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Inherited thrombophilia in a Han Chinese family caused by prothrombin Ile441Met mutation [PDF]
Research and Practice in Thrombosis and HaemostasisBackground: Inherited thrombophilia (IT) is a genetically determined predisposition to thromboembolic events. Beyond the well-known G20210A mutation, there has been limited research on other prothrombin mutations in the Chinese population.
Si-Yuan Wen +8 more
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The Measurement of Prothrombin in Plasma: A Case of Prothrombin Deficiency [PDF]
Journal of Clinical Pathology, 1953 R Biggs, A. S. Douglas
openalex +4 more sources
Frontiers in Surgery, 2021 Objective: Postoperative anemia is a common complication after a major surgery. Our study aims to identify factors that are associated with higher risk of developing postoperative anemia after thoracic surgery.Methods: We conducted a retrospective study ...
Zhongping Lang, Yue Wu, Minwei Bao
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Cryo-EM structure of the prothrombin-prothrombinase complex
Blood, 2022 In this Plenary Paper, Ruben et al determine structures of the prothrombinase complex that are responsible for the proteolytic conversion of prothrombin to thrombin, the penultimate step in the coagulation cascade.
E. Ruben +4 more
semanticscholar +1 more source
Frontiers in Immunology, 2021 Antiphospholipid antibodies (aPL) are mandatory for the diagnosis but are also a risk factor for the antiphospholipid syndrome (APS) clinical manifestations.
Pier Luigi Meroni +2 more
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Association of prothrombin, FV Leiden and MTHFR gene polymorphisms in the Montenegrin patients with venous thromboembolism [PDF]
Vojnosanitetski Pregled, 2021 Background/Aim. Polymorphisms of the factor V Leiden (FV G1691A), prothrombin (FII G20210A), and methylene-tetrahydrofolate reductase (MTHFR C677T) genes are the most commonly investigated inherited risk factors for developing venous thromboembolism (VTE)
Teofilov Slađana +4 more
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Prothrombin expression in cancer-derived cell lines [PDF]
Archives of Biological Sciences, 2019 The link between thrombotic disorders and cancer has been known for over 150 years, although the precise mechanism of this relationship has not yet been resolved.
Dunjić Sofija +6 more
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Induction of prothrombin synthesis by prothrombin fragments. [PDF]
Proceedings of the National Academy of Sciences, 1981 The mechanisms by which blood levels of prothrombin (PT) are regulated in the vitamin K-sufficient state are unknown. We have studied PT synthesis by Reuber H-35 rat hepatoma cells exposed to vitamin K and [3H]leucine in serum-free cultures. Administration to the culture system of exogenous bovine PT and rat PT was characterized by increases in ...
Arnold W. Strauss +4 more
openaire +3 more sources
OPTIMIZATION OF THE EVALUATION METHOD OF THE PERFORMANCE OF THERAPY USING INDIRECT ACTION ANTICOAGULANTS [PDF]
Biotechnologia Acta, 2022 Aim. Treatment by indirect anticoagulants (vitamin K antagonists) requires a personalized approach for controlling the overall level of prothrombin and the accumulation of its decarboxylated forms.
D. S. Korolova +6 more
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Standardization of Prothrombin Time/International Normalized Ratio (PT/INR)
International Journal of Laboratory Hematology, 2020 The prothrombin time (PT) represents the most commonly used coagulation test in clinical laboratories. The PT is mathematically converted to the international normalized ratio (INR) for use in monitoring anticoagulant therapy with vitamin K antagonists ...
A. Dorgalaleh +3 more
semanticscholar +1 more source