Results 1 to 10 of about 145,615 (142)

Induction of prothrombin synthesis by prothrombin fragments. [PDF]

Proceedings of the National Academy of Sciences, 1981
The mechanisms by which blood levels of prothrombin (PT) are regulated in the vitamin K-sufficient state are unknown. We have studied PT synthesis by Reuber H-35 rat hepatoma cells exposed to vitamin K and [3H]leucine in serum-free cultures. Administration to the culture system of exogenous bovine PT and rat PT was characterized by increases in ...
Arnold W. Strauss, Gregory A. Grant, C. B. Graves, T. W. Munns, T. L. Carlisle   +4 more
openaire   +3 more sources

The Conversion of Bovine Abnormal Prothrombin into Prothrombin [PDF]

Thrombosis and Haemostasis, 1977
In order to characterize the enzyme system which converts abnormal prothrombin (PIVKA-II) in prothrombin we prepared liver cell-free extracts from normal healthy cows. The enzyme system devoid of either precursor or prothrombin was isolated by differential centrifugation and partly purified with the aid of column chromatography.The carboxylation of ...
H.C. Hemker, Berry A.M. Soute, Cees Vermeer   +2 more
openaire   +1 more source

Three- versus four-factor prothrombin complex concentrate for the reversal of warfarin-induced bleeding [PDF]

, 2018
Objective: The objective of this study was to evaluate the effectiveness of 3-factor prothrombin complex concentrate (3F-PCC) compared to 4-factor PCC (4F-PCC) in warfarin-associated bleeding. Methods: This multicenter, retrospective, cohort study
Abraham, Prasad, Curtis, James, Elder, Tai, Harris, Serena, Holt, Tara, Mcmillian, Wesley, Taylor, Scott   +6 more
core   +1 more source

Reference materials (RMs) for analysis of the human factor II (prothrombin) gene G20210A mutation [PDF]

, 2005
The Scientific Committee of Molecular Biology Techniques (C-MbT) in Clinical Chemistry of the IFCC has initiated a joint project in co-operation with the European Commission, Joint Research Centre, Institute of Reference Materials and Measurements to ...
Cooper, S., Corbisier, Philippe, Gancberg, David, Gemmati, Donato, Halbmayer, Walter-Michael, Kitchen, Steve, Klein, Christoph L., Mannhalter, Christine, Marki-Zay, János, Melegh, Béla, Neumaier, Michael, Oldenburg, Johannes, Opplinger Leibundgut, Elisabeth, Reitsma, Pieter H., Rieger, Sandra, Schimmel, Heinz G., Spannagl, Michael, Tordai, Attilia, Tosetto, Alberto, Visvikis, Sophie, Zadro, Renata   +20 more
core   +8 more sources

Pharmacokinetics and efficacy of oral versus intravenous mixed-micellar phylloquinone (vitamin K-1) in severe acute liver disease [PDF]

, 2005
Background/Aims: In patients with severe acute liver dysfunction, i.v. phylloquinone (vitamin K-1) may be given to exclude vitamin K deficiency, rather than impaired hepatic synthesis of coagulation factors alone, as the cause of the coagulopathy ...
Fitt, S, Pereira, SP, Rowbotham, D, Shearer, MJ, Wendon, J, Williams, R   +5 more
core   +1 more source

Oral contraceptives, hormone replacement therapy, thrombophilias and risk of venous thromboembolism: a systematic review The Thrombosis: Risk and Economic Assessment of Thrombophilia Screening (TREATS) Study [PDF]

, 2005
Combined oral contraceptives,oral hormone replacement therapy and thrombophilias are recognised risk factors for venous thromboembolism in women.The objective of this study was to assess the risk of thromboembolism among women with thrombophilia who are ...
Brenkel, I., Clark, P., Greaves, M., Greer, I.A., Langhorne, P., Lowe, G.D.O., Regan, L., Robertson, L., Twaddle, S., Walker, I.D., Wu, O.   +10 more
core   +1 more source

How we treat bleeding associated with direct oral anticoagulants [PDF]

, 2016
Direct oral anticoagulants are at least as effective as vitamin K antagonists for the prevention and treatment of thromboembolism. Unfortunately, differently from vitamin K antagonists, they have the great drawback of lacking specific antidotes in the ...
Franchini, Massimo, Liumbruno, Giancarlo M, Marano, Giuseppe, Pupella, Simonetta, VAGLIO, Stefania   +4 more
core   +1 more source

Non-canonical proteolytic activation of human prothrombin by subtilisin from Bacillus subtilis may shift the procoagulant\ue2\u80\u93anticoagulant equilibrium toward thrombosis [PDF]

, 2017
Blood coagulation is a finely regulated physiological process culminating with the factor Xa (FXa)-mediated conversion of the prothrombin (ProT) zymogen to active -thrombin (T).
Acquasaliente, Laura, Artusi, Ilaria, De Filippis, Vincenzo, Frasson, Roberta, Peterle, Daniele, Pontarollo, Giulia   +5 more
core   +1 more source

Hormonal replacement therapy, prothrombotic mutations and the risk of venous thrombosis [PDF]

, 2002
Hormone replacement therapy (HRT) increases the risk of venous thrombosis. We investigated whether this risk is affected by carriership of hereditary prothrombotic abnormalities.
A. Rumley, Anderson, Bloemenkamp, Daly, E. Daly, F. M. Helmerhorst, F. R. Rosendaal, G. D. O. Lowe, Grady, Grodstein, Hulley, Jick, Kniffin, Lowe, M. Vessey, M. Woodward, Mehta, Nordström, Oger, Rees, Rosendaal, Rosendaal, Silverstein, Stadel, Vandenbroucke, Vessey, Woolf   +26 more
core   +1 more source

Testing for inherited thrombophilia does not reduce the recurrence of venous thrombosis\ud [PDF]

, 2008
Background: Inherited thrombophilia is only weakly associated with recurrence in patients with a first venous thrombosis (VT). In spite of this, thrombophilia testing is often performed in these patients. Positive results may influence patient management
Coppens, M., Doggen, C.J.M., Middeldorp, S., Reijnders, J.H., Rosendaal, F.R.   +4 more
core   +2 more sources