective mechanism. After intravenous injection, RM@HPAN achieves prolonged circulation, RVG‐29‐mediated BBB penetration, and ischemic accumulation.
Shaofa Li, Ying Wu, Huimin Wei, Jinyong Teng, Zaizhi Yang, Jufang Chen, Bao Liao, Xiaoqin Huang, Lanqing Meng, Tong Li   +9 more
wiley   +1 more source

Gated MoS₂/SiN nanochannel for tunable ion transport and protein translocation. [PDF]

J Nanobiotechnology
Weng S, Douaki A, Tsutsui M, Lanzavecchia G, Sapunova A, Iannetti L, Giacomello A, Krahne R, Garoli D.   +8 more
europepmc   +1 more source