Results 101 to 110 of about 56,365 (241)

Proteostasis During Cerebral Ischemia

Frontiers in Neuroscience, 2019
Cerebral ischemia is a complex pathology involving a cascade of cellular mechanisms, which deregulate proteostasis and lead to neuronal death. Proteostasis refers to the equilibrium between protein synthesis, folding, transport, and protein degradation ...
Audrey M. Thiebaut, Elodie Hedou, Stefan J. Marciniak, Stefan J. Marciniak, Denis Vivien, Denis Vivien, Benoit D. Roussel   +6 more
doaj   +1 more source

Regulation of cell-­nonautonomous proteostasis in metazoans [PDF]

, 2016
Cells have developed robust adaptation mechanisms to survive environmental conditions that challenge the integrity of their proteome and ensure cellular viability.
O'Brien, D, Van Oosten-Hawle, PC
core   +1 more source

Repeated Disuse Atrophy Imprints a Molecular Memory in Skeletal Muscle: Transcriptional Resilience in Young Adults and Susceptibility in Aged Muscle

Advanced Science, EarlyView.
Repeated disuse imprints a molecular memory in skeletal muscle, conferring transcriptional resilience in young adults but exaggerated susceptibility in aged muscle, driven by epigenetic regulation of aerobic metabolism, mitochondrial and NAD+ pathways.
Daniel C. Turner, Truls Raastad, Max Ullrich, Stian F. Christiansen, Hazel Sutherland, James Boot, Eva Wozniak, Charles Mein, Emilie Dalbram, Jonas T. Treebak, Daniel J. Owens, David C. Hughes, Sue C. Bodine, Jonathan C. Jarvis, Adam P. Sharples   +14 more
wiley   +1 more source

Repair or destruction: an intimate liaison between ubiquitin ligases and molecular chaperones in proteostasis [PDF]

, 2017
Cellular differentiation, developmental processes, and environmental factors challenge the integrity of the proteome in every eukaryotic cell. The maintenance of protein homeostasis, or proteostasis, involves folding and degradation of damaged proteins ...
Amerik, Anckar, Apaja, Arndt, Arndt, Aviram, Balch, Ballinger, Bar-Lavan, Barrott, Bartel, Bays, Becuwe, Behrends, Bengtson, Boban, Boban, Bodnar, Boomsma, Bordallo, Brandman, Brehme, Broersen, Buchner, Calderwood, Carra, Catlett, Choe, Christianson, Chu, Ciechanover, Ciocca, Ciryam, Commerford, Connell, Craig, Crippa, Crosas, Cuervo, Cuervo, Cyr, Dai, Davies, Defenouillere, Deng, Deyter, Donati, Douglas, Douglas, Dunker, Duttler, Ehrlich, Eisele, Ellis, Fan, Fang, Fang, Fang, Fang, Ferreira, Finley, Finley, Foresti, Fourie, Fredrickson, Gallagher, Gamerdinger, Gardner, Garrido, Goldberg, Guerriero, Guo, Han, Hartl, Hatakeyama, Heck, Hemmingsen, Hessa, Hettema, Higy, Hondele, Hondele, Hoppe, Iwata, Jana, Jego, Jiang, Jin, Joshi, Kahn, Kampinga, Kaplan, Katsogiannou, Kaushik, Kaushik, Keller, Kenyon, Kerscher, Kettern, Khmelinskii, Kim, Kitagawa, Koegl, Komander, Koren, Kraft, Kuhlbrodt, Kuhlbrodt, Kumar, Kuo, Kwon, Laba, Labbadia, Lakshmipathy, Lee, Lerch-Bader, Levine, Li, Li, Lopez, Lopez-Otin, MacGurn, Maier, Matsumura, Mattiroli, Maurer, McDonough, Meacham, Mehnert, Meng, Merz, Metzger, Min, Mishra, Mizushima, Morano, Morimoto, Morimoto, Morimoto, Morishima, Murata, Murata, Nahleh, Nillegoda, Nillegoda, Nillegoda, Park, Park, Paul, Petrucelli, Powers, Powers, Prasad, Qian, Ranford, Rape, Ravid, Rees, Roberts, Roberts, Rodina, Rodrigo-Brenni, Rosenbaum, Ruggiano, Russell, Rüb, Rüdiger, Saez, Saibil, Salminen, Samant, Schopf, Shahsavarani, Shao, Shiber, Shiga, Shin, Singh, Singh, Singh, Soss, Sowa, Spiechowicz, Stuttmann, Sulistio, Sultana, Summers, Sung, Swanson, Taipale, Takayama, Tasaki, Tasaki, Tawo, Taylor, Terman, Tzankov, Ulbricht, Urushitani, VanPelt, Venkatesh, Verma, Vilchez, Walther Dirk, Wang, Wang, Willhoft, Williams, Xie, Xu, Xu, Yonashiro, Yu, Zargari, Zhang, Zhang, Zhao, Zhao, Zhou, Zuehlke, Zuiderweg   +220 more
core   +1 more source

PAIR: Reconstructing Single‐Cell Open‐Chromatin Landscapes for Transcription Factor Regulome Mapping

Advanced Science, EarlyView.
scATAC‐seq analysis is often constrained by limited sequencing depth, extreme sparsity, and pervasive technical missingness. PAIR is a probabilistic framework that restores scATAC‐seq accessibility profiles by directly modeling the native cell–peak bipartite structure of chromatin accessibility.
Yanchi Su, Qi Qi, Yi Fan, Yubo Wang, Gaoyang Hao, Ka‐Chun Wong, Yunhe Wang, Xiangtao Li   +7 more
wiley   +1 more source

Proteostasis in Cerebral Small Vessel Disease

Frontiers in Neuroscience, 2019
Maintaining the homeostasis of proteins (proteostasis) by controlling their synthesis, folding and degradation is a central task of cells and tissues. The gradual decline of the capacity of the various proteostasis machineries, frequently in combination ...
Christof Haffner
doaj   +1 more source

Quantitating the epigenetic transformation contributing to cholesterol homeostasis using Gaussian process. [PDF]

, 2019
To understand the impact of epigenetics on human misfolding disease, we apply Gaussian-process regression (GPR) based machine learning (ML) (GPR-ML) through variation spatial profiling (VSP). VSP generates population-based matrices describing the spatial
Balch, William E, Farhat, Nicole Y, Hutt, Darren M, Loguercio, Salvatore, Porter, Forbes D, Scott, Samantha M, Subramanian, Kanagaraj, Wang, Chao, Zhao, Pei   +8 more
core   +1 more source

Cotranslational folding of proteins on the ribosome.

, 2020
Many proteins in the cell fold cotranslationally within the restricted space of the polypeptide exit tunnel or at the surface of the ribosome. A growing body of evidence suggests that the ribosome can alter the folding trajectory in many different ways ...
Liutkute, M., Rodnina, M., Samatova, E.
core   +1 more source

Lifespan extension in Caenorhabditis elegans insulin/IGF-1 signalling mutants is supported by non-vertebrate physiological traits [PDF]

, 2017
The insulin/IGF-1 signalling (IIS) pathway connects nutrient levels to metabolism, growth and lifespan in eukaryotes ranging from yeasts to humans, including nematodes such as the genetic model organism Caenorhabditis elegans. The link between ageing and
Braeckman, Bart, Dhondt, Ineke
core   +2 more sources

A Novel GmSIN1‐GmRNF1a‐GmCSN5a Module Determines Soybean Salt Tolerance and Yield Under Saline Soil Conditions

Advanced Science, EarlyView.
Soybean production is severely threatened by salt stress. This study reveals that the GmSIN1‐GmRNF1a‐GmCSN5a module enhances salt tolerance by stabilizing the GmSIN1 protein. GmRNF1a acts as an E3 ligase to ubiquitinate GmSIN1 for degradation, a process inhibited by GmCSN5a.
Jinlong Xu, Mengqi Shan, Xinxin Yang, Rongmei Zhao, Mengke Zhang, Guohua Bao, Lili Wang, Mingru Li, Wenjiao Zhi, Muzi Wang, Tianshi Liu, Xiaojian Zheng, Wenyu Zheng, Qing Lu, Shuo Li, Fengning Xiang   +15 more
wiley   +1 more source