Results 161 to 170 of about 48,911 (292)

Diabetes, hipoxia e doenças cardiovasculares: do mecanismo molecular ao tratamento

Revista Portuguesa de Cardiologia, 2017
João Vasco Ferreira
doaj   +1 more source

Exercise elicits mitonuclear protein imbalance and UPR^mt in the liver of mice with obesity. [PDF]

J Physiol Biochem
Rocha MB, de Araujo IM, Coleta SGDND, Junior SJA, Peres SF, Braga RR, Brícola RS, Carneiro FS, Crisol BM, da Costa RG, Mori MAS, Cintra DE, da Silva ASR, Pauli JR, Ropelle ER.   +14 more
europepmc   +1 more source

Proteostasis mechanics of neurodegenerative diseases

The main feature of many neurodegenerative diseases is inappropriate protein aggregation arising from protein homeostasis (proteostasis) imbalance. My vision is to capitalize on a suite of new methods I have established to determine how breakdown in ...

core  

Recent Advances in Top‐Down Proteomics for Single‐Cell Research

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Individual cells have distinctive molecular characteristics, including biologically relevant proteoforms. Although single‐cell (SC) molecular omics offer unprecedented insights into cellular heterogeneity and function, the characterization of proteoforms in SCs remains an uncharted territory.
Jake A. Melby, Pei Su, Fabio P. Gomes
wiley   +1 more source

Protein Homeostasis and Mitochondrial Quality Control in Neurodegeneration. [PDF]

WIREs Mech Dis
Di Lorenzo R, Zeidan RS, Calvani R, Pesce V, Marzetti E, Picca A.   +5 more
europepmc   +1 more source

Multiomics Insights Into AL Amyloidosis

Medicine Bulletin, EarlyView.
ABSTRACT Light chain amyloidosis is a systemic or localized protein conformational disorder triggered by misfolded immunoglobulin light chains, leading to amyloid fibril deposition. The disease is characterized by multiorgan involvement and delayed diagnosis, contributing to poor prognosis and high mortality rates.
Zixuan Zhang, Ziru Huang, Haoxiang Tang, Xianrun Pan, Rong Wang, Dingding Zhang, Jian Huang   +6 more
wiley   +1 more source

Reprogramming Mitochondrial Adaptation: LONP1 at the Crossroads of Proteostasis, Metabolism, and Disease. [PDF]

Antioxidants (Basel)
Chang HH, Chang PTS, Tsai CC, Kuo CY.
europepmc   +1 more source

Phenotypic Exploration in Patients with Heterozygous Variant in AFG3L2 Gene: A Case‐Series and Literature Review

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Variants in AFG3‐Like Matrix AAA Peptidase, Subunit 2 (AFG3L2) gene are associated with diverse clinical phenotypes. Here, we describe phenotypic findings of two unrelated children with de novo heterozygous variant and one family with inherited heterozygous variant in AFG3L2 gene.
Sangeetha Yoganathan, Laura Tochen, Jacky Ganguly, Sayoni Roy Chowdhury, Haya S AlFaris, Vivek Pai, Andrea LeBlanc‐Millar, Sara Breitbart, Hrishikesh Kumar, Manohar Shroff, Arun Reginald, Grace Yoon, Alfonso Fasano, George M Ibrahim, Carolina Gorodetsky   +14 more
wiley   +1 more source

Karyopherin Dysfunction Is a Key Driver of Aging. [PDF]

Aging Cell
Lapierre LR.
europepmc   +1 more source

JAK2 Variant and Parkinsonian Syndromes: Coincidence or Pathophysiological Link?

Movement Disorders Clinical Practice, EarlyView.
Abstract Background JAK2 variants are a hallmark of myeloproliferative neoplasms (MPNs), including polycythemia vera and essential thrombocythemia. These disorders are often associated with thrombotic and inflammatory complications. From a movement disorder perspective, chorea is a rare but well‐recognized neurological occurrence in this context ...
Elena Ardila Jurado, Koustubh Bavdhankar, Divyani Garg, Francesca Magrinelli, Huw R. Morris, Kailash P. Bhatia   +5 more
wiley   +1 more source