Results 21 to 30 of about 5,052 (178)
Thermally driven fission of protocells [PDF]
Biophysical Journal, 2021 We propose a simple mechanism for the self-replication of protocells. Our main hypothesis is that the amphiphilic molecules composing the membrane bilayer are synthesised inside the protocell through globally exothermic chemical reactions. The slow increase of the inner temperature forces the hottest molecules to move from the inner leaflet to the ...
Romain, Attal, Laurent, Schwartz
openaire +3 more sources
Evolution of linkage and genome expansion in protocells: The origin of chromosomes.
PLoS Genetics, 2020 Chromosomes are likely to have assembled from unlinked genes in early evolution. Genetic linkage reduces the assortment load and intragenomic conflict in reproducing protocell models to the extent that chromosomes can go to fixation even if chromosomes ...
András Szilágyi +3 more
doaj +1 more source
Non-interfacial self-assembly of synthetic protocells
Biomaterials Research, 2023 Background Protocell refers to the basic unit of life and synthetic molecular assembly with cell structure and function. The protocells have great applications in the field of biomedical technology.
Xiaolin Xu +4 more
doaj +1 more source
The targeted delivery of multicomponent cargos to cancer cells by nanoporous particle-supported lipid bilayers. [PDF]
, 2011 Encapsulation of drugs within nanocarriers that selectively target malignant cells promises to mitigate side effects of conventional chemotherapy and to enable delivery of the unique drug combinations needed for personalized medicine.
Ashley, Carlee E +20 more
core +2 more sources
Protocells: At the Interface of Life and Non-Life
Life, 2015 The cellular form, manifesting as a membrane-bounded system (comprising various functional molecules), is essential to life. The ultimate reason for this is that, typically, one functional molecule can only adopt one “correct” structure to perform one ...
Wentao Ma, Yu Feng
doaj +1 more source
Accounts of Chemical Research, 2012 Prebiotic soup experiments have shown that the molecular building blocks of life can be built under prebiotically plausible conditions. From this starting point, researchers have launched continued studies of polymerization and explorations of the breadth of RNA function.
Del Bianco, Cristina +1 more
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Shape Deformation, Budding and Division of Giant Vesicles and Artificial Cells: A Review
Life, 2022 The understanding of the shape-change dynamics leading to the budding and division of artificial cells has gained much attention in the past few decades due to an increased interest in designing stimuli-responsive synthetic systems and minimal models of ...
Ylenia Miele +3 more
doaj +1 more source
A stochastic model of catalytic reaction networks in protocells [PDF]
, 2014 Protocells are supposed to have played a key role in the self-organizing processes leading to the emergence of life. Existing models either (i) describe protocell architecture and dynamics, given the existence of sets of collectively self-replicating ...
Damiani, Chiara +5 more
core +1 more source
SURFACE-REACTION MODELS OF PROTOCELLS [PDF]
BIOMAT 2006, 2007 We present a class of models aiming to describe generic protocells hypotheses, improving a model introduced elsewhere[13]. These models, inspired by the 'Los Alamos bug' hypothesis, are composed by two coupled subsystems: a self-replicating molecule-SRM- and a lipid container.
SERRA, Roberto, T. CARLETTI, I. POLI
openaire +5 more sources
Electrostatically gated membrane permeability in inorganic protocells [PDF]
, 2013 Although several strategies are now available to produce functional microcompartments analogous to primitive cell-like structures, little progress has been made in generating protocell constructs with self-controlled membrane permeability.
A Boker +30 more
core +4 more sources