Results 1 to 10 of about 11,003 (167)

Computational vaccine development against protozoa [PDF]

Computational and Structural Biotechnology Journal
Protozoan parasites remain a major global health and economic burden, particularly in low- and middle-income countries. Conventional strategies such as chemotherapy and vector control face growing limitations due to resistance, toxicity, and ...
Omar Hashim, Isabelle Dimier-Poisson
doaj   +2 more sources

A state-of-the-art methodology for high-throughput in silico vaccine discovery against protozoan parasites and exemplified with discovered candidates for Toxoplasma gondii

Scientific Reports, 2023
Vaccine discovery against eukaryotic parasites is not trivial as highlighted by the limited number of known vaccines compared to the number of protozoal diseases that need one. Only three of 17 priority diseases have commercial vaccines.
Stephen J. Goodswen, Paul J. Kennedy, John T. Ellis   +2 more
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Effect of Parasitic Infections on Hematological Profile, Reproductive and Productive Performance in Equines [PDF]

Animals
Equines play a crucial role in global food security, economic development, and recreation, particularly in regions such as Central Asia, parts of Africa, and South America.
Abd Ullah, Mingyang Geng, Wenting Chen, Qifei Zhu, Limeng Shi, Xuemin Zhang, Muhammad Faheem Akhtar, Changfa Wang, Muhammad Zahoor Khan   +8 more
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CRISPR/Cas9 Ribonucleoprotein-Based Genome Editing Methodology in the Marine Protozoan Parasite Perkinsus marinus

Frontiers in Bioengineering and Biotechnology, 2021
Perkinsus marinus (Perkinsozoa), a close relative of apicomplexans, is an osmotrophic facultative intracellular marine protozoan parasite responsible for “Dermo” disease in oysters and clams.
Raghavendra Yadavalli, Kousuke Umeda, Kousuke Umeda, Hannah A. Waugh, Hannah A. Waugh, Adrienne N. Tracy, Adrienne N. Tracy, Asha V. Sidhu, Asha V. Sidhu, Derek E. Hernández, Derek E. Hernández, José A. Fernández Robledo   +11 more
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The GP-45 Protein, a Highly Variable Antigen from Babesia bigemina, Contains Conserved B-Cell Epitopes in Geographically Distant Isolates

Pathogens, 2022
In B. bigemina, the 45 kilodaltons glycoprotein (GP-45) is the most studied. GP-45 is exposed on the surface of the B. bigemina merozoite, it is believed to play a role in the invasion of erythrocytes, and it is characterized by a high genetic and ...
Miguel Angel Mercado-Uriostegui, Luis Alberto Castro-Sánchez, Gaber El-Saber Batiha, Uriel Mauricio Valdez-Espinoza, Alfonso Falcón-Neri, Juan Alberto Ramos-Aragon, Ruben Hernández-Ortiz, Shin-Ichiro Kawazu, Ikuo Igarashi, Juan Mosqueda   +9 more
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Identification and Characterization of Rhipicephalus microplus ATAQ Homolog from Haemaphysalis longicornis Ticks and Its Immunogenic Potential as an Anti-Tick Vaccine Candidate Molecule

Microorganisms, 2023
Although vaccines are one of the environmentally friendly means to prevent the spread of ticks, there is currently no commercial vaccine effective against Haemaphysalis longicornis ticks.
Paul Franck Adjou Moumouni, Souichirou Naomasa, Bumduuren Tuvshintulga, Nariko Sato, Kiyoshi Okado, Weiqing Zheng, Seung-Hun Lee, Juan Mosqueda, Hiroshi Suzuki, Xuenan Xuan, Rika Umemiya-Shirafuji   +10 more
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Spherical Body Protein 4 from Babesia bigemina: A Novel Gene That Contains Conserved B-Cell Epitopes and Induces Cross-Reactive Neutralizing Antibodies in Babesia ovata

Pathogens, 2023
Bovine babesiosis is a tick-transmitted disease caused by intraerythrocytic protozoan parasites of the genus Babesia. Its main causative agents in the Americas are Babesia bigemina and Babesia bovis, while Babesia ovata affects cattle in Asia.
Juan Mosqueda, Diego Josimar Hernandez-Silva, Massaro W. Ueti, Adolfo Cruz-Reséndiz, Ricardo Marquez-Cervantez, Uriel Mauricio Valdez-Espinoza, Minh-Anh Dang-Trinh, Thu-Thuy Nguyen, Minerva Camacho-Nuez, Miguel Angel Mercado-Uriostegui, Gabriela Aguilar-Tipacamú, Juan Alberto Ramos-Aragon, Ruben Hernandez-Ortiz, Shin-ichiro Kawazu, Ikuo Igarashi   +14 more
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VLP-Based Vaccines as a Suitable Technology to Target Trypanosomatid Diseases

Vaccines, 2021
Research on vaccines against trypanosomatids, a family of protozoa that cause neglected tropical diseases, such as Chagas disease, leishmaniasis, and sleeping sickness, is a current need.
Aline Maria Vasconcelos Queiroz, Johny Wysllas de Freitas Oliveira, Cláudia Jassica Moreno, Diego M. A. Guérin, Marcelo Sousa Silva   +4 more
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Recent Advances in the Development of Adenovirus-Vectored Vaccines for Parasitic Infections

Pharmaceuticals, 2023
Vaccines against parasites have lagged centuries behind those against viral and bacterial infections, despite the devastating morbidity and widespread effects of parasitic diseases across the globe.
Cal Koger-Pease, Dilhan J. Perera, Momar Ndao   +2 more
doaj   +1 more source

Melittin as a promising anti-protozoan peptide: current knowledge and future prospects

AMB Express, 2021
Protozoan diseases such as malaria, leishmaniasis, Chagas disease, and sleeping sickness still levy a heavy toll on human lives. Deplorably, only few classes of anti-protozoan drugs have thus far been developed. The problem is further compounded by their
Hamed Memariani, Mojtaba Memariani
doaj   +1 more source