Results 191 to 200 of about 109,553 (241)

A Darwinian approach to the development of the vascular system in the vertebrates. [PDF]

Clin Exp Med
Ribatti D.
europepmc   +1 more source

Disease Progression Mathematical Modeling With a Case Study on Hepatitis B Virus Infection

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 420-434, March 2025.
ABSTRACT Chronic Hepatitis B presents a significant health and socioeconomic burden. The risk of hepatocellular carcinoma remains elevated although treatments are available. Achieving an optimal treatment regimen necessitates a deep comprehension of the dynamic relationship between the virus and its host across disease states.
Clémence Boivin‐Champeaux, Nieves Velez de Mendizabal, Aksana Jones, Scott Balsitis, Stephan Schmidt, Justin S. Feigelman, Francine Johansson Azeredo   +6 more
wiley   +1 more source

Soluble Proteoglycans and Proteoglycan Fragments as Biomarkers of Pathological Extracellular Matrix Remodeling. [PDF]

Proteoglycan Res
Kemberi M, Minns AF, Santamaria S.
europepmc   +1 more source

Native and Engineered Extracellular Vesicles for the Treatment of Acute Lung Injury and Acute Respiratory Distress Syndrome

Small Science, EarlyView.
Both native and engineered extracellular vesicles (EVs) are served as promising therapeutic agents for treating acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). To circumvent the limitations of native EVs, various engineering strategies are adopted.
Zhengyan Gu, Wenjun Xue, Guanchao Mao, Zhipeng Pei, Jingjing Li, Mingxue Sun, Xinkang Zhang, Shanshan Zhang, Songling Li, Jinfeng Cen, Kai Xiao, Ying Lu, Qingqiang Xu   +12 more
wiley   +1 more source

Development of the mechanoresponsive pericellular matrix of chondrons. [PDF]

Sci Adv
Lee D, Greer SE, Dudley AT.
europepmc   +1 more source

Single Extracellular Vesicle Profiling to Define Brain Specific Traumatic Brain Injury Induced Neuro‐Inflammation

Small Methods, EarlyView.
A highly innovative and implementable diagnostic tool for profiling microenvironmental perturbations in TBI patients by analyzing sEVs derived from glial cells circulating in the blood. This device provides a window into the injured brain and identifies neuroinflammatory signals, potentially serving as a platform for detecting highly specific brain ...
Zhen Zhang, Richard J Lobb, Rebecca E Lane, Xuan Vinh To, Xueming Niu, Fiach Antaw, Giovanni Pietrogrande, Craig Winter, Alain Wuethrich, Fatima Nasrallah, Matt Trau   +10 more
wiley   +1 more source

Biomimetic Proteoglycans for Intervertebral Disc (IVD) Regeneration. [PDF]

Biomimetics (Basel)
Chopra N, Melrose J, Gu Z, Diwan AD.
europepmc   +1 more source

Kartogenin‐Loaded Aminated Hollow Mesoporous Prussian Blue Nanozyme‐Reinforced Hydrogel Remodels the Senescent Microenvironment via Reactive Oxygen Species Scavenging and Stimulator of Interferon Genes Inhibition to Promote Cartilage Regeneration

Small Structures, EarlyView.
This study successfully develops an injectable, dual‐function nanocomposite hydrogel comprising kartogenin‐loaded aminated hollow mesoporous Prussian blue (NH2‐HMPB) nanozyme (termed NH@K nanozyme) and hyaluronic acid methacrylate (HAMA). NH@K nanozyme rejuvenates the senescent microenvironment by scavenging reactive oxygen species and inhibiting ...
Shu‐Hang He, Zhi‐Han Shen, Ren Zhang, Po‐Lin Liu, Xu‐Ran Li, Qing‐Song Deng, Yu‐Chen Zhang, Ang Wang, Xiao‐Qiu Dou, Shang‐Chun Guo, Shi‐Cong Tao   +10 more
wiley   +1 more source

Plasma POSTN Derived From Bile Proteome Is a Promising Biomarker for Cholangiocarcinoma With Efficacy Comparable and Complementary to CA19.9

United European Gastroenterology Journal, EarlyView.
ABSTRACT Background Cholangiocarcinoma presents a global health challenge due to its increasing incidence and poor prognosis, primarily resulting from delayed diagnosis. There is an urgent need for a reliable biomarker to enhance early detection. Materials and Methods Patients with cholangiocarcinoma were enrolled into three cohorts: a discovery set (n 
Lichieh Julie Chu, Chia‐Jung Tsai, Chun‐Chun Chien, Yung‐Chin Hsiao, Jau‐Song Yu, Jun‐Yi Tsai, Ta‐Sen Yeh   +6 more
wiley   +1 more source

A new ex vivo human model of osteoarthritis cartilage calcification. [PDF]

Rheumatology (Oxford)
Faure E, Wegrzyn J, Bernabei I, Falgayrac G, Bertheaume N, Pascart T, Hugle T, Busso N, Nasi S.   +8 more
europepmc   +1 more source