Results 211 to 220 of about 56,365 (241)

Supervised learning of protein variant effects across large‐scale mutagenesis datasets

Protein Science, Volume 35, Issue 4, April 2026.
Abstract The increasing availability of data from multiplexed assays of variant effects (MAVEs) enables supervised model training against large quantities of experimental data to learn sequence‐function relationships. Variant effect scores from MAVEs can, however, be influenced by the experimental method and library composition, resulting in experiment‐
Thea K. Schulze, Lasse M. Blaabjerg, Matteo Cagiada, Kresten Lindorff‐Larsen   +3 more
wiley   +1 more source

The proteostasis network is a therapeutic target in acute myeloid leukemia.

Blood
Lam K, Kim YJ, Tan EL, Ong CM, Liu AZ, Zhou FJ, Sunshine MJ, Chua BA, Vicenzi S, Chen K, Yu H, Ford PW, Zhou JH, Hong Y, Bennett EJ, Crews LA, Ball ED, Signer RAJ.   +17 more
europepmc   +1 more source

Small heat shock proteins HspB1 and HspB5 differentially alter the condensation and aggregation of the TDP‐43 low‐complexity domain

Protein Science, Volume 35, Issue 4, April 2026.
Abstract TAR DNA‐binding protein 43 (TDP‐43) is a nucleic acid‐binding protein that regulates processes of mRNA metabolism, during which it undergoes condensation mediated by its C‐terminal low‐complexity domain (TDP‐43LCD). TDP‐43 aggregation and condensation are associated with neurodegenerative disease.
Thomas B. Walker, Joshua W. Trowbridge, Shannon McMahon, Nicholas R. Marzano, Lauren Rice, Justin J. Yerbury, Heath Ecroyd, Luke McAlary   +7 more
wiley   +1 more source

Phosphatidylcholine coordinates ER-autonomous and ER-nonautonomous adaptations to unfolded protein response dysfunction. [PDF]

J Biol Chem
Tong H, Li W, Yuan P, Wang X, Pang S, Tang H.   +5 more
europepmc   +1 more source

The complexities of respiratory chain biogenesis and maintenance in yeast mitochondria

Protein Science, Volume 35, Issue 4, April 2026.
Abstract Mitochondrial oxidative phosphorylation is the most efficient way of energy conversion for eukaryotic cells. It is executed by a series of high‐molecular weight enzyme complexes in the inner mitochondrial membrane that were acquired during endosymbiosis at the root of eukaryotic evolution.
Andreas Carlström, Carmela Vazquez‐Calvo, Martin Ott   +2 more
wiley   +1 more source

Tau Phosphorylation as an Adaptive Physiological Response: Implications for the Therapy of Tauopathies. [PDF]

FASEB J
Daly T, Imbimbo BP.
europepmc   +1 more source

Impact of Fire and Heat Stress on Soil Microorganisms: A Review of Community Changes, Molecular Responses and Plant‐Beneficial Roles

Environmental Microbiology Reports, Volume 18, Issue 2, April 2026.
This work reviewed the direct and indirect effects of fires on microbial communities and the resilience strategies microbes use to withstand high temperatures . ABSTRACT Fire, whether occurring on the surface or underground, significantly influences soil microbial dynamics by reshaping community composition, functional diversity and overall soil and ...
Ma. del Carmen Orozco‐Mosqueda, Aurora Flores‐Piña, Ajay Kumar, Fannie I. Parra‐Cota, Sergio de los Santos‐Villalobos, Debasis Mitra, Olubukola Oluranti Babalola, Gustavo Santoyo   +7 more
wiley   +1 more source

Nrf2-Activating Natural Compounds in Neurodegenerative Diseases: Targeting Oxidative Stress and Protein Aggregation. [PDF]

Int J Mol Sci
Chico L, Schirinzi E, Balestrini L, Polzella M, Siciliano G.   +4 more
europepmc   +1 more source

Targeting Mitochondrial Stress Responses: Terbinafine and Miglustat as Novel Lifespan and Healthspan Modulators

Aging Cell, Volume 25, Issue 4, April 2026.
Terbinafine and miglustat are mitohormetic compounds that extend lifespan and healthspan. In C. elegans, these FDA‐approved drugs engage both ATFS‐1 and DAF‐16, highlighting a stress‐dependent coordination between mitochondrial and IIS pathways distinct from canonical IIS activation, relevant for healthy aging.
Amélia Lalou, Ioanna Daskalaki, Ilias Gkikas, Sandra Rodríguez‐López, Jean‐David Morel, Giorgia Benegiamo, Adrien Faure, Arwen W. Gao, Joaquim Barmaz, Qi Wang, Terytty Yang Li, Feng Gao, Danaé Broustail, Kristina Schoonjans, Giovanni D'Angelo, Johan Auwerx   +15 more
wiley   +1 more source

Multilayered regulation of longevity in Caenorhabditis elegans. [PDF]

Mol Cells
Bong D, Kwon HC, Lee SV.
europepmc   +1 more source