Results 71 to 80 of about 16,522,946 (324)

Neutrophil Elastase and Proteinase-3 Trigger G Protein-biased Signaling through Proteinase-activated Receptor-1 (PAR1)*

Journal of Biological Chemistry, 2013
Background: Proteinase-activated receptor-1 (PAR1) is a proteolytically activated G protein-coupled receptor. Neutrophil-derived enzymes might regulate PAR1 signaling.
K. Mihara, R. Ramachandran, B. Renaux, M. Saifeddine, M. Hollenberg   +4 more
semanticscholar   +1 more source

Anti-proteinase 3 antibodies, their characterization and disease associations [PDF]

Clinical and Experimental Immunology, 1994
SUMMARY Anti-proteinase 3 antibodies are a subgroup of anti-neutrophil cytoplasmic antibodies (ANCA), and we have established an ELISA for their detection using high performance liquid chromatograhy (HPLC)-purified protein. This assay is sensitive and specific: inhibition studies have shown that despite the homology between proteinase 3 ...
J G Jennings, L Chang, Judy Savige
openaire   +3 more sources

Goodbye flat lymphoma biology

FEBS Letters, EarlyView.
Three‐dimensional (3D) biological systems have become key tools in lymphoma research, offering reliable in vitro and ex vivo platforms to explore pathogenesis and support precision medicine. This review highlights current 3D non‐Hodgkin lymphoma models, detailing their features, advantages, and limitations, and provides a broad perspective on future ...
Carla Faria, Cèlia Dobaño‐López, Patricia Pérez‐Galán, Christine Bezombes   +3 more
wiley   +1 more source

Antineutrophil cytoplasmic antibody profiles differ according to type of primary sclerosing cholangitis and autoimmune hepatitis [PDF]

Clinics
OBJECTIVES: To determine the frequency of the antineutrophil cytoplasmic antibodies (ANCA), antiproteinase-3 and antimyeloperoxidase, in primary sclerosing cholangitis (PSC) with or without inflammatory bowel disease (IBD+ or IBD-) and in different types
Juliana Goldbaum Crescente, Alessandra Dellavance, Marcio Augusto Diniz, Flair Jose Carrilho, Luis Eduardo Coelho de Andrade, Eduardo Luiz Rachid Cançado   +5 more
doaj   +2 more sources

Enzymatic treatment of specimens before DNA extraction directly influences molecular detection of infectious agents. [PDF]

PLoS ONE, 2014
INTRODUCTION: Biological samples, pharmaceuticals or food contain proteins, lipids, polymers, ammoniums and macromolecules that alter the detection of infectious agents by DNA amplification techniques (PCR).
Pablo Goldschmidt, Sandrine Degorge, Lilia Merabet, Christine Chaumeil   +3 more
doaj   +1 more source

The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1

FEBS Letters, EarlyView.
MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson, Robert Gustafsson Westergren, Ingrid Almlöf, Ann‐Sofie Jemth, Martin Scobie, Ulrika Warpman Berglund, Thomas Helleday, Pål Stenmark   +7 more
wiley   +1 more source

FRI0164 Antibodies to proteinase-3, myeloperoxidase and b2gpi [PDF]

Annals of the Rheumatic Diseases, 2001
Background Objectives To investigate the relationship between antibodies to proteinase-3 (anti-PR3), myeloperoxidase (anti-MPO) and b2GPI (anti-b2GPI) in patients (pts) with systemic vasculitis and primary antiphospholipid syndrome (PAPS). Methods The sera from 18 pts with polyarteritis nodosa (PAN), 18 pts with Takayasu’s arteritis (TA), 21 pts ...
TV Beketova, OV Bashina, Baranov Aa, SY Kirdyanov, Gurieva, NE Abaytova, EL Nassonov   +6 more
openaire   +2 more sources

Mycobacterium tuberculosis sulfurtransferase SseA is activated by its neighboring gene product Rv3284

FEBS Letters, EarlyView.
Tuberculosis remains a global health challenge and new therapeutic targets are required. Here, we characterized SseA, a sulfurtransferase from Mycobacterium tuberculosis involved in macrophage infection, and its interaction with the newly identified protein SufEMtb that activates SseA enzymatic activity.
Giulia Di Napoli, Alex Fissore, Edoardo Salladini, Eleonora Raccuia, Simonetta Oliaro‐Bosso, Alessia Ruggiero, Rita Berisio, Milagros Medina, Adrian Velazquez‐Campoy, Salvatore Adinolfi, Mauro Marengo   +10 more
wiley   +1 more source

Crystallization of the bifunctional proteinase/amylase inhibitor PKI‐3 and of its complex with proteinase K

FEBS Letters, 1986
One of the three wheat germ inhibitors of proteinase K is bifunctional and inhibits simultaneously proteinase K (or subtilisin but not enzymes of the trypsin family) and insect α‐amylase. The molecular mass of this inhibitor called PKI‐3 is 21 kDa, and the binding constant for proteinase K is 0.8 nM at pH 8.2, 25°C, in 1:1 molar ratio.
Klaus-Dieter Jany, Wolfram Saenger, Gour P. Pal, Christian Betzel   +3 more
openaire   +3 more sources

Aβ42 promotes the aggregation of α‐synuclein splice isoforms via heterogeneous nucleation

FEBS Letters, EarlyView.
The aggregation of amyloid‐β (Aβ) and α‐synuclein (αSyn) is associated with Alzheimer's and Parkinson's diseases. This study reveals that Aβ aggregates serve as potent nucleation sites for the aggregation of αSyn and its splice isoforms, shedding light on the intricate interplay between these two pathogenic proteins.
Alexander Röntgen, Zenon Toprakcioglu, Michele Vendruscolo   +2 more
wiley   +1 more source