Results 71 to 80 of about 16,784 (210)

Evaluation of the cervicovaginal environment in asymptomatic Human T-cell lymphotropic virus type 1 infected women

Brazilian Journal of Infectious Diseases, 2019
Introduction: Human T-cell lymphotropic virus type 1 (HTLV-1) is sexually transmitted and causes persistent infection. This virus induces activation of the immune system and production of inflammatory cytokines.
Alisson de Aquino Firmino, Adenilda Lima Lopes Martins, Luana Leandro Gois, Taiane Silva Paixão, Everton da Silva Batista, Bernardo Galvão-Castro, Maria Fernanda Rios Grassi   +6 more
doaj   +3 more sources

Effects of bovine leukemia virus seropositivity and proviral load on milk, fat, and protein production of dairy cows

Journal of Dairy Science
: The objective was to evaluate the effects of bovine leukemia virus (BLV) infection, as determined by BLV seropositivity and proviral load, on 305-d milk, fat, and protein production of dairy cows.
Sulav Shrestha, Karin Orsel, Herman W. Barkema, Larissa Martins, Samita Shrestha, Frank van der Meer   +5 more
doaj   +1 more source

Human T-lymphotropic virus and transfusion safety. Does one size fit all? [PDF]

, 2015
Human T-cell leukemia viruses (HTLV-1 and HTLV-2) are associated with a variety of human diseases, including some severe ones. Transfusion transmission of HTLV through cellular blood components is undeniable.
Catalano, Liviana, Facco, Giuseppina, Grazzini, Giuliano, Liumbruno, Giancarlo Maria, Marano, Giuseppe, Piccinini, Vanessa, Pupella, Simonetta, VAGLIO, Stefania   +7 more
core   +1 more source

Antagonistic Ubiquitin Switching by USP7 and RNF40 Orchestrates KDM6A Homeostasis to License Coronavirus Susceptibility

Advanced Science, EarlyView.
We identify an antagonistic ubiquitin circuit that controls cellular permissiveness to multiple coronaviruses. The deubiquitinase USP7 stabilizes the epigenetic regulator KDM6A to upregulate viral receptors, while the E3 ligase RNF40 degrades KDM6A by catalyzing K6/K11‐ubiquitin chains of KDM6A for autophagic degradation.
Meng‐Zhuo Huang, Zhong‐Yuan Yang, Shi Wang, Yan Ge, Lan Lin, Mia Madel Alfajaro, Renata B. Filler, Wan‐Yao Song, Ming‐Zhu Kong, Jin Wei   +9 more
wiley   +1 more source

Microglial reactivity and nodule formation are associated with Synaptodendritic damage in the brains of people with HIV‐1

Brain Pathology, EarlyView.
Despite effective ART, neurocognitive impairment persists in people with HIV. Brains from PWH present exacerbated microgliosis and formation of microglial nodules that are actively engaged in neuronal phagocytosis, resulting in neuronal injury and dendritic loss.
Roberta S. Dos Reis, Lauren A. Ignatz, Sathish Selvam, Marc C. E. Wagner, Sara Gianella, Antoine Chaillon, Vanessa Gomez‐Moreno, Jeremy Martison, Leah H. Rubin, Sabina Heberlen, Valentina Stosor, Jordan Lake, Velpandi Ayyavoo   +12 more
wiley   +1 more source

A viral clonality evenness score to predict progression to adult T-cell leukaemia in asymptomatic carriers of human T-lymphotropic virus type 1 in Japan: a retrospective longitudinal cohort study

The Lancet Microbe
Summary: Background: Adult T-cell leukaemia/lymphoma (ATL) is a highly aggressive T-cell malignancy that occurs in approximately 2–7% of individuals with human T-lymphotropic virus type 1 (HTLV-1), after decades of asymptomatic infection. To address the
Snehal Dilip Karpe, PhD, Maria Artesi, PhD, Jérôme Wayet, MSc, Keith Durkin, PhD, Vincent Hahaut, PhD, ProfMD Kaoru Uchimaru, PhD, Junya Makiyama, MD, ProfMD Masako Iwanaga, MD, Atae Utsunomiya, MD, P Martijn Kolijn, PhD, ProfPhD Anton W Langerak, PhD, ProfPhD Arsène Burny, PhD, Ambroise Marçais, MD, ProfMD Olivier Hermine, MD, ProfMD Toshiki Watanabe, MD, ProfPhD Michel Georges, MD, Anne Van den Broeke, PhD   +16 more
doaj   +1 more source

Effectiveness and safety of two‐drug regimens containing an integrase inhibitor and reverse transcriptase inhibitor in a cohort of virologically suppressed people with HIV: Data from the COMBINE‐2 study

HIV Medicine, EarlyView.
Abstract Objectives This study assessed real‐world effectiveness and safety of switching to dual therapy regimens consisting of an integrase inhibitor (INSTI), and reverse transcriptase inhibitor (RTI), among suppressed people living with HIV in Europe.
Cristina Mussini, Cassidy Henegar, Lambert Assoumou, Stephane de Wit, Margaret Johnson, Eugenia Quiros‐Roldan, Chris Kenyon, Colin Deschanvres, David Zucman, Frank Post, Roya Movahedi, Laura Comi, Julie Fox, Geoffrey Liegeon, Charlotte Martin, Jonathan Edwards, Giorgio Tiecco, Marc Delforge, Leigh Ragone, Bryn Jones, Jean van Wyk, Michael Aboud, Carl Fletcher, Anton Pozniak, Vani Vannappagari   +24 more
wiley   +1 more source

Detection of HTLV-1 proviral DNA in cell-free DNA: Potential for non-invasive monitoring of Adult T cell leukaemia/lymphoma using liquid biopsy?

Frontiers in Immunology, 2023
IntroductionFragmented genomic DNA is constitutively released from dying cells into interstitial fluid in healthy tissue. In cancer, this so-called ‘cell-free’ DNA (cfDNA) released from dying malignant cells encodes cancer-associated mutations.
Thomas Joris, Thomas Joris, Jana Haddow, Graham P. Taylor, Graham P. Taylor, Lucy B. M. Cook, Lucy B. M. Cook, Lucy B. M. Cook, Lucy B. M. Cook, Aileen G. Rowan   +9 more
doaj   +1 more source

HIV-Infected Subjects With Poor CD4 T-Cell Recovery Despite Effective Therapy Express High Levels of OX40 and α4β7 on CD4 T-Cells Prior Therapy Initiation [PDF]

, 2018
Background HIV-infected subjects with suboptimal CD4 restoration despite suppressive combined antiretroviral treatment (cART) (immunodiscordant subjects) have been classically characterized after a variable period of time under cART.
Genebat González, Miguel, Herrero Fernández, Inés, Leal Noval, Manuel, Muñoz-Fernández, Mª Angeles, Olalla, Julián, Pacheco López, Yolanda María, Podzamczer, Daniel, Riera, Melchor, Romero, Jorge Del, Rosado Sánchez, Isaac, Vidal, Francesc   +10 more
core   +1 more source

Low Plasma Human Immunodeficiency Virus Type 2 Viral Load Is Independent of Proviral Load: Low Virus Production In Vivo [PDF]

Journal of Virology, 2000
ABSTRACTLevels of virus in the plasma are closely related to the pathogenicity of human immunodeficiency virus type 1 (HIV-1). HIV-2 is much less pathogenic than HIV-1, and infection with HIV-2 leads to significantly lower plasma viral load. To identify the source of this difference, we measured both viral RNA and proviral DNA in matched samples from ...
S J, Popper, A D, Sarr, A, Guèye-Ndiaye, S, Mboup, M E, Essex, P J, Kanki   +5 more
openaire   +2 more sources