Results 1 to 10 of about 153,196 (149)

Cryo-EM structure of the prothrombin-prothrombinase complex

Blood, 2022
In this Plenary Paper, Ruben et al determine structures of the prothrombinase complex that are responsible for the proteolytic conversion of prothrombin to thrombin, the penultimate step in the coagulation cascade.
E. Ruben, B. Summers, M. Rau, James Fitzpatrick, E. Di Cera   +4 more
semanticscholar   +1 more source

Prolonged prothrombin time at admission predicts poor clinical outcome in COVID-19 patients

World Journal of Clinical Cases, 2020
BACKGROUND The prognostic value of coagulation disorder in coronavirus disease 2019 (COVID-19) patients should be demonstrated. AIM To investigate the abnormalities of coagulation parameters in the patients with COVID-19 and their prognostic values ...
Lang Wang, Wenbo He, Xiaomei Yu, Dalong Hu, Hong Jiang   +4 more
semanticscholar   +1 more source

Prothrombin complex concentrate vs. fresh frozen plasma in adult patients undergoing heart surgery – a pilot randomised controlled trial (PROPHESY trial)

Anaesthesia, 2020
There is equipoise regarding the use of prothrombin complex concentrate vs. fresh frozen plasma in bleeding patients undergoing cardiac surgery. We performed a pilot randomised controlled trial to determine the recruitment rate for a large trial ...
L. Green, N. Roberts, J. Cooper, S. Agarwal, S. Brunskill, I. Chang, R. Gill, A. Johnston, A. Klein, S. Platton, A. Rossi, A. Sepehripour, S. Stanworth, V. Monk, B. O'Brien   +14 more
semanticscholar   +1 more source

Rivaroxaban reversal with prothrombin complex concentrate or tranexamic acid in healthy volunteers

Journal of Thrombosis and Haemostasis, 2018
Essentials Specific reversal agents for managing severe factor Xa inhibitor‐associated bleeding are lacking. We assessed 4‐factor‐prothrombin complex concentrate (4F‐PCC) and tranexamic acid (TXA).
J. Levy, K. Moore, M. Neal, D. Schneider, V. S. Marcsisin, J. Ariyawansa, J. Weitz   +6 more
semanticscholar   +1 more source

Edoxaban Effects on Bleeding Following Punch Biopsy and Reversal by a 4-Factor Prothrombin Complex Concentrate

Circulation, 2015
Background— The oral factor Xa inhibitor edoxaban has demonstrated safety and efficacy in stroke prevention in patients with atrial fibrillation and in the treatment and secondary prevention of venous thromboembolism. This study investigated the reversal
H. Zahir, K. Brown, A. Vandell, Madhuri Desai, J. Maa, V. Dishy, Barbara Lomeli, A. Feussner, Wenqin Feng, Ling He, M. Grosso, H. Lanz, E. Antman   +12 more
semanticscholar   +1 more source

Prothrombin conversion is accelerated in the antiphospholipid syndrome and insensitive to thrombomodulin.

Blood Advances, 2018
Antiphospholipid syndrome (APS) is a condition in which the presence of antibodies against phospholipid-binding proteins is associated with thrombophilia and/or pregnancy morbidity.
R. Kremers, S. Zuily, H. Kelchtermans, T. Peters, S. Bloemen, V. Regnault, H. Hemker, P. D. de Groot, D. Wahl, B. de Laat   +9 more
semanticscholar   +1 more source

Prothrombin Complex Concentrates for Perioperative Vitamin K Antagonist and Non–vitamin K Anticoagulant Reversal

Anesthesiology, 2018
Vitamin K antagonist therapy is associated with an increased bleeding risk, and clinicians often reverse anticoagulation in patients who require emergency surgical procedures.
J. Levy, J. Douketis, T. Steiner, J. Goldstein, T. Milling   +4 more
semanticscholar   +1 more source

Structure of prothrombin in the closed form reveals new details on the mechanism of activation

Scientific Reports, 2018
The clotting factor prothrombin exists in equilibrium between closed and open conformations, but the physiological role of these forms remains unclear.
Mathivanan Chinnaraj, Zhiwei Chen, L. Pelc, Z. Grese, D. Bystranowska, E. Di Cera, N. Pozzi   +6 more
semanticscholar   +1 more source

Decreased prothrombin conversion and reduced thrombin inactivation explain rebalanced thrombin generation in liver cirrhosis

PLoS ONE, 2017
Impaired coagulation factor synthesis in cirrhosis causes a reduction of most pro- and anticoagulant factors. Cirrhosis patients show no clear bleeding or thrombotic phenotype, although they are at risk for both types of hemostatic event.
R. Kremers, Marie-Claire F. Kleinegris, M. Ninivaggi, B. de Laat, H. ten Cate, G. Koek, R. Wagenvoord, H. Hemker   +7 more
semanticscholar   +1 more source

Goal-directed coagulation management of major trauma patients using thromboelastometry (ROTEM®)-guided administration of fibrinogen concentrate and prothrombin complex concentrate

Critical Care, 2010
IntroductionThe appropriate strategy for trauma-induced coagulopathy management is under debate. We report the treatment of major trauma using mainly coagulation factor concentrates.MethodsThis retrospective analysis included trauma patients who received
H. Schöchl, U. Nienaber, Georg Hofer, W. Voelckel, C. Jámbor, G. Scharbert, S. Kozek‐Langenecker, C. Solomon   +7 more
semanticscholar   +1 more source