Results 301 to 310 of about 6,532,398 (348)

Protein translocation into mitochondria

BioFactors, 1998
AbstractThe mitochondrial membranes contain translocation machineries (“preprotein translocases”) which facilitate transport of proteins from the cytosol into the mitochondria. The TOM complex is localized in the outer membrane. Two translocases have been characterized in the inner membrane: the Tim23‐Tim17 complex and
K, Káldi, W, Neupert
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Hsp70 proteins in protein translocation

2001
Publisher Summary Hsp70 proteins are essential components of the protein translocation systems of the endoplasmic reticulum (ER) and mitochondria. The role of Hsp70s in protein translocation is not confined to the ER and mitochondria. For most proteins of the ER, translocation is coupled with protein synthesis.
Ryan, Michael T., Pfanner, Nikolaus
openaire   +3 more sources

Protein translocation in apoptosis

Trends in Cell Biology, 1999
In programmed cell death (apoptosis), receptor-generated or other signals are transmitted to all cellular compartments, resulting in an apoptotic cell with extensive cytoplasmic and nuclear alterations. Protein translocation is now recognized as being crucial in the induction, amplification and regulation of this process.
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Thermodynamics of the Protein Translocation

2009
Many proteins synthesized in bacteria are secreted from the cytoplasm into the periplasm to function in the cell envelope or in the extracellular medium. The Sec translocase is a primary and evolutionary conserved secretion pathway in bacteria. It catalyzes the translocation of unfolded proteins across the cytoplasmic membrane via the pore-forming ...
Kedrov, A., den Blaauwen, T., Driessen, A.J.M.   +2 more
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Protein Translocation Across Biological Membranes

Science, 2005
Subcellular compartments have unique protein compositions, yet protein synthesis only occurs in the cytosol and in mitochondria and chloroplasts. How do proteins get where they need to go? The first steps are targeting to an organelle and efficient translocation across its limiting membrane.
William, Wickner, Randy, Schekman
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Translocator protein: pharmacology and steroidogenesis

Biochemical Society Transactions, 2015
The translocator protein (TSPO; 18k Da) is an evolutionarily conserved outer mitochondrial membrane (OMM) protein highly expressed in steroid-synthesizing cells and found to possess a number of physiological and drug-binding partners. Extensive pharmacological, biochemical and cell biological research over the years has led to a model of TSPO ...
Andrew, Midzak, Barry, Zirkin, Vassilios, Papadopoulos   +2 more
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Jamming Protein Translocation

Science Signaling, 2009
Antibiotics promote the destruction of a vital protein translocation complex in bacteria.
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The Sec protein-translocation pathway

Trends in Microbiology, 2001
The Sec machinery (or translocase) provides a major pathway of protein translocation from the cytosol across the cytoplasmic membrane in bacteria. The SecA ATPase interacts dynamically with the SecYEG integral membrane components to drive the transmembrane movement of newly synthesized preproteins.
H, Mori, K, Ito
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Bacterial Protein Translocation

1988
Protein translocation is a process common to all cells. Both prokaryotes and eukaryotes are divided into distinct compartments, each containing a unique set of proteins important to specific cellular functions. Except for a few mitochondrial and chloroplast proteins, almost all proteins are synthesized in the cytoplasm; therefore many proteins must ...
Elliott Crooke, William Wickner
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Translocation of Proteins into Mitochondria

Annual Review of Biochemistry, 2007
About 10% to 15% of the nuclear genes of eukaryotic organisms encode mitochondrial proteins. These proteins are synthesized in the cytosol and recognized by receptors on the surface of mitochondria. Translocases in the outer and inner membrane of mitochondria mediate the import and intramitochondrial sorting of these proteins; ATP and the membrane ...
Walter, Neupert, Johannes M, Herrmann
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