Results 41 to 50 of about 5,052 (178)

Investigating Prebiotic Protocells for a Comprehensive Understanding of the Origins of Life: A Prebiotic Systems Chemistry Perspective

open access: yesLife, 2019
Protocells are supramolecular systems commonly used for numerous applications, such as the formation of self-evolvable systems, in systems chemistry and synthetic biology.
Augustin Lopez, Michele Fiore
doaj   +1 more source

Natural selection. III. Selection versus transmission and the levels of selection [PDF]

open access: yes, 2011
George Williams defined an evolutionary unit as hereditary information for which the selection bias between competing units dominates the informational decay caused by imperfect transmission.
Frank, Steven A.
core   +2 more sources

Passive endocytosis in model protocells

open access: yesProceedings of the National Academy of Sciences, 2023
AbstractSemipermeable membranes are a key feature of all living organisms. While specialized membrane transporters in cells can import otherwise impermeable nutrients, the earliest cells would have lacked a mechanism to import nutrients rapidly under nutrient-rich circumstances.
Stephanie J. Zhang   +6 more
openaire   +4 more sources

Macrophage Reprogramming with Anti‐miR223‐Loaded Artificial Protocells Enhances In Vivo Cancer Therapeutic Potential

open access: yesAdvanced Science, 2022
Several immune cell‐expressed miRNAs (miRs) are associated with altered prognostic outcome in cancer patients, suggesting that they may be potential targets for development of cancer therapies.
Paco López‐Cuevas   +7 more
doaj   +1 more source

Synthetic protocells interact with viral nanomachinery and inactivate pathogenic human virus.

open access: yesPLoS ONE, 2011
We present a new antiviral strategy and research tool that could be applied to a wide range of enveloped viruses that infect human beings via membrane fusion.
Matteo Porotto   +3 more
doaj   +1 more source

Sequence‐Modulated Active Tripeptide Condensates for Tandem Catalysis

open access: yesAngewandte Chemie, Volume 138, Issue 13, 23 March 2026.
Sequence‐modulated tripeptide coacervates mimic biomolecular condensates with controllable, enzyme‐regulated phase separation. They co‐sequester hydrophobic active species and hydrophilic enzymes, enabling tandem catalysis in aqueous media. Incorporated into artificial cells, they function as adaptive sub‐organelles, orchestrating compartmentalized ...
Hao Han   +7 more
wiley   +2 more sources

Dynamic Transcription Machineries in Protocells. [PDF]

open access: yesJ Am Chem Soc
Transcription machineries play key roles in nature by regulating diverse cellular processes, including cell cycle progression, the control of intracellular metabolic balance, and cell differentiation and growth. These processes are regulated by the programmed transcription factor-mediated operation of transcription machineries and cellular ...
Dong J, Xia F, Huang F, Willner I.
europepmc   +3 more sources

UV-light-driven prebiotic synthesis of iron–sulfur clusters [PDF]

open access: yes, 2017
Iron–sulfur clusters are ancient cofactors that play a fundamental role in metabolism and may have impacted the prebiotic chemistry that led to life.
Bonfio, Claudia   +13 more
core   +1 more source

A scaling law of multilevel evolution: how the balance between within- and among-collective evolution is determined

open access: yes, 2021
Numerous living systems are hierarchically organised, whereby replicating components are grouped into reproducing collectives -- e.g., organelles are grouped into cells, and cells are grouped into multicellular organisms.
Kaneko, Kunihiko   +2 more
core   +1 more source

Survival of RNA Replicators Is Much Easier in Protocells Than in Surface-Based, Spatial Systems

open access: yesLife, 2019
In RNA-World scenarios for the origin of life, replication is catalyzed by polymerase ribozymes. Replicating RNA systems are subject to invasion by non-functional parasitic strands. It is well-known that there are two ways to avoid the destruction of the
Vismay Shah   +4 more
doaj   +1 more source

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