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Glioblastoma as Developmental Stress Boundary Displacement: Insect Embryonic Cells as Quantitative Reference Platforms for Mitochondrial Adaptation-A Conceptual Framework. [PDF]
Rzeski W.
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Emerging New Pathways in Malignant Neoplasms and Neurodegenerative Disorders: Perspectives for Therapeutics. [PDF]
Wrasidlo W, Masliah E.
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Dynamic Cellular Regulation of Proteasome Translocation and Phase Transition. [PDF]
Butcher C, Li J.
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Autophagy in Alzheimer's Disease: Mechanisms, Clinical Trials, and Horizons.
Tshimbombu TN +8 more
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Extracellular Chaperones and Proteostasis
There exists a family of currently untreatable, serious human diseases that arise from the inappropriate misfolding and aggregation of extracellular proteins. At present our understanding of mechanisms that operate to maintain proteostasis in extracellular body fluids is limited, but it has significantly advanced with the discovery of a small but ...
Heath Ecroyd, Amy Wyatt, Mark Wilson
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2021
Abstract Normal cell function and survival depend on carefully regulated synthesis, folding, trafficking, and degradation of proteins. The balance among these processes is referred to as proteostasis. Proteins undergo maturation and folding in the endoplasmic reticulum. This process is error-prone and can be affected by mutations, errors
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Abstract Normal cell function and survival depend on carefully regulated synthesis, folding, trafficking, and degradation of proteins. The balance among these processes is referred to as proteostasis. Proteins undergo maturation and folding in the endoplasmic reticulum. This process is error-prone and can be affected by mutations, errors
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Nature Medicine, 2015
Accumulation of intracellular damage is an almost universal hallmark of aging. An improved understanding of the systems that contribute to cellular protein quality control has shed light on the reasons for the increased vulnerability of the proteome to stress in aging cells.
Susmita Kaushik, Ana Maria Cuervo
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Accumulation of intracellular damage is an almost universal hallmark of aging. An improved understanding of the systems that contribute to cellular protein quality control has shed light on the reasons for the increased vulnerability of the proteome to stress in aging cells.
Susmita Kaushik, Ana Maria Cuervo
openaire +2 more sources

