Results 21 to 30 of about 6,958 (184)
Cellular prion protein and NMDA receptor modulation: protecting against excitotoxicity
Frontiers in Cell and Developmental Biology, 2014 Although it is well established that misfolding of the cellular prion protein (PrPC) into the beta-sheet-rich, aggregated scrapie conformation (PrPSc) causes a variety of transmissible spongiform encephalopathies (TSEs), the physiological roles of PrPC ...
Stefanie A.G. Black +7 more
doaj +1 more source
Role of the prion protein in copper turnover in astrocytes
Neurobiology of Disease, 2004 The prion protein (PrPc) is a glycoprotein that is not only expressed predominantly by neurones but also by other cells, including astrocytes. The recent identification of PrPc as a Cu-binding protein has opened the way to investigating its function in a
David R Brown
doaj +1 more source
Frontiers in Cellular Neuroscience, 2019 The pathological features of Alzheimer’s disease (AD) include senile plaques induced by amyloid-β (Aβ) protein deposits, neurofibrillary tangles formed by aggregates of hyperphosphorylated tau proteins and neuronal cell loss in specific position within ...
Yuan Zhang +5 more
doaj +1 more source
Transcriptomic Determinants of Scrapie Prion Propagation in Cultured Ovine Microglia. [PDF]
PLoS ONE, 2016 Susceptibility to infection by prions is highly dependent on the amino acid sequence and host expression of the cellular prion protein (PrPC); however, cellular expression of a genetically susceptible PrPC is insufficient.
Juan F Muñoz-Gutiérrez +4 more
doaj +1 more source
Dopamine induces the accumulation of insoluble prion protein and affects autophagic flux
Frontiers in Cellular Neuroscience, 2015 Accumulation of protein aggregates is a histopathological hallmark of several neurodegenerative diseases, but in most cases the aggregation occurs without defined mutations or clinical histories, suggesting that certain endogenous metabolites can promote
Marcio Henrique Mello da Luz +6 more
doaj +1 more source
Prion, 2023 Prions are misfolded proteins that accumulate within the brain in association with a rare group of fatal and infectious neurological disorders in humans and animals.
Jessy A. Slota +4 more
doaj +1 more source
Cellular prion protein (PrPC) protects neuronal cells from the effect of huntingtin aggregation [PDF]
Journal of Cell Science, 2007 The effect of normal cellular prion protein (PrPC) on abnormal protein aggregation was examined by transfecting huntingtin fragments (Htt) into SN56 neuronal-derived cells depleted of PrPC by RNA interference. PrPC depletion caused an increase in both the number of cells containing granules and the number of apoptotic cells.
Kyung-Jin, Lee +4 more
openaire +2 more sources
The Functional Role of Prion Protein (PrPC) on Autophagy [PDF]
Pathogens, 2013 Cellular prion protein (PrPC) plays an important role in the cellular defense against oxidative stress. However, the exact protective mechanism of PrPC is unclear. Autophagy is essential for survival, differentiation, development, and homeostasis in several organisms.
Hae-Young Shin, Yong-Sun Kim, Jae-Min Oh
openaire +3 more sources
Glycosylphosphatidylinositols: More than just an anchor?
Communicative & Integrative Biology, 2016 There is increasing interest in the role of glycosylphosphatidylinositol (GPI) anchors that attach some proteins to cell membranes. Far from being biologically inert, GPIs influence the targeting, intracellular trafficking and function of the attached ...
Clive Bate, William Nolan, Alun Williams
doaj +1 more source
Stem Cell Research & Therapy, 2017 Background Glioblastoma (GBM), a highly aggressive brain tumor, contains a subpopulation of glioblastoma stem-like cells (GSCs) that play roles in tumor maintenance, invasion, and therapeutic resistance.
Rebeca Piatniczka Iglesia +5 more
doaj +1 more source