Results 81 to 90 of about 6,958 (184)
Frontiers in Neuroscience, 2013 Mexico City Metropolitan Area children chronically exposed to high concentrations of air pollutants exhibit an early brain imbalance in genes involved in oxidative stress, inflammation, innate and adaptive immune responses along with accumulation of ...
Lilian eCalderon-Garciduenas +10 more
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Distribution of the cellular prion protein (PrPC) in brains of livestock and domesticated species
Acta Neuropathologica, 2006 In transmissible spongiform encephalopathies (TSEs) the prion protein (PrP) plays a central role in pathogenesis. The PrP gene (Prnp) has been described in a number of mammalian and avian species and its expression product, the cellular prion protein (PrP(C)), has been mapped in brains of different laboratory animals (rodent and non-human primates ...
Díaz-San Segundo, F +5 more
openaire +4 more sources
Cross-seeding of prions by aggregated α-synuclein leads to transmissible spongiform encephalopathy.
PLoS Pathogens, 2017 Aggregation of misfolded proteins or peptides is a common feature of neurodegenerative diseases including Alzheimer's, Parkinson's, Huntington's, prion and other diseases.
Elizaveta Katorcha +6 more
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Frontiers in Pharmacology, 2018 Naïve depression patients show alterations in serotonin transporter (SERT) and serotonin 2A (5HT2A) receptor clustering in peripheral lymphocytes, and these alterations have been proposed as a biomarker of therapeutic efficacy in major depression ...
Raquel Romay-Tallon +7 more
doaj +1 more source
Oncotarget, 2015 Hypoxia decreases cytotoxic responses to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) protein. Cellular prion protein (PrPc) is regulated by HIF-1α in neurons. We hypothesized that PrPc is involved in hypoxia-mediated resistance to TRAIL-induced apoptosis.
Jin-Young, Park +6 more
openaire +3 more sources
Frontiers in Cellular Neuroscience, 2019 Histopathological studies revealed that progressive neuropathies including Alzheimer, and Prion diseases among others, include accumulations of misfolded proteins intracellularly, extracellularly, or both.
Emiliano Zamponi, Gustavo F. Pigino
doaj +1 more source
Deletion of Cellular Prion Protein (PrPC) Results in Peripheral Lymphocytosis and Larger Platelets
Blood, 2015 Abstract Cellular prion protein (PrPC) is a GPI-anchored cell surface glycoprotein that is expressed in the brain, blood, bone marrow (BM), and lymphoid tissue. PrPC can be converted post-translationally into scrapie-PrP (PrPSc), which is involved in the pathogenesis of neurodegenerative diseases including Creutzfeldt-Jakob disease, Kuru
Yan Zheng +6 more
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The Hsp70/Hsp90 Chaperone Machinery in Neurodegenerative Diseases
Frontiers in Neuroscience, 2017 The accumulation of misfolded proteins in the human brain is one of the critical features of many neurodegenerative diseases, including Alzheimer's disease (AD). Assembles of beta-amyloid (Aβ) peptide—either soluble (oligomers) or insoluble (plaques) and
Rachel E. Lackie +15 more
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Neuroscience Letters, 2004 The pathological isoform of the prion protein (PrP(Sc)) has been identified to mediate transmissible spongiform encephalopathies like Creutzfeldt-Jakob disease (CJD). In contrast, the physiological function of the normal cellular prion protein (PrP(c)) is not yet understood.
Weise, J. +5 more
openaire +3 more sources