Results 1 to 10 of about 11,109 (130)

Next-Generation Vaccines Against Neglected Diseases: New Promises from Genetically Modified Live-Attenuated Parasites and RNA Vaccines [PDF]

Microorganisms
Different protozoan parasites are the causative agents of tropical diseases, including malaria, toxoplasmosis, leishmaniasis, and Chagas disease (CD), which, altogether, affect over 300 million people throughout the world.
Marina Ferreira Batista-Zauli, Maria Eduarda Carvalho Guimarães Brasil, Carlos Roberto de Almeida-Júnior, Bárbara Germana Soares de Abreu, Nailma Silva Aprigio dos Santos, Mayra Fernanda Ricci, Santuza Maria Ribeiro Teixeira   +6 more
doaj   +2 more sources

Computational vaccine development against protozoa [PDF]

Computational and Structural Biotechnology Journal
Protozoan parasites remain a major global health and economic burden, particularly in low- and middle-income countries. Conventional strategies such as chemotherapy and vector control face growing limitations due to resistance, toxicity, and ...
Omar Hashim, Isabelle Dimier-Poisson
doaj   +2 more sources

Heterologous Prime–Boost Vaccination with GRA35-Encoding DNA and mRNA Vaccines Enhances Protective Immunity Against Toxoplasma gondii Infection in Mouse Models [PDF]

Microorganisms
Toxoplasma gondii is an obligate intracellular protozoan parasite that causes toxoplasmosis, posing a significant threat to human health and livestock production worldwide.
Sisi Chen, Rui Li, Yanyan Zhu, Jie Sun, Jia Chen   +4 more
doaj   +2 more sources

Protozoan co-infections and parasite influence on the efficacy of vaccines against bacterial and viral pathogens

Frontiers in Microbiology, 2022
A wide range of protozoan pathogens either transmitted by vectors (Plasmodium, Babesia, Leishmania and Trypanosoma), by contaminated food or water (Entamoeba and Giardia), or by sexual contact (Trichomonas) invade various organs in the body and cause ...
Lavoisier Akoolo, Nikhat Parveen, Sandra Rocha   +2 more
exaly   +3 more sources

The Stem Cell Revolution Revealing Protozoan Parasites’ Secrets and Paving the Way towards Vaccine Development

Vaccines, 2021
Protozoan infections are leading causes of morbidity and mortality in humans and some of the most important neglected diseases in the world. Despite relentless efforts devoted to vaccine and drug development, adequate tools to treat and prevent most of ...
Alena Panče, Panče Alena
exaly   +3 more sources

Effect of Parasitic Infections on Hematological Profile, Reproductive and Productive Performance in Equines [PDF]

Animals
Equines play a crucial role in global food security, economic development, and recreation, particularly in regions such as Central Asia, parts of Africa, and South America.
Abd Ullah, Mingyang Geng, Wenting Chen, Qifei Zhu, Limeng Shi, Xuemin Zhang, Muhammad Faheem Akhtar, Changfa Wang, Muhammad Zahoor Khan   +8 more
doaj   +2 more sources

CRISPR/Cas9 Ribonucleoprotein-Based Genome Editing Methodology in the Marine Protozoan Parasite Perkinsus marinus

Frontiers in Bioengineering and Biotechnology, 2021
Perkinsus marinus (Perkinsozoa), a close relative of apicomplexans, is an osmotrophic facultative intracellular marine protozoan parasite responsible for “Dermo” disease in oysters and clams.
JOSÉ A Fernandez Robledo
exaly   +3 more sources

The GP-45 Protein, a Highly Variable Antigen from Babesia bigemina, Contains Conserved B-Cell Epitopes in Geographically Distant Isolates

Pathogens, 2022
In B. bigemina, the 45 kilodaltons glycoprotein (GP-45) is the most studied. GP-45 is exposed on the surface of the B. bigemina merozoite, it is believed to play a role in the invasion of erythrocytes, and it is characterized by a high genetic and ...
Miguel Angel Mercado-Uriostegui, Luis Alberto Castro-Sánchez, Gaber El-Saber Batiha, Uriel Mauricio Valdez-Espinoza, Alfonso Falcón-Neri, Juan Alberto Ramos-Aragon, Ruben Hernández-Ortiz, Shin-Ichiro Kawazu, Ikuo Igarashi, Juan Mosqueda   +9 more
doaj   +1 more source

Identification and Characterization of Rhipicephalus microplus ATAQ Homolog from Haemaphysalis longicornis Ticks and Its Immunogenic Potential as an Anti-Tick Vaccine Candidate Molecule

Microorganisms, 2023
Although vaccines are one of the environmentally friendly means to prevent the spread of ticks, there is currently no commercial vaccine effective against Haemaphysalis longicornis ticks.
Paul Franck Adjou Moumouni, Souichirou Naomasa, Bumduuren Tuvshintulga, Nariko Sato, Kiyoshi Okado, Weiqing Zheng, Seung-Hun Lee, Juan Mosqueda, Hiroshi Suzuki, Xuenan Xuan, Rika Umemiya-Shirafuji   +10 more
doaj   +1 more source

Spherical Body Protein 4 from Babesia bigemina: A Novel Gene That Contains Conserved B-Cell Epitopes and Induces Cross-Reactive Neutralizing Antibodies in Babesia ovata

Pathogens, 2023
Bovine babesiosis is a tick-transmitted disease caused by intraerythrocytic protozoan parasites of the genus Babesia. Its main causative agents in the Americas are Babesia bigemina and Babesia bovis, while Babesia ovata affects cattle in Asia.
Juan Mosqueda, Diego Josimar Hernandez-Silva, Massaro W. Ueti, Adolfo Cruz-Reséndiz, Ricardo Marquez-Cervantez, Uriel Mauricio Valdez-Espinoza, Minh-Anh Dang-Trinh, Thu-Thuy Nguyen, Minerva Camacho-Nuez, Miguel Angel Mercado-Uriostegui, Gabriela Aguilar-Tipacamú, Juan Alberto Ramos-Aragon, Ruben Hernandez-Ortiz, Shin-ichiro Kawazu, Ikuo Igarashi   +14 more
doaj   +1 more source