Results 51 to 60 of about 16,522,946 (324)

The Proteolytic Activity of Neutrophil-Derived Serine Proteases Bound to the Cell Surface Arming Lung Epithelial Cells for Viral Defense

Molecules
The collaboration between cellular proteases and host cells is pivotal in mounting an effective innate immune defense. Of particular interest is the synergistic interaction between cathepsin G (CatG) and neutrophil elastase (NE), which are proteases ...
Akmaral Assylbekova, Maiya Allayarova, Moldir Konysbekova, Amanbek Bekturgan, Aiya Makhanova, Samantha Brown, Norbert Grzegorzek, Hubert Kalbacher, Ruslan Kalendar, Timo Burster   +9 more
doaj   +1 more source

Proteinase 3 on apoptotic cells disrupts immune silencing in autoimmune vasculitis.

Journal of Clinical Investigation, 2015
Granulomatosis with polyangiitis (GPA) is a systemic necrotizing vasculitis that is associated with granulomatous inflammation and the presence of anti-neutrophil cytoplasmic antibodies (ANCAs) directed against proteinase 3 (PR3).
A. Millet, Katherine R. Martin, F. Bonnefoy, P. Saas, Julie Mocek, M. Alkan, B. Terrier, A. Kerstein, NICOLA TAMASSIA, S. K. Satyanarayanan, A. Ariel, J. Ribeil, L. Guillevin, M. Cassatella, A. Mueller, N. Thieblemont, P. Lamprecht, L. Mouthon, S. Perruche, V. Witko-Sarsat   +19 more
semanticscholar   +1 more source

Circulating ADAM17 Level Reflects Disease Activity in Proteinase-3 ANCA-Associated Vasculitis.

Journal of the American Society of Nephrology, 2015
ANCA-associated vasculitides are characterized by inflammatory destruction of small vessels accompanied by enhanced cleavage of membrane-bound proteins.
Anna Bertram, S. Lovric, Alissa Engel, Michaela Beese, K. Wyss, B. Hertel, Joon-Keun Park, J. Becker, Johanna Kegel, H. Haller, M. Haubitz, T. Kirsch   +11 more
semanticscholar   +1 more source

Proteinase 3 and prognosis of patients with acute myocardial infarction [PDF]

Clinical Science, 2010
A multimarker approach may be useful for risk stratification in AMI (acute myocardial infarction) patients, particularly utilizing pathways that are pathophysiologically distinct. Our aim was to assess the prognostic value of PR3 (proteinase 3) in patients post-AMI.
Ng, Leong L., Khan, Sohail Q., Narayan, Hafid, Quinn, Paulene, Squire, Iain B., Davies, Joan E.   +5 more
openaire   +4 more sources

Interaction vesicles as emerging mediators of host‐pathogen molecular crosstalk and their implications for infection dynamics

FEBS Letters, EarlyView.
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke, Izadora Volpato Rossi, Marcel I. Ramirez   +2 more
wiley   +1 more source

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

Protonophore activity of short‐chain fatty acids induces their intracellular accumulation and acidification

FEBS Letters, EarlyView.
The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang, Frans Bianchi, Geert van den Bogaart   +2 more
wiley   +1 more source

Performance of two multiplex flow cytometric assays for antibody detection in Egyptian patients

African Journal of Laboratory Medicine, 2023
Background: Autoantibodies are vital biomarkers for the diagnosis, assessment and prognostic determination of various autoimmune disorders. Objective: This study aimed to evaluate the performance of the two AtheNA Multi-Lyte® systems for the detection ...
Alshymaa A. Ahmed, Alia A. El Shahaway, Heba M. Kadry, Nora M. Said   +3 more
doaj   +1 more source

The thioredoxin‐like and one glutaredoxin domain are required to rescue the iron‐starvation phenotype of HeLa GLRX3 knock out cells

FEBS Letters, EarlyView.
Glutaredoxin (Grx) 3 proteins contain a thioredoxin domain and one to three class II Grx domains. These proteins play a crucial role in iron homeostasis in eukaryotic cells. In human Grx3, at least one of the two Grx domains, together with the thioredoxin domain, is essential for its function in iron metabolism.
Laura Magdalena Jordt, Manuela Gellert, Finja Zelms, Sander Bekeschus, Christopher Horst Lillig   +4 more
wiley   +1 more source

S100A12 Serum Levels and PMN Counts Are Elevated in Childhood Systemic Vasculitides Especially Involving Proteinase 3 Specific Anti-neutrophil Cytoplasmic Antibodies

Frontiers in Pediatrics, 2018
Objectives: Chronic primary systemic vasculitidies (CPV) are a collection of rare diseases involving inflammation in blood vessels, often in multiple organs. CPV can affect adults and children and may be life- or organ-threatening.
Kelly L. Brown, Kelly L. Brown, Joanna M. Lubieniecka, Giulia Armaroli, Katharina Kessel, Kristen M. Gibson, Kristen M. Gibson, Jinko Graham, Dongmeng Liu, Robert E. W. Hancock, Robert E. W. Hancock, Colin J. Ross, Colin J. Ross, Susanne M. Benseler, Raashid A. Luqmani, David A. Cabral, David A. Cabral, Dirk Foell, Christoph Kessel   +18 more
doaj   +1 more source