Results 121 to 130 of about 62,588 (334)
Healthy ageing through regulated proteostasis [PDF]
The EMBO Journal, 2011 During metazoan life, protein homeostasis (proteostasis) declines with age due to impaired proteasome activity. The signalling pathways activated by growth factors that regulate proteostasis and their importance to ageing are just emerging. In this issue, Liu et al report a crucial role of epidermal growth factor (EGF) in regulating Caenorhabditis ...Krishnaraj, Rajalingam, Ivan, Dikicopenaire +2 more sourcesHSP70 Interactome‐Mediated Proteolysis Targeting Chimera (HSP70‐PROTAC) for Ferroptosis‐Driven Cancer Treatment
Advanced Science, EarlyView.This study reports a novel targeted protein degradation strategy termed “HSP70‐PROTAC” that recruits Hsc70 complex to a target protein for inducing degradation. Among them, GDAz‐3 exhibits effective GPX4 degradation activity via UPS/CMA processes, triggering ferroptosis‐driven anticancer activity in vitro and in vivo.Jinyun Dong, Yulong Li, Hui Liang, Zumei Wu, Shiqun Wang, Yichao Wang, Jieyu Xu, Yanning Lan, Maohua Cai, Guangzhao Pan, Haiyan Yang, Kai Miao, Zhe‐Sheng Chen, Fangfang Tao, Xuelei Ma, Jiang‐Jiang Qin +15 morewiley +1 more sourceProteostasis Dysregulation in Pancreatic Cancer [PDF]
, 2020 The most common form of pancreatic cancer, pancreatic ductal adenocarcinoma (PDAC), has a dismal 5-year survival rate of less than 5%. Radical surgical resection, in combination with adjuvant chemotherapy, provides the best option for long-term patient survival. However, only approximately 20% of patients are resectable at the time of diagnosis, due to Arpalahti, Leena, Haglund, Caj, Holmberg, Carina I +2 moreopenaire +3 more sourcesEngineered GM1 Intersects Between Mitochondrial and Synaptic Pathways to Ameliorate ALS Pathology
Advanced Science, EarlyView.Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease driven by genetic and molecular disruptions affecting energy balance, protein homeostasis, and stress responses in nerve cells. Studies using human and rodent models identified convergent defects in mitochondria and synaptic function.Federica Pilotto, Tristan Dellazizzo Toth, Silvano Bond, Alexander Schmitz, Rim Diab, Sara Y. Ngo Tenlep, Brian Mooney, Silvia Erni, Martina Schobesberger, Olivier Scheidegger, Camille Peitsch, Smita Saxena +11 morewiley +1 more sourceProteostasis in pediatric pulmonary pathology [PDF]
Molecular and Cellular Pediatrics, 2014 Protein homeostasis describes the tight supervision of protein synthesis, correct protein maturation and folding, as well as the timely disposal of unwanted and damaged proteins by the ubiquitin-proteasome pathway or the lysosome-autophagy route. The cellular processes involved in preservation of protein homeostasis are collectively called proteostasis.Meiners, S., Ballweg, K.openaire +3 more sourcesAutophagy Activators Normalize Aberrant Tau Proteostasis and Rescue Synapses in Human Familial Alzheimer's Disease iPSC‐Derived Cortical Organoids
Advanced Science, EarlyView.A new cerebrocortical organoid model using isogenic hiPSCs with familial Alzheimer's mutations recapitulates key AD features, including amyloid‐beta and phospho‐Tau aggregation, neuronal hyperexcitability, and synapse loss. Single‐cell RNA‐seq reveals aberrant pathways in excitatory and inhibitory neurons.Sergio R. Labra, Jadon Compher, Akhil Prabhavalkar, Mireya Almaraz, Claudia Cedeño Kwong, Christine Baal, Maria Talantova, Nima Dolatabadi, Julian Piña‐Sanz, Yubo Wang, Leonard Yoon, Swagata Ghatak, Zi Gao, Yuting Zhang, Dorit Trudler, Lynee Massey, Wei Lin, Anthony Balistreri, Michael Bula, Nicholas J. Schork, Tony S. Mondala, Steven R. Head, Jeffery W. Kelly, Stuart A. Lipton +23 morewiley +1 more sourceThe disruption of proteostasis in neurodegenerative diseases [PDF]
, 2015 Cells count on surveillance systems to monitor and protect the cellular proteome which, besides being highly heterogeneous, is constantly being challenged by intrinsic and environmental factors. 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Xie J, Tang L, Lu L, et al., Xu D, Zalmas LP, La Thangue NB, Xu Y, Cai M, Yang Y, et al., Xu Z, Horwich AL, Sigler PB, Yamamoto K, Sato T, Matsui T, et al., Ye J, Rawson RB, Komuro R, et al., Yoshida H, Matsui T, Yamamoto A, et al., Yoshida H, Oku M, Suzuki M, et al., Yoshida H, Uemura A, Mori K, Young JC, Barral JM, Ulrich Hartl F, Yu A, Shibata Y, Shah B, et al., Zhang Y, Lu H, Bargmann CI, Zhao Q, Wang J, Levichkin IV, et al., Zietkiewicz S, Lewandowska A, Stocki P, et al., Zolkiewski M, Zou J, Guo Y, Guettouche T, et al. +251 morecore +2 more sources
