Results 241 to 250 of about 48,911 (292)

Autophagy in Alzheimer's Disease: Mechanisms, Clinical Trials, and Horizons.

open access: yesNeurodegener Dis
Tshimbombu TN   +8 more
europepmc   +1 more source

Extracellular Chaperones and Proteostasis

open access: yesAnnual Review of Biochemistry, 2013
There exists a family of currently untreatable, serious human diseases that arise from the inappropriate misfolding and aggregation of extracellular proteins. At present our understanding of mechanisms that operate to maintain proteostasis in extracellular body fluids is limited, but it has significantly advanced with the discovery of a small but ...
Heath Ecroyd, Amy Wyatt, Mark Wilson
exaly   +5 more sources

Proteostasis

2021
Abstract Normal cell function and survival depend on carefully regulated synthesis, folding, trafficking, and degradation of proteins. The balance among these processes is referred to as proteostasis. Proteins undergo maturation and folding in the endoplasmic reticulum. This process is error-prone and can be affected by mutations, errors
openaire   +2 more sources

Proteostasis and aging

Nature Medicine, 2015
Accumulation of intracellular damage is an almost universal hallmark of aging. An improved understanding of the systems that contribute to cellular protein quality control has shed light on the reasons for the increased vulnerability of the proteome to stress in aging cells.
Susmita Kaushik, Ana Maria Cuervo
openaire   +2 more sources

Home - About - Disclaimer - Privacy