Results 71 to 80 of about 6,958 (184)

Iron-Restricted Diet Affects Brain Ferritin Levels, Dopamine Metabolism and Cellular Prion Protein in a Region-Specific Manner

Frontiers in Molecular Neuroscience, 2017
Iron is an essential micronutrient for several physiological functions, including the regulation of dopaminergic neurotransmission. On the other hand, both iron, and dopamine can affect the folding and aggregation of proteins related with ...
Jessica M. V. Pino, Marcio H. M. da Luz, Hanna K. M. Antunes, Hanna K. M. Antunes, Sara Q. de Campos Giampá, Vilma R. Martins, Kil S. Lee   +6 more
doaj   +1 more source

The Risk of Transmission of Genetic Prion Diseases is Greater Than 50%

European Journal of Neurology, Volume 32, Issue 12, December 2025.
This study investigated whether transmission ratio distortion (TRD) occurs in inherited prion diseases, specifically familial Creutzfeldt‐Jakob disease (p.E200K variant) and fatal familial insomnia (p.D178N variant), despite the theoretical 50% autosomal dominant inheritance risk.
Izaro Kortazar‐Zubizarreta, Africa Manero‐Azua, Hasier Eraña, Urko Aguire, Joaquín Castilla, Guiomar Perez de Nanclares   +5 more
wiley   +1 more source

A Prion‐Like Domain in EBV EBNA1 Promotes Phase Separation and Enables SRRM1 Splicing

Advanced Science, Volume 12, Issue 41, November 6, 2025.
This study discoveries that EBV EBNA1 behaves as a prion‐like protein, verified using cell‐based assays and the Saccharomyces cerevisiae Sup35p prion identification system. The prion‐like domain of EBNA1 drives liquid–liquid phase separation. EBNA1 interacts with the splicing factor SRSF1 to regulate the expression of the SRRM1 splicing isoforms ...
Xiaoyue Zhang, Zhengshuo Li, Run Zheng, Xiang Zheng, Jia Wang, Can Liu, Yangge Wu, Yuqing Wen, Chunlin Ou, Songqing Fan, Chenxiao Xu, Junrui Tian, Qun Yan, Hao Nan, Xiaodong Xu, Hui Wang, Qiu Peng, Jian Ma   +17 more
wiley   +1 more source

RPS27L Enhances Myogenesis and Muscle Mass by Targeting IGF1 Through Liquid‐Liquid Phase Separation

Advanced Science, Volume 12, Issue 44, November 27, 2025.
Muscle‐specific RPS27L knock‐in mice exhibit increased body weight, muscle mass, and enhanced muscle regenerative capacity. RPS27L drives myogenesis by promoting myoblast proliferation, while inhibiting myogenic differentiation. Mechanistically, RPS27L targets IGF1 protein by liquid‐liquid phase separation through its N‐terminal intrinsically ...
Xiaoqin Liu, Yilong Yao, Junyu Yan, Mu Zeng, Xinhao Fan, Yijie Tang, Jiju Li, Yanwen Liu, Shanying Yan, Wei Wang, Lijuan Chen, Ruipu Chen, Yuxin Huang, Honor Calnan, Heng Wang, Graham Gardner, Yalan Yang, Zhonglin Tang   +17 more
wiley   +1 more source

Role of donor genotype in RT-QuIC seeding activity of chronic wasting disease prions using human and bank vole substrates.

PLoS ONE, 2020
Chronic wasting disease is a transmissible spongiform encephalopathy of cervids. This fatal neurodegenerative disease is caused by misfolding of the cellular prion protein (PrPC) to pathogenic conformers (PrPSc), and the pathogenic forms accumulate in ...
Soyoun Hwang, Justin J Greenlee, Eric M Nicholson   +2 more
doaj   +1 more source

Amyloid beta binding partners in the brain tissue of older adults

Alzheimer's &Dementia, Volume 21, Issue 11, November 2025.
Abstract INTRODUCTION The mechanism linking extracellular amyloid beta (Aβ) with intraneuronal tau tangles, pathological hallmarks of Alzheimer's disease (AD), is not understood; it was tested in the current study through Aβ binding partners. METHODS Data were from decedents of community‐based clinical‐pathological studies.
Shahram Oveisgharan, Lei Yu, Yanling Wang, Jingyun Yang, Ricardo Vialle, Katia de Paiva Lopes, Shinya Tasaki, Tracey L. Young‐Pearse, Philip L De Jager, Vladislav A. Petyuk, Julie A. Schneider, Nicholas T. Seyfried, David A. Bennett   +12 more
wiley   +1 more source

A New Strategy for Treating Renal Fibrosis Based on a Drug‐Food Homogeneous Formula of Traditional Chinese Medicine

Food Science &Nutrition, Volume 13, Issue 11, November 2025.
Renal fibrosis is a common pathological feature of chronic kidney disease as it progresses to the end stage. This study explores a novel medicinal‐edible homologous formulation delivered via colon to target the gut–kidney axis. The formulation repaired the intestinal barrier, reduced systemic LPS and inflammation, and subsequently suppressed renal ...
Gao Zitian, Tang Yuyan, Huang Luyan, Xu Jiahui, Huang Lusheng, Sun Weiqian, He Haidong, Chen Yu   +7 more
wiley   +1 more source

De Novo Generation of a Unique Cervid Prion Strain Using Protein Misfolding Cyclic Amplification

mSphere, 2017
Substantial evidence supports the hypothesis that prions are misfolded, infectious, insoluble, and protease-resistant proteins (PrPRES) devoid of instructional nucleic acid that cause transmissible spongiform encephalopathies (TSEs).
Crystal Meyerett-Reid, A. Christy Wyckoff, Terry Spraker, Bruce Pulford, Heather Bender, Mark D. Zabel   +5 more
doaj   +1 more source

PrPC has nucleic acid chaperoning properties similar to the nucleocapsid protein of HIV-1

Comptes Rendus. Biologies, 2002
The function of the cellular prion protein (PrP C ) remains obscure. Studies suggest that PrP C functions in several processes including signal transduction and Cu 2+ metabolism. PrP C
Derrington, Edmund, Gabus, Caroline, Leblanc, Pascal, Chnaidermann, Jonas, Grave, Linda, Dormont, Dominique, Swietnicki, Wieslaw, Morillas, Manuel, Marck, Daniel, Nandi, Pradip, Darlix, Jean-Luc   +10 more
openaire   +3 more sources

Soluble polymorphic bank vole prion proteins induced by co-expression of quiescin sulfhydryl oxidase in E. coli and their aggregation behaviors

Microbial Cell Factories, 2017
Background The infectious prion protein (PrPSc or prion) is derived from its cellular form (PrPC) through a conformational transition in animal and human prion diseases.
Romany Abskharon, Johnny Dang, Ameer Elfarash, Zerui Wang, Pingping Shen, Lewis S. Zou, Sedky Hassan, Fei Wang, Hisashi Fujioka, Jan Steyaert, Mentor Mulaj, Witold K. Surewicz, Joaquín Castilla, Alexandre Wohlkonig, Wen-Quan Zou   +14 more
doaj   +1 more source