Results 151 to 160 of about 56,365 (241)

Diabetes, hipoxia e doenças cardiovasculares: do mecanismo molecular ao tratamento

Revista Portuguesa de Cardiologia, 2017
João Vasco Ferreira
doaj   +1 more source

Synaptic Chaperone Dysfunction as a Convergent Mechanism in Neurodegenerative and Psychiatric Disorders. [PDF]

Neurosci Insights
Jean D, Li Y.
europepmc   +1 more source

A Lavandula angustifolia flower extract and dipeptide‐4 blend modulates oxidative, glycative, autophagic and circadian pathways in human skin models

International Journal of Cosmetic Science, EarlyView.
The blend enhanced antioxidation, anti‐glycation, autophagy and circadian regulation in cell and skin models. Key markers included mitochondrial ROS, γ‐H2AX, AGEs, ATP, melatonin, LC3 and SOD. Significant improvements were visualized via fluorescence and quantified with statistical markers.
Lina Wang, Yuxuan Wu, Huiping Hu, Yanan Li, Peiwen Sun   +4 more
wiley   +1 more source

The α-synuclein proteostasis network and its translational applications in Parkinson's disease. [PDF]

Proc Natl Acad Sci U S A
Lim CM, Vendruscolo M.
europepmc   +1 more source

Molecular Signatures of Peripheral and Central Dental Pulp Subpopulations in Response to Streptococcus mutans: A Bulk RNA‐Seq Analysis

International Endodontic Journal, EarlyView.
ABSTRACT Aim The dental pulp is an immunologically active tissue that responds dynamically to cariogenic challenge. Peripheral pulp cells adjacent to dentine encounter bacterial stimuli earlier than cells located in the central pulp. To investigate signalling and immune interactions, this study profiled the transcriptomes of dentine‐adherent cells ...
Sandra Pohl, Maximilian L. Huber, Tobias Akamp, Andreas Rosendahl, Melanie Linnebank, Lea Schreiber, Claudia Gebhard, Nicholas Strieder, Michael Rehli, Wolfgang Buchalla, Matthias Widbiller   +10 more
wiley   +1 more source

The endoplasmic reticulum in mitochondrial protein targeting: A neuronal perspective on organelle crosstalk. [PDF]

Protein Sci
Hees JT, Harbauer AB.
europepmc   +1 more source

Age‐related differences in mRNA vaccine immunogenicity and adjuvancy

Immunology &Cell Biology, EarlyView.
Older people often respond poorly to mRNA vaccines, with reduced T and B cell responses, but they also bear more morbidity and mortality for infectious diseases. This paper maps age‐related changes in mechanisms of adjuvancy that can shape the immunogenicity of mRNA vaccine in a mouse model. Created in BioRender.
Shivali Savita Chinni, Gemma S Trollope, Patrick Leung, Jonathan L McQualter, Chee Wah Tan, Linfa Wang, Leonard Lim, Adam K Wheatley, Jennifer A Juno, Stephen J Kent, Hareth A Al‐Wassiti, Colin W Pouton, Kylie M Quinn   +12 more
wiley   +1 more source

Heat shock proteins (Hsp70 and Hsp90) in neurodegeneration: pathogenic roles and therapeutic potential. [PDF]

Front Aging Neurosci
Ben Khalaf N.
europepmc   +1 more source

Role of the UHRF1–KLHL6–CORO2B axis in obesity‐related insulin resistance

Journal of Diabetes Investigation, EarlyView.
In high‐fat diet (HFD)‐induced obese mice with insulin resistance, overexpression of UHRF1 may recruit DNMT1 to promote DNA methylation of KLHL6, leading to its downregulation. Subsequently, suppression of KLHL6 may decrease the ubiquitination of CORO2B, resulting in elevated CORO2B protein levels.
Xu Deng, Xiaoping Li, Jialuo Cai, Xinyu Chen, Zelin Xu, Yuntao Luo   +5 more
wiley   +1 more source

Sarcosine is uniquely modulated by aging and dietary restriction in rodents and humans [PDF]

, 2018
et al,, Fontana, Luigi, Tosti, Valeria
core   +1 more source