Results 31 to 40 of about 11,109 (130)

Lipid and fatty acid metabolism in trypanosomatids

open access: yesMicrobial Cell, 2021
Trypanosomiases and leishmaniases are neglected tropical diseases that have been spreading to previously non-affected areas in recent years. Identification of new chemotherapeutics is needed as there are no vaccines and the currently available treatment ...
Giovana Parreira de Aquino   +3 more
doaj   +1 more source

Immune Consequences of Metabolic Syndrome and Its Treatment: A Cytokine Perspective

open access: yesImmunology, EarlyView.
Peripheral blood mononuclear cells (PBMCs) from individuals with metabolic syndrome (MetS) who were not using glucose‐and/or lipid lowering medication (GLLM) exhibited a broader cytokine production profile after in vitro antigen‐specific stimulation than PBMCs from individuals with MetS using such medications and from healthy donors.
Isabela Ghetti Macedo Isaac   +7 more
wiley   +1 more source

Parasite-Produced MIF Cytokine: Role in Immune Evasion, Invasion, and Pathogenesis

open access: yesFrontiers in Immunology, 2019
Protozoan parasites represent a major threat to health and contribute significantly to morbidity and mortality worldwide, especially in developing countries.
Swagata Ghosh   +4 more
doaj   +1 more source

Tick‐borne diseases in subtropical dairy farming: The role of calf rearing strategies in antibody and antigen prevalence Enfermedades Transmitidas por Garrapatas en la Ganadería Lechera subtropical: El Papel de las Estrategias de Crianza de Terneros en la Prevalencia de Anticuerpos y Antígenos

open access: yesMedical and Veterinary Entomology, EarlyView.
Tropical farmers try to adapt calf‐rearing systems to temperate dairy industry standards. Calves in tick‐infested areas develop stronger immunity to TBD under controlled exposure to ticks. Early tick exposure promotes sustainable management, balancing tick infestation and developing TBD immunity.
Daniela Balseca   +11 more
wiley   +1 more source

Canine Leishmaniosis in Italy: Geospatial Trends and Incidence, a Shift in Epidemiological Approach

open access: yesZoonoses and Public Health, EarlyView.
ABSTRACT Introduction Canine leishmaniosis (CanL) has shown a marked geographic expansion in Italy, progressively affecting central and northern regions previously considered non‐endemic. Laboratory‐based prevalence estimates remain informative in well‐designed surveys; however, prevalence derived from diagnostic submissions may be influenced by study ...
Federica Bruno   +16 more
wiley   +1 more source

The Delay in the Licensing of Protozoal Vaccines: A Comparative History

open access: yesFrontiers in Immunology, 2020
Although viruses and bacteria have been known as agents of diseases since 1546, 250 years went by until the first vaccines against these pathogens were developed (1796 and 1800s).
Clarisa Beatriz Palatnik-de-Sousa   +2 more
doaj   +1 more source

Dicentrine, an Aporphine Alkaloid From Ocotea langsdorffii, Induces Mitochondrial Dysfunction and Oxidative Stress in Leishmania (L.) infantum

open access: yesChemistry &Biodiversity, Volume 23, Issue 8, August 2026.
Dicentrine, an aporphine alkaloid, exhibits potent in vitro antileishmanial activity against Leishmania species with high selectivity and low macrophage cytotoxicity. Mechanistic studies reveal that the compound triggers parasite death possibly by inducing mitochondrial membrane disruption and oxidative stress.
Camila S. de Freitas   +9 more
wiley   +1 more source

Antibodies Targeting a Conserved Surface Polysaccharide Are Protective Against a Wide Range of Microbial Pathogens Producing β-1–6-Linked Poly-N-Acetylglucosamine (PNAG)

open access: yesEngineering
The β-1–6-linked poly-N-acetylglucosamine (PNAG) polymer is a conserved surface polysaccharide produced by many bacteria, fungi, and protozoan (and even filarial) parasites.
Xi Lu   +6 more
doaj   +1 more source

Cloning and expression of Neospora caninum rhoptry 2 and its potential as an immunobiological for neosporosis control

open access: yesPesquisa Veterinária Brasileira, 2021
: The protozoan Neospora caninum is known worldwide as one of the main causes of abortion in cattle. During infection, rhoptry proteins present in the apical complex of the parasite play important roles in adhesion and parasitophorous vacuole formation ...
Alceu G. dos Santos Junior   +5 more
doaj   +1 more source

Molecular Genetics of Hepatozoon canis With a Note on Effect of Parasite on the Complete Blood Count Profile of Canine Hosts

open access: yesEcology and Evolution, Volume 16, Issue 8, August 2026.
A total of 654 blood samples were collected from healthy dogs in Punjab and Khyber Pakhtunkhwa provinces in Pakistan and screened for the presence of Hepatozoon canis. Genetic diversity of the detected H. canis DNA, infection‐associated risk factors, and changes in the complete blood count of the host due to parasitic activity were also evaluated.
Madiha Rasool   +14 more
wiley   +1 more source

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