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Mitochondria-Associated Proteostasis
Annual Review of Biophysics, 2020Mitochondria are essential organelles in eukaryotes. Most mitochondrial proteins are encoded by the nuclear genome and translated in the cytosol. Nuclear-encoded mitochondrial proteins need to be imported, processed, folded, and assembled into their functional states.
Yuhao Wang, Joshua T McNamara
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Proteostasis and SUMO in the heart
The International Journal of Biochemistry & Cell Biology, 2016Heart proteostasis relies on a complex and integrated network of molecular processes surveilling organ performance under physiological and pathological conditions. For this purpose, cardiac cells depend on the correct function of their proteolytic systems, such as the ubiquitin-proteasome system (UPS), autophagy and the calpain system.
Elisa Da Silva-Ferrada +3 more
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Cellular Proteostasis in Neurodegeneration
Molecular Neurobiology, 2018The term proteostasis reflects the fine-tuned balance of cellular protein levels, mediated through a vast network of biochemical pathways. This requires the regulated control of protein folding, post-translational modification, and protein degradation.
Alberim Kurtishi +4 more
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The Nucleolus as a Proteostasis Regulator
Trends in Cell Biology, 2019Protein misfolding is linked to disease, so how do mammalian cells cope with the burden of misfolded proteins in the nucleus? A recent study in Science (Frottin et al., 2019) demonstrated that on proteotoxic stress, the nucleolus could store some misfolded proteins for refolding or degradation.
Fatima, Amer-Sarsour, Avraham, Ashkenazi
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Proteostasis: The network behind the networks
Seminars in Cell & Developmental Biology, 2019It is difficult to find a biomedical review article or attend a seminar that does not depict a cellular signaling pathway, schematically drawn out to make sense of the complex interactions that underlie a particular biological process. These cartoons usually depict key proteins as solid, static shapes, connected by arrows, usually cascading from a ...
Barrio, R, Sutherland, JD
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Pathways of cellular proteostasis in aging and disease
Journal of Cell Biology, 2018 Ensuring cellular protein homeostasis, or proteostasis, requires precise control of protein synthesis, folding, conformational maintenance, and degradation. A complex and adaptive proteostasis network coordinates these processes with molecular chaperones
Gopal Jayaraj, F Ulrich Hartl
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Proteostasis in neurodegenerative diseases
Proteostasis is essential for normal function of proteins and vital for cellular health and survival. Proteostasis encompasses all stages in the "life" of a protein, that is, from translation to functional performance and, ultimately, to degradation. Proteins need native conformations for function and in the presence of multiple types of stress, their ...Sumit, Kinger +8 more
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2023
Proteostasis, the control of all aspects of assembly, turnover and removal of proteins within the cellular proteome by a proteostasis network of ∼2000 proteins present in all tissues, is achieved through both acute, nutritionally-sensitive, within tissue mechanisms, throughout the diurnal-cycle of feeding and fasting and through more long-term, between-
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Proteostasis, the control of all aspects of assembly, turnover and removal of proteins within the cellular proteome by a proteostasis network of ∼2000 proteins present in all tissues, is achieved through both acute, nutritionally-sensitive, within tissue mechanisms, throughout the diurnal-cycle of feeding and fasting and through more long-term, between-
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2020
Proteostasis regulates key cellular processes such as cell proliferation, differentiation, transcription, and apoptosis. The mechanisms by which proteostasis is regulated are crucial and the deterioration of cellular proteostasis has been significantly associated with tumorigenesis since it specifically targets key oncoproteins and tumor suppressors ...
Erbaykent Tepedelen, Burcu +3 more
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Proteostasis regulates key cellular processes such as cell proliferation, differentiation, transcription, and apoptosis. The mechanisms by which proteostasis is regulated are crucial and the deterioration of cellular proteostasis has been significantly associated with tumorigenesis since it specifically targets key oncoproteins and tumor suppressors ...
Erbaykent Tepedelen, Burcu +3 more
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Protecting the future: balancing proteostasis for reproduction
Trends in Cell Biology, 2022Richard Morimoto
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