Results 181 to 190 of about 56,365 (241)

Treating age‐related loss of muscle mass and function: Where should we be focusing?

The Journal of Physiology, EarlyView.
Abstract figure legend Perturbations contributing to the age‐related loss of muscle mass and strength. A, in the spinal cord, self‐reinforcing cycles of oxidative stress, mitochondrial dysfunction and inflammation mediated by cells, including microglia, contribute to motor neuron degeneration.
Daniel J. Ham, Christopher S. Fry, Avnika Ashok Ruparelia, Shyuan T. Ngo, Séverine Lamon   +4 more
wiley   +1 more source

Exercise serum promotes DNA damage repair and remodels gene expression in colon cancer cells

International Journal of Cancer, Volume 158, Issue 10, Page 2641-2649, 15 May 2026.
What's New? Exercise releases bioactive molecules into the bloodstream that can directly slow cancer cell growth. In colon cancer, this may help limit disease progression. Here, using colon cancer cells, the authors investigated the effects of exercise‐conditioned human serum on DNA repair mechanisms. Notably, acute exercise in humans elicited systemic
Samuel T. Orange, Emily Dodd, Sharanya Nath, Hannah Bowden, Alastair R. Jordan, Hannah Tweddle, Ann Hedley, Ifeoma Chukwuma, Ian Hickson, Sweta Sharma Saha   +9 more
wiley   +1 more source

NAD⁺ restores proteostasis through splicing-dependent autophagy. [PDF]

Autophagy
Ai R, Fang EF.
europepmc   +1 more source

The Ubiquitin Ligase Zinc Finger SWIM Domain‐Containing Protein 8 Regulates Oligodendrocyte Development Through the Argonaute2/MicroRNA‐7 Axis

Glia, Volume 74, Issue 5, May 2026.
ZSWIM8, an E3 ubiquitin ligase that broadly targets IDR‐rich proteins, drives MiR‐7‐dependent AGO2 degradation and the turnover of many RBPs. Loss of ZSWIM8 leads to MiR‐7 accumulation in oligodendrocyte progenitor cells and myelination defects in the developing brain. ABSTRACT Proteostasis of proteins with intrinsically disordered regions (IDRs) is of
Jing Lei, Siming Zhong, Rong Fan, Xin Shu, Guan Wang, Jiansheng Guo, Shuting Xue, Luqian Zheng, Aiming Ren, Junfang Ji, Bing Yang, Shumin Duan, Zhiping Wang, Xing Guo   +13 more
wiley   +1 more source

Correlated Evolutionary Rates Reveal Novel Components and Cross-Compartment Connectivity in Plant Proteostasis Systems. [PDF]

Genome Biol Evol
Gatts TC, Rehmann EA, Lane LE, Sloan DB, Forsythe ES.   +4 more
europepmc   +1 more source

Hematopoietic Stem Cells Require Elevated Protein Quality Control [PDF]

, 2018
Dillingham, Christopher, Hatters, Danny, Hong, Yuning, Kruta, Miriama, San Jose, Lorena Hidalgo, Signer, Robert, Sunshine, Mary Jean   +6 more
core  

Folding, misfolding, and regulation of intracellular traffic of G protein‐coupled receptors involved in the hypothalamic–pituitary–gonadal axis

Andrology, Volume 14, Issue 4, Page 978-991, May 2026.
Abstract Background G protein‐coupled receptors are a large and functionally diverse family of membrane receptors involved in a number of biological processes. Like other proteins, G protein‐coupled receptors need to be properly folded in order to traffic to the plasma membrane and interact with agonist.
Alfredo Ulloa‐Aguirre, Ross C. Anderson, Teresa Zariñán, Rubén Gutiérrez‐Sagal, Eduardo Jardón‐Valadez, Claire L. Newton   +5 more
wiley   +1 more source

Adaptive inter-tissue proteostasis networks in aging and neurodegeneration. [PDF]

Biosci Rep
Vergani-Junior CA, Ventura MAVC, De-Souza EA.   +2 more
europepmc   +1 more source

Chaperone‐Mediated Autophagic Degradation of USP9X in Macrophages Exacerbates Postmyocardial Infarction Inflammation and Cardiac Dysfunction

Advanced Science, Volume 13, Issue 19, 2 April 2026.
This study demonstrates that inflammatory stimuli induce the acetylation‐triggered, chaperone‐mediated autophagic degradation of ubiquitin‐specific peptidase 9 X‐linked (USP9X) in macrophages. USP9X acts as a macrophage “inflammation switch” after myocardial infarction (MI). USP9X loss destabilizes tumor necrosis factor receptor‐associated factor (TRAF)
Biqing Wang, Xiangheng Cai, Mengqi Li, Xue Liu, Junhui Xue, Ye Liu, Ding Ai, Xinyang Hu   +7 more
wiley   +1 more source

Mitofusin MFN2 acts as a molecular sensor preventing protein aggregation and mitophagy, with a protective effect against apoptosis in Charcot-Marie-Tooth type 2A disease. [PDF]

Autophagy Rep
Joaquim M, Dohrn MF, Chevrollier A, Escobar-Henriques M.   +3 more
europepmc   +1 more source