Results 191 to 200 of about 56,365 (241)

Ginsenoside Rb1 Ameliorates Age‐Related Cognitive Impairment Potentially by Modulating the NF‐κB Signaling Pathway

Brain and Behavior, Volume 16, Issue 4, April 2026.
Ginsenoside Rb1 may alleviate age‐related cognitive impairment by suppressing hippocampal inflammation, potentially through modulation of the NF‐κB signaling pathway. Abstract Introduction: Age‐related cognitive impairment affects the quality of life of the elderly, contributing to a substantial healthcare burden.
Wei‐Feng Lu, Yu‐Zhen Zhang, Zhi‐Gang Chen, Qun‐Lin Xiao, Shi‐Ye Ke   +4 more
wiley   +1 more source

FUS and TDP-43 aggregation are uncoupled from toxicity in ageing yeast models. [PDF]

BMC Biol
McDonald DW, Chugh N, Sava R, Duennwald ML.   +3 more
europepmc   +1 more source

Small Molecule‐Based Conditional Gene Regulation: Advances and Applications

Chemistry–Methods, Volume 6, Issue 4, April 2026.
The precise, temporal, and reversible control of gene expression using small molecule ligands is crucial for understanding complex cellular functions and is rapidly advancing the field of synthetic biology. Small molecule‐mediated conditional gene regulation has widespread applications, including bio‐manufacturing, cellular reprogramming, gene therapy,
Mohd Afaque Ansari, Riddhima Sharma, Priyanka Swami, Ambadas B. Rode   +3 more
wiley   +1 more source

Enhanced oxidative stress resilience in <i>C. elegans acox-1.1</i> mutants through CTL-3 and proteasomal regulation. [PDF]

Exp Biol Med (Maywood)
Bae W, Norman M, Lee MH.
europepmc   +1 more source

Evaluating Transcriptomic Biomarkers for rHuEPO Detection: Assessing the Impact of Exercise and Altitude Exposure

Drug Testing and Analysis, Volume 18, Issue 4, Page 581-602, April 2026.
A two‐stage transcriptomic filter comparing rHuEPO, exercise and altitude responses reduced 153 candidate genes to 50 that were unaffected by physiological stimuli. These retained transcripts offer focused biomarker leads to strengthen antidoping detection of rHuEPO.
Daria Obratov, Shaun Sutehall, Longhua Liu, Zhao Zhongying, Yannis Pitsiladis   +4 more
wiley   +1 more source

Correction Paschou et al., Dysregulated proteostasis in p.A53T-α-Synuclein astrocytes aggravates Lewy-like neuropathology in a Parkinson's disease iPSC model. [PDF]

Proc Natl Acad Sci U S A
europepmc   +1 more source

The immunoproteasome as a neuroimmune hub in the central nervous system: from proteostasis stress to inflammatory pathology. [PDF]

J Neuroinflammation
Zhao H, Liu Y, Chen X.
europepmc   +1 more source

The NAD World 2.0: the importance of the inter-tissue communication mediated by NAMPT/NAD+/SIRT1 in mammalian aging and longevity control [PDF]

, 2016
Imai, Shin-ichiro
core   +2 more sources

A Narrative Review of Antioxidant, Anti‐Inflammatory, Anti‐Apoptotic, Immunomodulatory, and Anticancer Properties of Rosa damascena Mill.

Food Science &Nutrition, Volume 14, Issue 4, April 2026.
Rosa damascena Mill. exhibits a broad spectrum of pharmacological activities mediated by its rich phytochemical profile. The plant enhances antioxidant defenses by increasing endogenous enzymes (CAT, SOD, GSH, GST, GPx, FRAP) and reducing oxidative stress markers (MDA, MPO).
Mahboobeh Ghasemzadeh Rahbardar, Nikta Soltani, Mohammad Hossein Boskabady   +2 more
wiley   +1 more source

Maternal Undernutrition Alters Fetal Muscle Growth, Metabolism, and Transcriptomic Regulation in Intrauterine Growth Restricted Sheep

Food Science &Nutrition, Volume 14, Issue 4, April 2026.
Maternal undernutrition in late pregnancy restricts fetal skeletal muscle growth and shifts muscle fiber types to fast muscle types. These changes are driven by changes in mitochondrial enzymes and DNA, endoplasmic reticulum stress, and ribosomal activity that predispose postnatal offspring to metabolic disorders.
Yina Qiao, Yilin Yang, Yang Zi, Chi Ma, Min Zhang, Xusheng Hao, Yingchun Liu, Feng Gao   +7 more
wiley   +1 more source