Results 151 to 160 of about 48,911 (292)

Regulation of proteostasis during cell division

Misfolding and aggregation of proteins not only disrupt their functions but also perturb the functions of other proteins by co-aggregation. These processes challenge protein homeostasis (proteostasis) and subsequently lead to cellular aging and ...
Du, Shoukang
core   +1 more source

Targeting eIF5A combats breast cancer progression by ClpP‐dependent mitochondrial oxidative stress

Interdisciplinary Medicine, EarlyView.
This study identified the eIF5A‐ClpP axis as a key driver of breast cancer progression. Targeting eIF5A suppresses tumor growth by inducing ClpP‐dependent mitochondrial oxidative stress, revealing a novel therapeutic vulnerability. Abstract Breast cancer (BC) poses a persistent global health challenge, necessitating new therapeutic targets.
Jinmei Zhu, Baoyuan Tang, Bei Xie, Haohua Deng, Haitang Yang, Lei Ma, Ziqing Zhang, Yicheng Ma, Xingyuan Ma, Shuaiyang Wang, Jing Li, Lei Zhao, Wengui Shi, Linjing Li   +13 more
wiley   +1 more source

Protein stereo-folding and proteostasis: A new path for clinical and translational medicine. [PDF]

Clin Transl Med
Wang Y, Qiu Y, Wang X.
europepmc   +1 more source

Checking in on proteostasis

Nature Structural & Molecular Biology
Sakata, E., Hegde, R.S., Zhao, Y.G., Ito, T., Radford, S.E., Hatzgolou, M., Jakob, U., Park, E., Lin, Y., Deuerling, E., Yang, P., Choe, Y.-J.   +11 more
openaire   +4 more sources

Air Pollution Quinones Impair Intestinal Barrier Integrity and Endoplasmic Reticulum in Differentiated Caco‐2 Cells

Journal of Applied Toxicology, EarlyView.
ABSTRACT Particulate matter (PM) is a major global health threat, linked to millions of deaths annually. Beyond inhalation, PM components reach the gastrointestinal tract through the mucociliary escalator or contaminated food and water. Among PM's organic fraction, redox‐active quinones such as 1,2‐naphthoquinone (NQ) and 9,10‐phenanthrenequinone (PQ ...
Franco Cervellati, Giulia Trinchera, Alice Casoni, Alessandra Pecorelli, Mascia Benedusi, Maria Chiara Pietrogrande, Giuseppe Valacchi   +6 more
wiley   +1 more source

Focus on DnaJ protein research from Arabidopsis to crop improvement. [PDF]

Plant Genome
Arif M, Rehman HM, Bashir S, Mahmood N, Srivastava AK, Kuzyakov Y, Ansari MS, Lam HM, Yang M.   +8 more
europepmc   +1 more source

Cellular Proteostasis and Solid Tumors

, 2018
La protéostase cellulaire représente l'ensemble des mécanismes régulant la production, le repliement, le transport et la dégradation des protéines dans la cellule afin de maintenir son homéostasie.
Sauzay, Chloé
core  

Improving protein secretion with autophagy‐inhibiting or proteasome‐activating small molecules

Journal of Chemical Technology &Biotechnology, EarlyView.
Abstract BACKGROUND Therapeutic proteins are produced frequently by mammalian cells in large‐scale bioreactors. As a result, producer cells are exposed to a chemically (nutrients, gas exchange, target protein overexpression) and physically (shear due to mixing) stressful environment, which can lead to endoplasmic reticulum (ER) stress and loss of ...
R Chauncey Splichal, Christina Chan, S Patrick Walton   +2 more
wiley   +1 more source

Advancing a systems-level understanding of neurodegeneration: the BrightFocus Alzheimer's disease research portfolio. [PDF]

Mol Neurodegener
Rossi SL, Bovenkamp DE.
europepmc   +1 more source

Salt‐induced nutritional and metabolic shifts in halophytes: implications for food security

Journal of the Science of Food and Agriculture, EarlyView.
Abstract Plant species vary in their response to salinity: some crops show a degree of salt tolerance, while halophytes – whether wild or cultivated – are characterized by a high capacity to thrive under saline conditions. Halophytes are considered a source of valuable secondary metabolites with potential economic value, yet they might also produce ...
Giulia Atzori, Pedro Garcia Caparros, Antonella Castagna, Luisa Custódio, Valentina Lazazzara, Claus Krogh Madsen, Felicia Menicucci, Maria João Rodrigues, Katalin Solymosi, Jose Ramon Acosta Motos   +9 more
wiley   +1 more source