Results 61 to 70 of about 409,825 (329)
Performance of two multiplex flow cytometric assays for antibody detection in Egyptian patients
African Journal of Laboratory Medicine, 2023 Background: Autoantibodies are vital biomarkers for the diagnosis, assessment and prognostic determination of various autoimmune disorders. Objective: This study aimed to evaluate the performance of the two AtheNA Multi-Lyte® systems for the detection ...
Alshymaa A. Ahmed +3 more
doaj +1 more source
Role of saliva proteinase 3 in dental caries [PDF]
International Journal of Oral Science, 2015 Salivary analysis can be used to assess the severity of caries. Of the known salivary proteins, a paucity of information exists concerning the role of proteinase 3 (PR3), a serine protease of the chymotrypsin family, in dental caries. Whole, unstimulated saliva was collected from children with varying degrees of active caries and tested using a Human ...
Yang, Teng-Yu +14 more
openaire +2 more sources
How endo- is endo-?: surface sterilization of delicate samples: a Bryopsis (Bryopsidales, Chlorophyta) case study [PDF]
, 2010 In the search for endosymbiotic bacteria, elimination of ectosymbionts is a key point of attention. Commonly, the surface of the host itself or the symbiotic structures are sterilized with aggressive substances such as chlorine or mercury derivatives ...
De Clerck, Olivier +3 more
core +2 more sources
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
Proteinase 3 is an IL-32 binding protein [PDF]
Proceedings of the National Academy of Sciences, 2006 IL-32, a recently discovered proinflammatory cytokine with four isoforms, induces IL-1β, TNF-α, IL-6, and chemokines. Here, we used ligand (IL-32α) affinity chromatography in an attempt to isolate an IL-32α soluble receptor or binding protein. Recombinant IL-32α was covalently immobilized on agarose, and preparations of concentrated crude human urinary
Daniela, Novick +5 more
openaire +2 more sources
Regulation of elastase and plasminogen activator secretion in resident and inflammatory macrophages by receptors for the Fc domain of immunoglobulin G. [PDF]
, 1984 We have determined that the interaction of IgG-coated erythrocytes (EIgG) and complement-coated erythrocytes (EIgMC) with macrophage Fc and complement receptors, respectively, modulates the secretion of the neutral proteinases, elastase, and plasminogen ...
Takemura, R, Werb, Z
core
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
Cytotoxicity of the Bacillus thuringiensis Crystal Protein against Mammalian Cells [PDF]
, 2002 The crystal proteins produced by Bacillus thuringiensis subsp, israelensis (Bti) and subsp. coreanensis A1519 strain were examined for the cytotoxicity against MOLT-4 and HeLa cells by MTT assay and LDH assay, The A1519 crystal proteins processed by ...
Akao, Tetsuyuki +5 more
core +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Substrate and inhibitor studies on proteinase 3
FEBS Letters, 1992 Various amino acid and peptide thioesters were tested as substrates for human proteinase 3 and the best substrate is Boc‐Ala‐Ala‐Nva‐SBzl with a k cal/K m value of 1.0 × 106nMit‐1sit‐1 Boc‐Ala‐Ala‐AA‐SBzl (AA = Val, Ala, or Met) are also good substrates with k cal/K m values of (1‐4) × 105 M−1 s−1.
Kam, C. M. +5 more
openaire +2 more sources