Results 21 to 30 of about 11,003 (167)

The genome of the protozoan parasite Cystoisospora suis and a reverse vaccinology approach to identify vaccine candidates [PDF]

International Journal for Parasitology, 2017
Vaccine development targeting protozoan parasites remains challenging, partly due to the complex interactions between these eukaryotes and the host immune system. Reverse vaccinology is a promising approach for direct screening of genome sequence assemblies for new vaccine candidate proteins.
Palmieri, N, Shrestha, A, Ruttkowski, B, Beck, T, Vogl, C, Tomley, F M, Blake, D P, Joachim, A   +7 more
openaire   +2 more sources

Lessons Learned from Protective Immune Responses to Optimize Vaccines against Cryptosporidiosis

Pathogens, 2017
In developing countries, cryptosporidiosis causes moderate-to-severe diarrhea and kills thousands of infants and toddlers annually. Drinking and recreational water contaminated with Cryptosporidium spp.
Maxime W. Lemieux, Karine Sonzogni-Desautels, Momar Ndao   +2 more
doaj   +1 more source

Sporozoite immunization: Innovative Translational Science to Support the Fight against malaria

Expert Review of Vaccines, 2023
Introduction Malaria, a devastating febrile illness caused by protozoan parasites, sickened 247,000,000 people in 2021 and killed 619,000, mostly children and pregnant women in sub-Saharan Africa. A highly effective vaccine is urgently needed, especially
Thomas L. Richie, L.W. Preston Church, Tooba Murshedkar, Peter F. Billingsley, Eric R. James, Mei-Chun Chen, Yonas Abebe, Natasha KC, Sumana Chakravarty, David Dolberg, Sara A. Healy, Halimatou Diawara, Mahamadou S. Sissoko, Issaka Sagara, David M. Cook, Judith E. Epstein, Benjamin Mordmüller, Melissa Kapulu, Andrea Kreidenweiss, Blandine Franke-Fayard, Selidji T. Agnandji, María-Silvia A. López Mikue, Matthew B.B. McCall, Laura Steinhardt, Martina Oneko, Ally Olotu, Ashley M. Vaughan, James G. Kublin, Sean C. Murphy, Said Jongo, Marcel Tanner, Sodiomon B. Sirima, Matthew B. Laurens, Claudia Daubenberger, Joana C. Silva, Kirsten E. Lyke, Chris J. Janse, Meta Roestenberg, Robert W. Sauerwein, Salim Abdulla, Alassane Dicko, Stefan H. I. Kappe, B. Kim Lee Sim, Patrick E. Duffy, Peter G. Kremsner, Stephen L. Hoffman   +45 more
doaj   +1 more source

Tissue-resident, memory CD8+ T cells are effective in clearing intestinal Eimeria falciformis reinfection in mice

Frontiers in Immunology, 2023
Eimeria, a cousin of malarial parasites, causes coccidiosis that results in huge losses in the poultry industry. Although live coccidiosis vaccines have been developed and used widely for the successful control of the disease, the mechanism underlying ...
Fangyun Shi, Fangyun Shi, Fangyun Shi, Sixin Zhang, Sixin Zhang, Ning Zhang, Ning Zhang, Ying Yu, Ying Yu, Pei Sun, Xinming Tang, Xianyong Liu, Xianyong Liu, Xianyong Liu, Xun Suo, Xun Suo, Xun Suo   +16 more
doaj   +1 more source

Immunization with Leishmania tarentolae-derived norovirus virus-like particles elicits high humoral response and stimulates the production of neutralizing antibodies

Microbial Cell Factories, 2021
Background Noroviruses are a major cause of epidemic and sporadic acute non-bacterial gastroenteritis worldwide. Unfortunately, the development of an effective norovirus vaccine has proven difficult and no prophylactic vaccine is currently available ...
Mirosława Panasiuk, Karolina Zimmer, Anna Czarnota, Katarzyna Grzyb, Magdalena Narajczyk, Grażyna Peszyńska-Sularz, Sabina Żołędowska, Dawid Nidzworski, Lilit Hovhannisyan, Beata Gromadzka   +9 more
doaj   +1 more source

Efficacy of mucosal vaccination using a protozoan parasite as a vehicle for antigen delivery: IgG and neutralizing response after rectal administration of LeCoVax-2, a candidate vaccine against COVID-19

Pharmacological Research, 2022
Mucosal vaccination is regarded as a promising alternative to classical, intramuscular vaccine delivery. However, only a limited number of vaccines have been licensed for mucosal administration in humans. Here we propose Leishmania tarentolae, a protozoan parasite, as a potential antigen vehicle for mucosal vaccination, for administration via the ...
Epis, Sara, Varotto-Boccazzi, Ilaria, Manenti, Alessandro, Rubolini, Diego, Gabrieli, Paolo, Cattaneo, Giulia Maria, Gourlay, Louise, Dapporto, Francesca, Monti, Martina, Razzano, Ilaria, Leonardi, Margherita, Iannacone, Matteo, Recordati, Camilla, Bertola, Luca, Fiorina, Paolo, Marvasi, Luigi, Montomoli, Emanuele, Zuccotti, Gianvincenzo, Bandi, Claudio   +18 more
openaire   +4 more sources

Scalable Access to N‑Acylindole Linkages: Enabling the Synthesis of Antitrypanosomal Noncanonical Cyclic Peptides for Chagas Disease

Angewandte Chemie, Volume 138, Issue 15, 6 April 2026.
A gram‐scale supply of bulbiferamide A, which features a rare N‐acylindole linkage and possesses potent inhibitory activity against Trypanosoma cruzi epimastigotes (IC50 = 4.1 µM)—the causative parasite of Chagas disease—was successfully achieved. Moreover, the cyclization strategy developed in this study facilitated the synthesis of noncanonical ...
Jie Zhang, Hugh Nakamura
wiley   +2 more sources

Unravelling the Immunity of Poultry Against the Extracellular Protozoan Parasite Histomonas meleagridis Is a Cornerstone for Vaccine Development: A Review [PDF]

Frontiers in Immunology, 2018
The protozoan parasite Histomonas meleagridis is the causative agent of histomonosis in gallinaceous birds, predominantly in turkeys and chickens. Depending on the host species the outcome of the disease can be very severe with high mortality as observed in turkeys, whereas in chickens the mortality rates are generally lower.
Taniya Mitra, Fana Alem Kidane, Michael Hess, Michael Hess, Dieter Liebhart   +4 more
openaire   +3 more sources

Canines vaccinated against visceral leishmaniasis develop a serological response to the Leishmania braziliensis antigen

Semina: Ciências Agrárias, 2018
American cutaneous leishmaniasis (ACL) is a zoonosis caused by Leishmania, a protozoan. Common antigens occur in the strains found in America, which allow antigenic cross-reactivity. Therefore, multivalent vaccines can be used for this pathogen.
Julia de Assis Pinheiro, Silas Garcia Giori, Sayanne Luns Hatum de Almeida, Rafael Assis de Souza, Ana Paula Madureira, Marcos Santos Zanini   +5 more
doaj   +3 more sources

Genetically Modified Organisms and Visceral Leishmaniasis

Frontiers in Immunology, 2014
Vaccination is the most effective method of preventing infectious diseases. Since the eradication of small pox in 1976, many other potentially life compromising if not threatening diseases have been dealt with subsequently.
NAHID eALI, RUDRA eCHHAJER
doaj   +1 more source