Results 31 to 40 of about 153,345 (297)

Prognostic value of lupus anticoagulant and anti‐β2 glycoprotein I antibody in adverse pregnancy outcomes.

Arthritis &Rheumatology, Accepted Article.
Objective International criteria for antiphospholipid syndrome (APS) include lupus anticoagulant (LA), anticardiolipin (aCL) immunoglobulin (Ig) G and IgM, and anti‐β2‐glycoprotein I (β2GPI) IgG and IgM. However, evidence supporting their prognostic value or treatment efficacy in improving live birth rates is limited.
Megumi Nonobe, Takahiro Otani, Hiroyuki Yoshihara, Shinobu Goto, Tamao Kitaori, Naomi Nishikawa, Yuichiro Fujieda, Tatsuya Atsumi, Mayumi Sugiura‐Ogasawara   +8 more
wiley   +1 more source

Risk of venous thromboembolism and myocardial infarction associated with factor V Leiden and prothrombin mutations and blood type

Canadian Medical Association Journal, 2013
Background: ABO blood type locus has been reported to be an important genetic determinant of venous and arterial thrombosis in genome-wide association studies. We tested the hypothesis that ABO blood type alone and in combination with mutations in factor
B. F. Sode, K. H. Allin, M. Dahl, F. Gyntelberg, B. Nordestgaard   +4 more
semanticscholar   +1 more source

Ethnomedicinal Uses, Phytochemistry, Pharmacological Activities, and Toxicology of the Subfamily Gomphrenoideae (Amaranthaceae): A Comprehensive Review

Chemistry &Biodiversity, EarlyView.
ABSTRACT The subfamily Gomphrenoideae is composed of about 480 accepted species, many of which have been historically used as medicinal plants, reason why they have been studied in terms of chemical profile, biological activity, and safety. This review consolidates the advances in research on this subfamily over the past 47 years, emphasizing its ...
Dayanna Isabel Araque Gelves, Giulia Cristina de Andreoli Souza, Alvaro Jose Hernandez Tasco, Marcos José Salvador   +3 more
wiley   +1 more source

Severe Vasoplegic Syndrome Treated with Angiotensin II and Hemoadsorption Therapy after Cardiac Surgery

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Vasoplegic syndrome (VS) is a common complication after cardiac surgery with cardiopulmonary bypass (CPB). The main pathophysiology mechanism of VS includes a systemic inflammatory response syndrome due to surgical trauma, release of pro‐inflammatory mediators caused by blood contact with foreign surfaces of heart‐lung machine (pump and tubing)
Matteo Lucchelli, Davide Tommaso Andreis, Mattia Gomarasca, Giovanni Mistraletti   +3 more
wiley   +1 more source

Crystal Structure of Prothrombin Reveals Conformational Flexibility and Mechanism of Activation*

Journal of Biological Chemistry, 2013
Background: The x-ray structure and mechanism of activation of prothrombin remain elusive. Results: X-ray and solution studies document conformation flexibility of prothrombin.
N. Pozzi, Zhiwei Chen, D. Gohara, W. Niu, T. Heyduk, E. Di Cera   +5 more
semanticscholar   +1 more source

Navigating the Uncertainties of Antithrombotic Therapy After Transcatheter Patent Foramen Ovale Closure: A Comprehensive Review

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT The patent foramen ovale (PFO), present in 25% of the population, can cause paradoxical embolism and stroke. Transcatheter PFO closure is the gold standard for recurrent embolism with significant inter‐atrial shunting, with recent trials confirming its superiority in reducing ischemic stroke recurrence over medical therapy.
Eirini Beneki, Kyriakos Dimitriadis, Nikolaos Pyrpyris, Georgios Tzimas, Ioannis Skalidis, David Meier, Panagiotis Antiochos, Panagiotis Kostakis, Efthymia Pavlou, Francesco Perone, Georgios Tsivgoulis, Constantina Aggeli, Ole de Backer, Konstantinos Tsioufis   +13 more
wiley   +1 more source

Prothrombin complex concentrate in the reduction of blood loss during orthotopic liver transplantation: PROTON-trial

BMC Surgery, 2013
BackgroundIn patients with cirrhosis, the synthesis of coagulation factors can fall short, reflected by a prolonged prothrombin time. Although anticoagulants factors are decreased as well, blood loss during orthotopic liver transplantation can still be ...
Freeha Arshad, B. Ickx, Rachel T van Beem, W. Polak, F. Grüne, F. Nevens, M. Ilmakunnas, A. Koivusalo, H. Isoniemi, P. Strengers, H. Groen, H. Hendriks, T. Lisman, J. Pirenne, R. Porte   +14 more
semanticscholar   +1 more source

Site‐Specific Antithrombotic Therapy: 24‐Month Outcomes of the Randomized DESyne BDS Plus Trial Using a Novel Triple‐Drug Eluting Coronary Implant With Two Anticoagulants and Sirolimus

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background DESyne BDS Plus represents a novel triple drug therapy (TRx) applied on a coronary stent platform eluting the antiproliferative drug Sirolimus along with two anticoagulants (Rivaroxaban and Argatroban) to reduce the site‐specific thrombotic risk.
Stefan Verheye, Bert Ferdinande, Johan Bennett, Rodolfo Staico, Seif El‐Jack, Pim A. L. Tonino, Alexandre Abizaid, Ian Buysschaert, Douglas Scott, Madhav Menon, Gerard Wilkins, Dougal McClean, Tomas Kovarnik, Uwe Christians, Antoinette Neylon, Zlatko Mehmedbegovic, Pieter C. Smits, Marie‐Claude Morice, Mark Webster, the DESyne BDS Plus RCT Investigators   +19 more
wiley   +1 more source

Quantitative Model‐Informed Dose Selection for a Milvexian Phase III Study in Patients With Atrial Fibrillation

Clinical Pharmacology &Therapeutics, EarlyView.
Milvexian, an activated factor XI inhibitor, is being evaluated in the LIBREXIA phase III program for the prevention of thrombotic events, including in patients with atrial fibrillation (LIBREXIA AF). To guide the selection of a phase III dose regimen for LIBREXIA AF, two main approaches were used: (1) population pharmacokinetics and exposure–response ...
Wangda Zhou, Emily Bozenhardt, Gregory E. Alexander, Matthew L. Zierhut, Samira Merali, Antoinette Ajavon‐Hartmann, Peter Zannikos, Hyunmoon Back, EunYoung Suh, Navin Goyal, Mahesh N. Samtani, Alexei N. Plotnikov, Chandni Valiathan   +12 more
wiley   +1 more source

Histone H4 Promotes Prothrombin Autoactivation*

Journal of Biological Chemistry, 2013
Background: The molecular origin of the prothrombotic properties of histones is unknown. Results: Histone H4 interacts with prothrombin and promotes autoactivation. Conclusion: The prothrombotic properties of histone H4 are due to direct interaction with
Sergio Barranco-Medina, N. Pozzi, Austin D. Vogt, E. Di Cera   +3 more
semanticscholar   +1 more source