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The proteostasis network is a therapeutic target in acute myeloid leukemia.

Blood
Lam K, Kim YJ, Tan EL, Ong CM, Liu AZ, Zhou FJ, Sunshine MJ, Chua BA, Vicenzi S, Chen K, Yu H, Ford PW, Zhou JH, Hong Y, Bennett EJ, Crews LA, Ball ED, Signer RAJ.   +17 more
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Mitochondria-Associated Proteostasis

Annual Review of Biophysics, 2020
Mitochondria are essential organelles in eukaryotes. Most mitochondrial proteins are encoded by the nuclear genome and translated in the cytosol. Nuclear-encoded mitochondrial proteins need to be imported, processed, folded, and assembled into their functional states.
Yuhao Wang, Joshua T Mcnamara
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Proteostasis

2021
Abstract Normal cell function and survival depend on carefully regulated synthesis, folding, trafficking, and degradation of proteins. The balance among these processes is referred to as proteostasis. Proteins undergo maturation and folding in the endoplasmic reticulum. This process is error-prone and can be affected by mutations, errors
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Proteostasis and aging

Nature Medicine, 2015
Accumulation of intracellular damage is an almost universal hallmark of aging. An improved understanding of the systems that contribute to cellular protein quality control has shed light on the reasons for the increased vulnerability of the proteome to stress in aging cells.
Susmita Kaushik, Ana Maria Cuervo
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Pathways of cellular proteostasis in aging and disease

Journal of Cell Biology, 2018
Ensuring cellular protein homeostasis, or proteostasis, requires precise control of protein synthesis, folding, conformational maintenance, and degradation. A complex and adaptive proteostasis network coordinates these processes with molecular chaperones
Courtney L Klaips, Gopal Gunanathan Jayaraj, F Ulrich Hartl   +2 more
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Proteostasis and SUMO in the heart

The International Journal of Biochemistry & Cell Biology, 2016
Heart proteostasis relies on a complex and integrated network of molecular processes surveilling organ performance under physiological and pathological conditions. For this purpose, cardiac cells depend on the correct function of their proteolytic systems, such as the ubiquitin-proteasome system (UPS), autophagy and the calpain system.
Elisa Da Silva-Ferrada, Teresa M. Ribeiro-Rodrigues, Manuel S. Rodríguez, Henrique Girão   +3 more
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Cellular Proteostasis in Neurodegeneration

Molecular Neurobiology, 2018
The term proteostasis reflects the fine-tuned balance of cellular protein levels, mediated through a vast network of biochemical pathways. This requires the regulated control of protein folding, post-translational modification, and protein degradation.
Alberim Kurtishi, Benjamin Rosen, Ketan S. Patil, Guido W. Alves, Simon G. Møller   +4 more
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The Nucleolus as a Proteostasis Regulator

Trends in Cell Biology, 2019
Protein misfolding is linked to disease, so how do mammalian cells cope with the burden of misfolded proteins in the nucleus? A recent study in Science (Frottin et al., 2019) demonstrated that on proteotoxic stress, the nucleolus could store some misfolded proteins for refolding or degradation.
Fatima, Amer-Sarsour, Avraham, Ashkenazi
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Proteostasis: The network behind the networks

Seminars in Cell & Developmental Biology, 2019
It is difficult to find a biomedical review article or attend a seminar that does not depict a cellular signaling pathway, schematically drawn out to make sense of the complex interactions that underlie a particular biological process. These cartoons usually depict key proteins as solid, static shapes, connected by arrows, usually cascading from a ...
Barrio, R, Sutherland, JD
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