Results 31 to 40 of about 6,958 (184)

The cellular prion protein interacts with and promotes the activity of Na,K-ATPases.

PLoS ONE, 2021
The prion protein (PrP) is best known for its ability to cause fatal neurodegenerative diseases in humans and animals. Here, we revisited its molecular environment in the brain using a well-developed affinity-capture mass spectrometry workflow that ...
Declan Williams, Mohadeseh Mehrabian, Hamza Arshad, Shehab Eid, Christopher Sackmann, Wenda Zhao, Xinzhu Wang, Farinaz Ghodrati, Claire E Verkuyl, Joel C Watts, Gerold Schmitt-Ulms   +10 more
doaj   +1 more source

Prion therapeutics: Lessons from the past

Prion, 2022
Prion diseases are a group of incurable zoonotic neurodegenerative diseases (NDDs) in humans and other animals caused by the prion proteins. The abnormal folding and aggregation of the soluble cellular prion proteins (PrPC) into scrapie isoform (PrPSc ...
Kyu Hwan Shim, Niti Sharma, Seong Soo A An   +2 more
doaj   +1 more source

New insights into cellular prion protein (PrPc) functions: The “ying and yang” of a relevant protein [PDF]

Brain Research Reviews, 2009
The conversion of cellular prion protein (PrP(c)), a GPI-anchored protein, into a protease-K-resistant and infective form (generally termed PrP(sc)) is mainly responsible for Transmissible Spongiform Encephalopathies (TSEs), characterized by neuronal degeneration and progressive loss of basic brain functions.
Nicolás i Pallejà, Josep Oriol, Gavín Marín, Rosalina, Río Fernández, José Antonio del   +2 more
openaire   +4 more sources

Post-translational modifications in prion diseases

Frontiers in Molecular Neuroscience
More than 650 reversible and irreversible post-translational modifications (PTMs) of proteins have been listed so far. Canonical PTMs of proteins consist of the covalent addition of functional or chemical groups on target backbone amino-acids or the ...
Chloé Bizingre, Chloé Bizingre, Clara Bianchi, Clara Bianchi, Anne Baudry, Anne Baudry, Aurélie Alleaume-Butaux, Aurélie Alleaume-Butaux, Benoit Schneider, Benoit Schneider, Benoit Schneider, Mathéa Pietri, Mathéa Pietri   +12 more
doaj   +1 more source

Synaptic Dysfunction in Prion Diseases: A Trafficking Problem?

International Journal of Cell Biology, 2013
Synaptic dysfunction is an important cause of neurological symptoms in prion diseases, a class of clinically heterogeneous neurodegenerative disorders caused by misfolding of the cellular prion protein (PrPC).
Assunta Senatore, Elena Restelli, Roberto Chiesa   +2 more
doaj   +1 more source

An antipsychotic drug exerts anti-prion effects by altering the localization of the cellular prion protein.

PLoS ONE, 2017
Prion diseases are neurodegenerative conditions characterized by the conformational conversion of the cellular prion protein (PrPC), an endogenous membrane glycoprotein of uncertain function, into PrPSc, a pathological isoform that replicates by imposing
Claudia Stincardini, Tania Massignan, Silvia Biggi, Saioa R Elezgarai, Valeria Sangiovanni, Ilaria Vanni, Michael Pancher, Valentina Adami, Jorge Moreno, Matteo Stravalaci, Giulia Maietta, Marco Gobbi, Alessandro Negro, Jesús R Requena, Joaquín Castilla, Romolo Nonno, Emiliano Biasini   +16 more
doaj   +1 more source

Prominent Stress Response of Purkinje Cells in Creutzfeldt–Jakob Disease

Neurobiology of Disease, 2001
To examine the role of stress-related 70-kDa heat shock proteins (Hsp-s) in Creutzfeldt–Jakob disease (CJD), we performed immunocytochemistry to detect Hsp-72 and Hsp-73, together with the abnormal (PrPSc) and the presumed cellular form (PrPC) of the ...
Gábor G. Kovács, István Kurucz, Herbert Budka, Csaba Ádori, Ferenc Müller, Péter Ács, Stefan Klöppel, Hermann M. Schätzl, R.John Mayer, Lajos László   +9 more
doaj   +1 more source

Enhanced Sensitivity of a Modified Quaking‐Induced Conversion Diagnostic Test for the Broad Detection of Sporadic and Inherited Prion Diseases: A Retrospective Study

Annals of Neurology, EarlyView.
Objective Quaking‐induced conversion (QuIC) tests, which detect prion‐seeding activity in cerebrospinal fluid (CSF), have markedly advanced the antemortem diagnosis of prion diseases such as Creutzfeldt‐Jakob disease (CJD). These tests provide high diagnostic accuracy and enable timely differentiation from other rapidly progressive neurodegenerative ...
Jennifer Myskiw, Rebecca Fox, Dominic M.S. Kielich, Lise Lamoureux, Melanie Leonhardt, Olivia Nykvist, Jessy A. Slota, Kristen Avery, Clark Phillipson, Kathy Frost, Sharon Simon, Brian S. Appleby, Ben A. Bailey‐Elkin, Stephanie A. Booth   +13 more
wiley   +1 more source

Common themes in PrP signaling: the Src remains the same

Frontiers in Cell and Developmental Biology, 2014
The ability of the cellular prion protein (PrPC) to trigger intracellular signals appears central to neurodegeneration pathways, yet the physiological significance of such signals is rather puzzling.
Katharina eOchs, Edward eMálaga-Trillo, Edward eMálaga-Trillo   +2 more
doaj   +1 more source

Alterations in the brain interactome of the intrinsically disordered N-terminal domain of the cellular prion protein (PrPC) in Alzheimer's disease. [PDF]

PLoS ONE, 2018
The cellular prion protein (PrPC) is implicated in neuroprotective signaling and neurotoxic pathways in both prion diseases and Alzheimer's disease (AD). Specifically, the intrinsically disordered N-terminal domain (N-PrP) has been shown to interact with
Sarah Ulbrich, Petra Janning, Ralf Seidel, Jakob Matschke, Anika Gonsberg, Sebastian Jung, Markus Glatzel, Martin Engelhard, Konstanze F Winklhofer, Jörg Tatzelt   +9 more
doaj   +1 more source