Results 221 to 230 of about 62,588 (334)

Chimeric degraders in neurodegenerative diseases: Challenges and future directions. [PDF]

J Transl Int Med
Zheng H, Cui K, Mao J, Wan Y, Zheng J.
europepmc   +1 more source

Protoplast‐Based Functional Genomics and Genome Editing: Progress, Challenges and Applications

Plant, Cell &Environment, EarlyView.
ABSTRACT Protoplast‐based systems provide a powerful and versatile platform for exploring how plants sense and respond to their environment. By enabling the direct delivery of proteins, DNA, and RNA into plant cells after cell wall removal, this approach facilitates precise molecular dissection of signaling, stress adaptation, and gene regulation ...
Jo‐Wei Allison Hsieh, Fu‐Hui Wu, Dian‐Xuan Yang, Ai‐En Wu, Ching‐Ann Liu, Chang‐Hung Chen, Shinn‐Zong Lin, Ying‐Chung Jimmy Lin, Choun‐Sea Lin   +8 more
wiley   +1 more source

Phosphatidylcholine coordinates ER-autonomous and ER-nonautonomous adaptations to unfolded protein response dysfunction. [PDF]

J Biol Chem
Tong H, Li W, Yuan P, Wang X, Pang S, Tang H.   +5 more
europepmc   +1 more source

Longitudinal metabolomics study of phosphate‐adenine‐guanosine‐glucose‐saline‐mannitol stored red blood cells

Transfusion, EarlyView.
Abstract Background The storage of red blood cells (RBCs) is essential for transfusion but leads to storage lesions that compromise RBC quality and increase the risk of transfusion‐related adverse effects, including allergic transfusion reactions (ATRs). Understanding storage‐induced metabolic change is crucial for enhancing transfusion safety.
Gürkan Bal, Maia Dzamashvili, Zhuoran Li, Magda Babina, Nidal Toman, Abdulgabar Salama   +5 more
wiley   +1 more source

Multilayered regulation of longevity in Caenorhabditis elegans. [PDF]

Mol Cells
Bong D, Kwon HC, Lee SV.
europepmc   +1 more source

Microgravity‐induced changes in skeletal muscle and possible countermeasures: What we can learn from bed rest and human space studies

Experimental Physiology, EarlyView.
Abstract Despite exercise countermeasures to sustain health and performance in spaceflight, complete maintenance of muscle mass and functions in microgravity is still not possible for most astronauts. The principal cause of the limited effectiveness of existing exercise countermeasures is the difficulty in achieving full loading forces in space.
Alessandra Bosutti, Bergita Ganse, Nicola A. Maffiuletti, Rob C. I. Wüst, Gustav J. Strijkers, Andy Sanderson, Hans Degens   +6 more
wiley   +1 more source

Turning over new ideas in human skeletal muscle proteostasis: What do we know and where to from here?

Experimental Physiology, EarlyView.
Abstract Understanding the turnover of proteins in tissues gives information as to how external stimuli result in phenotypic change. Nowhere is such phenotypic change more conspicuous than skeletal muscle, which can be effectively remodelled by increased loading, ageing and unloading (disuse), all of which are subject to modification by nutrition and ...
Changhyun Lim, James McKendry, Matthew Lees, Philip J. Atherton, Nicholas A. Burd, Andrew M. Holwerda, Luc J. C. van Loon, Chris McGlory, Cameron J. Mitchell, Kenneth Smith, Daniel J. Wilkinson, Tanner Stokes, Stuart M. Phillips   +12 more
wiley   +1 more source

Signal relay in C. elegans: A tissue-perspective on coordinating organismal proteostasis and its impact on aging. [PDF]

Cell Stress Chaperones
Cocciolone L, Souparnika A, Uvarova V, Kessler K, van Oosten-Hawle P.   +4 more
europepmc   +1 more source

Applying lessons from limb muscle disuse and ageing to better understand ventilator‐induced diaphragm dysfunction

Experimental Physiology, EarlyView.
Abstract Mechanical ventilation (MV) is a life‐saving intervention applied to critically ill patients. A common consequence of MV is ventilator‐induced diaphragm dysfunction (VIDD), which is characterized by significant diaphragm atrophy and reduced contractile function. Older patients who receive MV are more likely to develop VIDD, have worse recovery,
P. H. C. Mesquita, J. L. Halle, J. D. Fuqua, B. F. Miller   +3 more
wiley   +1 more source

Molecular Mechanisms and Therapeutic Potential of Degron-Mediated Proteostasis Regulation in Neurodegenerative Diseases. [PDF]

Cell Mol Neurobiol
Nishanth DS, Sinha U, Verma T, Kalidass B, Thirumuruganandham SP, Kodiveri Muthukaliannan G.   +5 more
europepmc   +1 more source